Clinical Features and Prognostic Factors of 245 Portuguese Patients Hospitalized With COVID-19
et al., Cureus, doi:10.7759/cureus.13687
, Clinical Features and Prognostic Factors of 245 Portuguese Patients Hospitalized With COVID-19, Cureus, doi:10.7759/cureus.13687
Prospective study of 245 hospitalized patients, 121 treated with HCQ, showing lower (non-statistically significant) mortality and higher ventilation at 30 days. Confounding by indication is likely.
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risk of death, 32.9% lower, RR 0.67, p = 0.10, treatment 28 of 121 (23.1%), control 58 of 124 (46.8%), NNT 4.2, odds ratio converted to relative risk, multivariate.
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risk of mechanical ventilation, 447.8% higher, RR 5.48, p = 0.003, treatment 32 of 121 (26.4%), control 12 of 124 (9.7%), odds ratio converted to relative risk, multivariate.
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risk of death/intubation, 16.7% lower, RR 0.83, p = 0.21, treatment 51 of 121 (42.1%), control 63 of 124 (50.8%), NNT 12, odds ratio converted to relative risk, univariate.
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| Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates |
Salvador et al., 4 Mar 2021, prospective, Portugal, peer-reviewed, 10 authors.
Abstract: Open Access Original
Article
DOI: 10.7759/cureus.13687
Clinical Features and Prognostic Factors of 245
Portuguese Patients Hospitalized With COVID-19
Pedro Salvador 1 , Pedro Oliveira 1 , Tiago Costa 2 , Mariana Fidalgo 2 , Raul Neto 3 , Maria Leonor Silva 2 ,
Cristóvão Figueiredo 4 , Vera Afreixo 5 , Tiago Gregório 2 , Luís Malheiro 4
1. Internal Medicine Department, Centro Hospitalar Vila Nova De Gaia, Vila Nova de Gaia, PRT 2. Internal Medicine
Department, Centro Hospitalar Vila Nova De Gaia, Vila Nova De Gaia, PRT 3. Intensive Medicine Department, Centro
Hospitalar Vila Nova de Gaia, Vila Nova de Gaia, PRT 4. Infectious Diseases Department, Centro Hospitalar Vila Nova
De Gaia, Vila Nova De Gaia, PRT 5. Center for Research and Development in Mathematics and Applications,
Department of Mathematics, University of Aveiro, Aveiro, PRT
Corresponding author: Pedro Salvador, pedrosalvad@gmail.com
Abstract
Late treatment
is less effective
is less effective
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