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All Studies   Meta Analysis    Recent:   
0 0.5 1 1.5 2+ Mortality -11% Improvement Relative Risk HCQ for COVID-19  Sosa-García et al.  ICU PATIENTS Is very late treatment with HCQ beneficial for COVID-19? Retrospective 56 patients in Mexico Study underpowered to detect differences c19hcq.org Sosa-García et al., Cir Cir. 2020, 569.., Jun 2020 Favors HCQ Favors control

Experience in the management of severe COVID-19 patients in an intensive care unit

Sosa-García et al., Cir Cir. 2020, 88:5, 569-575, doi:10.24875/CIRU.20000675
Jun 2020  
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HCQ for COVID-19
1st treatment shown to reduce risk in March 2020
 
*, now known with p < 0.00000000001 from 421 studies, recognized in 42 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
3,800+ studies for 60+ treatments. c19hcq.org
Small retrospective study of 56 ICU patients in Mexico showing HCQ RR 1.1, p = 1.0.
This study is excluded in the after exclusion results of meta analysis: very late stage, >50% on oxygen/ventilation at baseline; substantial unadjusted confounding by indication likely.
risk of death, 10.5% higher, RR 1.11, p = 1.00, treatment 7 of 38 (18.4%), control 3 of 18 (16.7%).
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Sosa-García et al., 29 Jun 2020, retrospective, Mexico, peer-reviewed, baseline oxygen required 100.0%, 6 authors, average treatment delay 9.0 days.
This PaperHCQAll
Experiencia en el manejo de pacientes graves con COVID-19 en una unidad de terapia intensiva
J Ojino Sosa-García, Alan O Gutiérrez-Villaseñor, Alondra García-Briones, Juan P Romero-González, Eva Juárez-Hernández, Octavio González-Chon
Cirugía y Cirujanos, doi:10.24875/ciru.20000675
Objetivo: Describir las características clínicas y el manejo de pacientes graves con COVID-19. Método: Estudio observacional, descriptivo, longitudinal y restrospectivo. Resultados: Ingresaron 56 pacientes, el 80.3% (n = 45) de sexo masculino, con un promedio de edad de 58 [46-67] años. Las principales condiciones de comorbilidad fueron obesidad, hipertensión y diabetes. El tiempo de inicio de los síntomas al ingreso fue de 9 [7-14] días, siendo los más frecuentes disnea, fiebre y tos seca. Los datos de laboratorio fueron linfopenia y elevación de deshidrogenasa láctica, fibrinógeno, dímero D, ferritina y proteína C reactiva. El 100% de los pacientes requirieron ventilación mecánica, con una mediana de tiempo de ventilación de 12 [6-17] días, y el 66% (n = 37) requirieron posición en prono. El tratamiento farmacólogico fue a base de azitromicina, hidroxicloroquina, tocilizumab y esteroides, principalmente. Las complicaciones más frecuentes fueron lesión renal aguda, enfermedad tromboembólica venosa e infarto agudo al miocardio. La tasa de mortalidad fue del 17.8% (n = 10). Conclusión: Los pacientes graves en nuestro hospital fueron en su mayoría personas de la tercera edad y con obesidad, siendo las variables de mayor puntaje SOFA y lesión renal aguda las asociadas con mayor mortalidad.
References
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Grasselli, Zangrillo, Zanella, Antonelli, Cabrini et al., Baseline characteristics and outcomes of 1591 patients infected with SARS-CoV-2 admitted to ICUs of the Lombardy Region, Italy, JAMA
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Reding-Bernal, Sánchez-Pedraza, Moreno-Macías, Sobrino-Cossio, Barrera et al., Heritability and genetic correlation between GERD symptoms severity, metabolic syndrome, and inflammation markers in families living in Mexico City, PLoS One
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Late treatment
is less effective
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