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All Studies   Meta Analysis    Recent:   
0 0.5 1 1.5 2+ Mortality 47% Improvement Relative Risk HCQ for COVID-19  Signes-Costa et al.  LATE TREATMENT Is late treatment with HCQ beneficial for COVID-19? Retrospective 5,847 patients in multiple countries Lower mortality with HCQ (p=0.00046) c19hcq.org Signes-Costa et al., Archivos de Bronc.., Dec 2020 Favors HCQ Favors control

Prevalence and 30-day mortality in hospitalized patients with COVID-19 and prior lung diseases

Signes-Costa et al., Archivos de Bronconeumología, doi:10.1016/j.arbres.2020.11.012
Dec 2020  
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HCQ for COVID-19
1st treatment shown to reduce risk in March 2020
 
*, now known with p < 0.00000000001 from 421 studies, recognized in 42 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
3,800+ studies for 60+ treatments. c19hcq.org
47% lower mortality with HCQ/CQ. Retrospective 1,271 patients with lung disease in Canada, China, Cuba, Ecuador, Germany, Italy and Spain, 83% treated with HCQ/CQ.
Multivariable Cox regression HCQ/CQ mortality hazard ratio HR 0.53, p < 0.001.
risk of death, 47.0% lower, RR 0.53, p < 0.001, treatment 4,854, control 993, adjusted per study.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Signes-Costa et al., 16 Dec 2020, retrospective, multiple countries, peer-reviewed, 28 authors.
This PaperHCQAll
Prevalence and 30-Day Mortality in Hospitalized Patients With Covid-19 and Prior Lung Diseases
Jaime Signes-Costa, Iván J Núñez-Gil, Joan B Soriano, Ramón Arroyo-Espliguero, Charbel Maroun Eid, Rodolfo Romero, Aitor Uribarri, Inmaculada Fernández-Rozas, Marcos García Aguado, Víctor Manuel Becerra-Muñoz, Jia Huang, Martino Pepe, Enrico Cerrato, Sergio Raposeiras, Adelina Gonzalez, Francisco Franco-Leon, Lin Wang, Emilio Alfonso, Fabrizio Ugo, Juan Fortunato García-Prieto, Gisela Feltes, Mohammad Abumayyaleh, Carolina Espejo-Paeres, Jorge Jativa, Alvaro López Masjuan, Carlos Macaya, Juan A Carbonell Asíns, Vicente Estrada
Archivos de Bronconeumología, doi:10.1016/j.arbres.2020.11.012
Introduction: Patients with pre-existing respiratory diseases in the setting of COVID-19 may have a greater risk of severe complications and even death. Methods: A retrospective, multicenter, cohort study with 5847 COVID-19 patients admitted to hospitals. Patients were separated in two groups, with/without previous lung disease. Evaluation of factors associated with survival and secondary composite end-point such as ICU admission and respiratory support, were explored. Abbreviations: ACE2, angiotensin converting enzyme II; CI, confidence interval; COPD, chronic obstructive pulmonary disease; COVID-19, 2019 novel coronavirus; CQ/HCQ, chloroquine/hydroxychloroquine; FEV1, forced expiratory volume in one second; HFNC, high flow nasal cannula; HOPE-COVID-19, Health Outcome Predictive Evaluation for COVID-19; HR, hazard ratio; ICS, inhaled corticosteroids; ICU, intensive care unit; ILD, interstitial lung disease; IQR, interquartile range; MERS, middle east respiratory syndrome; RT-PCR, real time reverse transcriptase-polymerase chain reaction; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2; STROBE, strengthening the reporting of observational studies in epidemiology; WHO, World Health Organization.
Author's contributions JS-C had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis including any adverse effects. JS-C and IJN-G were involved in the design of the study. JBS, JACA were involved in data analysis. All authors were involved in the interpretation of the data and in the writing and critical review of the manuscript. Conflicts of interest All authors declare no competing interests.
References
Alqahtani, Oyelade, Aldhahir, Alghamdi, Almehmadi et al., Prevalence severity and mortality associated with COPD and smoking in patients with COVID-19: a rapid systematic review and meta-analysis, PLOS ONE, doi:10.1001/jama.2020.4326
Arentz, Yim, Klaff, Lokhandwala, Riedo et al., Characteristics and outcomes of 21 critically ill patients with COVID-19 in Washington State, JAMA, doi:10.1001/jama.2020.4326
Benjamini, Yekutieli, The control of the false discovery rate in multiple testing under dependency, Ann Stat, doi:10.1016/j.ijantimicag.2020.105949
Bouquet, Tabor, Silver, Nair, Tovchigrechko et al., Microbial burden and viral exacerbations in a longitudinal multicenter COPD cohort, Respir Res, doi:10.1183/13993003.00688-2020
Choi, Park, Lee, Suh, Song et al., Effect of asthma and asthma medication on the prognosis of patients with COVID-19, Eur Respir J, doi:10.1183/13993003.01009-2020
