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All Studies   Meta Analysis    Recent:   

Pre exposure Hydroxychloroquine use is associated with reduced COVID19 risk in healthcare workers

Bhattacharya et al., medRxix, doi:10.1101/2020.06.09.20116806
Jun 2020  
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Case 81% Improvement Relative Risk HCQ for COVID-19  Bhattacharya et al.  Prophylaxis Is pre-exposure prophylaxis with HCQ beneficial for COVID-19? Retrospective 106 patients in India Fewer cases with HCQ (p=0.001) c19hcq.org Bhattacharya et al., medRxix, June 2020 FavorsHCQ Favorscontrol 0 0.5 1 1.5 2+
HCQ for COVID-19
1st treatment shown to reduce risk in March 2020
 
*, now with p < 0.00000000001 from 411 studies, recognized in 46 countries.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,300+ studies for 75 treatments. c19hcq.org
HCQ reduced cases from 38% to 7%. 106 people. No serious adverse effects.
risk of case, 80.7% lower, RR 0.19, p = 0.001, treatment 4 of 54 (7.4%), control 20 of 52 (38.5%), NNT 3.2.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Bhattacharya et al., 9 Jun 2020, retrospective, India, preprint, 7 authors.
This PaperHCQAll
The beneficial role of N-acetylcysteine as an adjunctive drug in treatment of COVID-19 patients in a tertiary care hospital in India: an observational study
Raja Bhattacharya, Maitry Mondal, Subhendu Bikash Naiya, Lamsaka Lyngdoh, Dr Rishav Mukherjee, Prabhat K Singh
International Journal of Research in Medical Sciences, doi:10.18203/2320-6012.ijrms20204010
Background: N-acetyl cysteine, a mucolytic agent, demonstrates free radical scavenging and anti-inflammatory properties, and prevents endothelial dysfunction by inhibition of NF-KB and formation of no adducts. This has a potential role to tackle cytokine storms, endothelial dysfunction and prothrombotic state observed in COVID-19 manifestations like ARDS and Multi organ dysfunction. Methods: Institution based descriptive cross sectional study, 164 patients from laboratory confirmed RT PCR positive COVID-19 patients, in the study period from 27 th May 2020 to 10 th August 2020, were assessed, in medical college Kolkata, a dedicated COVID-19 care facility. Results: It was observed that moderate-severe patients who received N-acetyl cysteine along with standard therapy had average hospital stay duration of 12 days, higher rate of discharge, average duration of oxygen therapy of 8 days, less number of deaths and reduced transfer to critical care facilities. Conclusions: N-acetyl cysteine can be considered as an adjunctive therapy with standard protocol driven care, due to its beneficial anti-inflammatory and free radical scavenging properties.
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HCWs who had voluntarily taken hydroxychloroquine (HCQ) prior to exposure were ' 'considered one cohort while those who had not were considered to be another. All participants ' 'with a verifiable contact history were tested for COVID-19 by rtPCR. The two cohorts were ' 'comparable in terms of age, gender, comorbidities and exposure. The primary outcome was ' 'incidence rates of rtPCR positive COVID-19 infection amongst HCQ users and non ' 'users.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>106 healthcare ' 'workers were examined in this cohort study of whom 54 were HCQ users and rest were not. The ' 'comparative analysis of incidence of infection between the two groups demonstrated that ' 'voluntary HCQ usage was associated with lesser likelihood of developing SARS-CoV-2 infection, ' 'compared to those who were not on it, X2=14.59, p&lt;0.001. None of the HCQ users noted any ' 'serious adverse ' 'effects.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>This study ' 'demonstrated that voluntary HCQ consumption as pre-exposure prophylaxis by HCWs is associated ' 'with a statistically significant reduction in risk of SARS-CoV-2. These promising findings ' 'therefore highlight the need to examine this association in greater detail among a larger ' 'sample using Randomised Controlled Trials (RCT).</jats:p></jats:sec>', 'DOI': '10.1101/2020.06.09.20116806', 'type': 'posted-content', 'created': {'date-parts': [[2020, 6, 12]], 'date-time': '2020-06-12T13:49:50Z', 'timestamp': 1591969790000}, 'source': 'Crossref', 'is-referenced-by-count': 14, 'title': 'Pre exposure Hydroxychloroquine Prophylaxis for COVID-19 in healthcare workers: a retrospective ' 'cohort', 'prefix': '10.1101', 'author': [ {'given': 'Raja', 'family': 'Bhattacharya', 'sequence': 'first', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0002-5010-7565', 'authenticated-orcid': False, 'given': 'Sampurna', 'family': 'Chowdhury', 'sequence': 'additional', 'affiliation': []}, {'given': 'Rishav', 'family': 'Mukherjee', 'sequence': 'additional', 'affiliation': []}, {'given': 'Manish', 'family': 'Kulshrestha', 'sequence': 'additional', 'affiliation': []}, {'given': 'Rohini', 'family': 'Ghosh', 'sequence': 'additional', 'affiliation': []}, {'given': 'Souvik', 'family': 'Saha', 'sequence': 'additional', 'affiliation': []}, {'given': 'Anita', 'family': 'Nandi', 'sequence': 'additional', 'affiliation': []}], 'member': '246', 'reference': [ { 'key': '2021010600450779000_2020.06.09.20116806v2.1', 'unstructured': 'Worldometers.info, Dover, Delaware, U.S.A. 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