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0 0.5 1 1.5 2+ Mortality 46% Improvement Relative Risk HCQ  Sánchez-Álvarez et al.  LATE TREATMENT Is late treatment with HCQ beneficial for COVID-19? Retrospective 375 patients in Spain Lower mortality with HCQ (p=0.005) Sánchez-Álvarez et al., Nefrología, Apr 2020 Favors HCQ Favors control

Status of SARS-CoV-2 infection in patients on renal replacement therapy. Report of the COVID-19 Registry of the Spanish Society of Nephrology (SEN)

Sánchez-Álvarez et al., Nefrología, doi:10.1016/j.nefroe.2020.04.002
Apr 2020  
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Analysis of 868 patients on renal replacement therapy. Statistically significant reduction in mortality with HCQ for patients on dialysis (OR 0.47, p=0.005).
No statistically significant change was found for transplant patients (the result is not given but likely the sample size is too small - the number of transplant patients was half the number of dialysis patients).
risk of death, 45.9% lower, RR 0.54, p = 0.005, treatment 322, control 53, odds ratio converted to relative risk.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Sánchez-Álvarez et al., 27 Apr 2020, retrospective, database analysis, Spain, peer-reviewed, mean age 67.0, 10 authors.
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Situación de la infección por SARS-CoV-2 en pacientes en tratamiento renal sustitutivo. Informe del Registro COVID-19 de la Sociedad Española de Nefrología (SEN)
J Emilio Sánchez-Álvarez, Miguel Pérez Fontán, Carlos Jiménez Martín, Miquel Blasco Pelícano, Carlos Jesús Cabezas Reina, Ángel M Sevillano Prieto, Edoardo Melilli, Marta Crespo Barrios, Manuel Macía Heras, María Dolores Del Pino Y Pino
Nefrología, doi:10.1016/j.nefro.2020.04.002
Introduction: The recent appearance of the SARS-CoV-2 coronavirus pandemic has had a significant impact on the general population. Patients on renal replacement therapy (RRT) have not been unaware of this situation and due to their characteristics they are especially vulnerable. We present the results of the analysis of the COVID-19 Registry of the Spanish Society of Nephrology. Material and methods: The Registry began operating on March 18th, 2020. It collects epidemiological variables, contagion and diagnosis data, signs and symptoms, treatments and outcomes. It is an online registry. Patients were diagnosed with SARS-CoV-2 infection based on the results of the PCR of the virus, carried out both in patients who had manifested compatible symptoms or had suspicious signs, as well as in those who had undergone screening after some contact acquainted with another patient.
Conflicts of interest The authors have no conflicts of interest to declare.
Chen, Liu, Liu, Xu, Xia et al., A pilot study of hydroxychloroquine in treatment of patients with common coronavirus disease-19 (COVID19), J Zhejiang Univ (Med Sci, doi:10.3785/j.issn.1008-9292.2020.03.03
Ferrey, Choi, Hanna, Chang, Tantisattamo et al., A case of novel coronavirus disease 19 in a chronic hemodialysis patient presenting with gastroenteritis and developing severe pulmonary disease, Am J Nephrol, doi:10.1159/000507417
Garg, Kim, Whitaker, 'halloran, Cummings et al., Hospitalization rates and characteristics of patients hospitalized with laboratory-confirmed coronavirus disease COVID-NET-2019, 14 States, MMWR Morb Mortal Wkly Rep, doi:10.15585/mmwr.mm6915e3
Gautret, Lagier, Parola, Hoang, Meddeb et al., Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label nonrandomized clinical trial, Int J Antimicrob Agents
Guan, Ni, Hu, Liang, Ou et al., Clinical characteristics of coronavirus disease 2019 in China, N Engl J Med, doi:10.1056/NEJMoa2002032
Henry, Lippi, Chronic kidney disease is associated with severe coronavirus disease 2019 (COVID-19) infection, Int Urol Nephrol, doi:10.1007/s11255-020-02451-9
Hoffmann, Kleine-Weber, Schroeder, Krüger, Herrler et al., SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor, Cell, doi:10.3785/j.issn.1008-9292.2020.03.03
Kuba, Imai, Rao, Gao, Guo et al., A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury, Nat Med, doi:10.1016/j.cell.2020.02.052
Liu, Huang, Xu, Yang, Qin et al., Anti-hypertensive Angiotensin II receptor blockers associated to mitigation of disease severity in elderly COVID-19 patients, medRxiv, doi:10.1101/2020.03.20.20039586
Liu, Zhao, Liu, Xu, Wong et al., T-cell immunity of SARS-CoV: implications for vaccine development against MERS-CoV, Antiviral Res
Paton, Lee, Xu, Ooi, Cheung et al., Chloroquine for influenza prevention: a randomized, double-blind, placebo controlled trial, Lancet Infect Dis
Sparks, Hiremath, South, Welling, Luther et al., The coronavirus conundrum: ACE2 and hypertension edition, doi:10.1101/2020.03.20.20039586
Vaziri, Pahl, Crum, Norris, Effect of uremia on structure and function of immune system, J Ren Nutr
Wang, Hu, Hu, Zhu, Liu et al., Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China, JAMA
Zhu, Xu, Ma, Yang, Guan et al., Successful recovery of COVID-19 pneumonia in a renal transplant recipient with long-term immunosuppression, Am J Transplant, doi:10.1111/ajt.15869
Late treatment
is less effective
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