Gautret, Lagier, Parola, Hoang, Meddeb et al., Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial, Int J Antimicrob Agents, doi:10.1001/jama.2020.8630
Grasselli, Greco, Zanella, Albano, Antonelli et al., Risk factors associated with mortality among patients with COVID-19 in intensive care units in Lombardy, Italy, JAMA Intern Med, doi:10.1371/journal.pone.0233147
Guan, Liang, Zhao, Liang, Chen et al., Comorbidity and its impact on 1590 patients with Covid-19 in China: a nationwide analysis, Eur Respir J, doi:10.1111/all.14238
Guan, Ni, Hu, Liang, Ou et al., Clinical characteristics of coronavirus disease 2019 in China, N Engl J Med, doi:10.1016/S0140-6736(20)30183-5
Halpin, Singh, Inhaled corticosteroids and COVID-19: a systematic review and clinical perspective, Eur Respir J, doi:10.1016/j.resinv.2019.12.005
Huang, Wang, Li, Ren, Zhao et al., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China, Lancet, doi:10.1016/S0140-6736(20)30183-5
Lamprecht, Soriano, Studnicka, Kaiser, Vanfleteren et al., Determinants of underdiagnosis of COPD in national and international surveys, Chest, doi:10.1371/journal.pone.0228544
Leung, Yang, Tam, Shaipanich, Hackett et al., ACE-2 expression in the small airway epithelia of smokers and COPD patients: implications for COVID-19, Eur Respir J, doi:10.1038/s41586-020-2012-7
Li, Moore, Vasilieva, Sui, Wong et al., Angiotensinconverting enzyme 2 is a functional receptor for the SARS coronavirus, Nature, doi:10.1001/jama.2020.6775
Lian, Hao, Cai, Zhang, Zheng, Analysis of epidemiological and clinical features in older patients with corona virus disease 2019 (COVID-19) out of Wuhan, Clin Infect Dis, doi:10.18632/aging.103000
Richardson, Hirsch, Narasimhan, Crawford, Mcginn et al., Presenting characteristics comorbidities, and outcomes among 5700 patients hospitalized with COVID-19 in the New York City Area, JAMA, doi:10.1001/jama.2020.6775
Rosenberg, Dufort, Udo, Wilberschied, Kumar et al., Association of treatment with hydroxychloroquine or azithromycin with in-hospital mortality in patients with COVID-19 in New York State, JAMA, doi:10.1056/NEJMoa2021436
Satia, Cusack, Greene, Byrne, Killian et al., Prevalence and contribution of respiratory viruses in the community to rates of emergency department visits and hospitalizations with respiratory tract infections, chronic obstructive pulmonary disease and asthma, PLOS ONE, doi:10.1186/s12931-020-01340-0
Soriano, Kendrick, Paulson, Gupta, Abrams et al., Prevalence and attributable health burden of chronic respiratory diseases, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017, Lancet Respir Med, doi:10.1001/jamainternmed.2020.0994
Uribarri, Nú Ñez-Gil, Aparisi, Becerra-Mu Ñoz, Feltes et al., Impact of renal function on admission in COVID-19 patients: an analysis of the international HOPE COVID-19 (Health Outcome Predictive Evaluation for COVID 19) Registry, J Nephrol, doi:10.1183/13993003.00547-2020
Von Elm, Altman, Egger, Pocock, Gøtzsche et al., The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies, Lancet, doi:10.1001/jamainternmed.2020.3539
Wang, Chen, Chen, Liu, Dong et al., Does asthma increase the mortality of patients with COVID-19? A systematic review and meta-analysis, Int Arch Allergy Immunol, doi:10.1183/13993003.02226-2020
Wang, He, Yu, Hu, Bao et al., Coronavirus disease 2019 in elderly patients: characteristics and prognostic factors based on 4-week follow-up, J Infect, doi:10.1016/S0140-6736(07)61602-X
Wang, Hu, Hu, Zhu, Liu et al., Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China, JAMA, doi:10.1056/NEJMoa2002032
Wang, Li, Lu, Huang, Does comorbidity increase the risk of patients with COVID-19: evidence from meta-analysis, Aging, doi:10.1007/s40620-020-00790-5
Wu, Chen, Cai, Xia, Zhou et al., Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 pneumonia in Wuhan, China, JAMA Intern Med, doi:10.1093/cid/ciaa242
Yamaya, Nishimura, Deng, Sugawara, Watanabe et al., Inhibitory effects of glycopyrronium, formoterol, and budesonide on coronavirus HCoV-229E replication and cytokine production by primary cultures of human nasal and tracheal epithelial cells, Respir Investig, doi:10.1378/chest.14-2535
Zhang, Dong, Cao, Yuan, Yang et al., Clinical characteristics of 140 patients infected with SARS-CoV-2 in, Allergy, doi:10.1001/jama.2020.1585
Zhao, Meng, Kumar, Wu, Huang et al., The impact of COPD and smoking history on the severity of COVID-19: A systemic review and metaanalysis, J Med Virol, doi:10.1159/000510953
Zhou, Yang, Wang, Hu, Zhang et al., A pneumonia outbreak associated with a new coronavirus of probable bat origin, Nature, doi:10.1038/nature02145
Late treatment
is less effective
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