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0 0.5 1 1.5 2+ Mortality 33% Improvement Relative Risk Ventilation -448% Death/intubation 17% c19hcq.org Salvador et al. HCQ for COVID-19 LATE TREATMENT Is late treatment with HCQ beneficial for COVID-19? Prospective study of 245 patients in Portugal Higher ventilation with HCQ (p=0.003) Salvador et al., Cureus, doi:10.7759/cureus.13687 Favors HCQ Favors control
Clinical Features and Prognostic Factors of 245 Portuguese Patients Hospitalized With COVID-19
Salvador et al., Cureus, doi:10.7759/cureus.13687
Salvador et al., Clinical Features and Prognostic Factors of 245 Portuguese Patients Hospitalized With COVID-19, Cureus, doi:10.7759/cureus.13687
Mar 2021   Source   PDF  
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Prospective study of 245 hospitalized patients, 121 treated with HCQ, showing lower (non-statistically significant) mortality and higher ventilation at 30 days. Confounding by indication is likely.
risk of death, 32.9% lower, RR 0.67, p = 0.10, treatment 28 of 121 (23.1%), control 58 of 124 (46.8%), NNT 4.2, odds ratio converted to relative risk, multivariate.
risk of mechanical ventilation, 447.8% higher, RR 5.48, p = 0.003, treatment 32 of 121 (26.4%), control 12 of 124 (9.7%), odds ratio converted to relative risk, multivariate.
risk of death/intubation, 16.7% lower, RR 0.83, p = 0.21, treatment 51 of 121 (42.1%), control 63 of 124 (50.8%), NNT 12, odds ratio converted to relative risk, univariate.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Salvador et al., 4 Mar 2021, prospective, Portugal, peer-reviewed, 10 authors.
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Abstract: Open Access Original Article DOI: 10.7759/cureus.13687 Clinical Features and Prognostic Factors of 245 Portuguese Patients Hospitalized With COVID-19 Pedro Salvador 1 , Pedro Oliveira 1 , Tiago Costa 2 , Mariana Fidalgo 2 , Raul Neto 3 , Maria Leonor Silva 2 , Cristóvão Figueiredo 4 , Vera Afreixo 5 , Tiago Gregório 2 , Luís Malheiro 4 1. Internal Medicine Department, Centro Hospitalar Vila Nova De Gaia, Vila Nova de Gaia, PRT 2. Internal Medicine Department, Centro Hospitalar Vila Nova De Gaia, Vila Nova De Gaia, PRT 3. Intensive Medicine Department, Centro Hospitalar Vila Nova de Gaia, Vila Nova de Gaia, PRT 4. Infectious Diseases Department, Centro Hospitalar Vila Nova De Gaia, Vila Nova De Gaia, PRT 5. Center for Research and Development in Mathematics and Applications, Department of Mathematics, University of Aveiro, Aveiro, PRT Corresponding author: Pedro Salvador, pedrosalvad@gmail.com Abstract
Late treatment
is less effective
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