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All Studies   Meta Analysis    Recent:   

Status of SARS-CoV-2 infection in patients on renal replacement therapy. Report of the COVID-19 Registry of the Spanish Society of Nephrology (SEN)

Sánchez-Álvarez et al., Nefrología, doi:10.1016/j.nefroe.2020.04.002
Apr 2020  
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Mortality 46% Improvement Relative Risk HCQ  Sánchez-Álvarez et al.  LATE TREATMENT Is late treatment with HCQ beneficial for COVID-19? Retrospective 375 patients in Spain Lower mortality with HCQ (p=0.005) c19hcq.org Sánchez-Álvarez et al., Nefrología, Apr 2020 FavorsHCQ Favorscontrol 0 0.5 1 1.5 2+
HCQ for COVID-19
1st treatment shown to reduce risk in March 2020
 
*, now with p < 0.00000000001 from 411 studies, recognized in 46 countries.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,300+ studies for 75 treatments. c19hcq.org
Analysis of 868 patients on renal replacement therapy. Statistically significant reduction in mortality with HCQ for patients on dialysis (OR 0.47, p=0.005).
No statistically significant change was found for transplant patients (the result is not given but likely the sample size is too small - the number of transplant patients was half the number of dialysis patients).
risk of death, 45.9% lower, RR 0.54, p = 0.005, treatment 322, control 53, odds ratio converted to relative risk.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Sánchez-Álvarez et al., 27 Apr 2020, retrospective, database analysis, Spain, peer-reviewed, mean age 67.0, 10 authors.
This PaperHCQAll
Situación de la infección por SARS-CoV-2 en pacientes en tratamiento renal sustitutivo. Informe del Registro COVID-19 de la Sociedad Española de Nefrología (SEN)
J Emilio Sánchez-Álvarez, Miguel Pérez Fontán, Carlos Jiménez Martín, Miquel Blasco Pelícano, Carlos Jesús Cabezas Reina, Ángel M Sevillano Prieto, Edoardo Melilli, Marta Crespo Barrios, Manuel Macía Heras, María Dolores Del Pino Y Pino
Nefrología, doi:10.1016/j.nefro.2020.04.002
Introduction: The recent appearance of the SARS-CoV-2 coronavirus pandemic has had a significant impact on the general population. Patients on renal replacement therapy (RRT) have not been unaware of this situation and due to their characteristics they are especially vulnerable. We present the results of the analysis of the COVID-19 Registry of the Spanish Society of Nephrology. Material and methods: The Registry began operating on March 18th, 2020. It collects epidemiological variables, contagion and diagnosis data, signs and symptoms, treatments and outcomes. It is an online registry. Patients were diagnosed with SARS-CoV-2 infection based on the results of the PCR of the virus, carried out both in patients who had manifested compatible symptoms or had suspicious signs, as well as in those who had undergone screening after some contact acquainted with another patient.
Conflicts of interest The authors have no conflicts of interest to declare.
References
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Late treatment
is less effective
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