Hydroxychloroquine Use on Healthcare Workers Exposed to COVID-19 - A Pandemic Hospital Experience
Polat et al.
, Hydroxychloroquine Use on Healthcare Workers Exposed to COVID-19 - A Pandemic Hospital Experience
, Medical Journal of Bakirkoy, 16:3, 280-6, doi:10.5222/BMJ.2020.50469
Small prophylaxis study of 208 healthcare workers in Turkey, 138 with high risk exposure received HCQ, while 70 with low and medium risk exposure did not. COVID-19 cases were lower in the treatment group, relative risk RR 0.43, p = 0.026. Since the control group had lower risk, the actual benefit may be larger.
risk of case, 57.0% lower, RR 0.43, p = 0.03, treatment 12 of 138 (8.7%), control 14 of 70 (20.0%), NNT 8.8.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Polat et al., 30 Sep 2020, prospective, Turkey, peer-reviewed, 3 authors.
Abstract: Original Article
Med J Bakirkoy 2020;16(3):280-6
Medical Journal of Bakirkoy
Hydroxychloroquine Use on Healthcare Workers Exposed to COVID-19
-A Pandemic Hospital Experience
COVİD -19 Temas Öyküsü Olan Sağlık Çalışanlarında Hidroksiklorokin
Kullanımı; Bir Pandemi Hastanesi Deneyimi
Ozlem Polat1 , Ramazan Korkusuz2 , Murathan Berber3
University of Health Sciences, Bakırkoy, Dr. Sadi Konuk Training and Research Hospital, Department of Family Medicine, Istanbul, Turkey
University of Health Sciences, Bakırkoy, Dr. Sadi Konuk Training and Research Hospital, Department of Infectious Diseases and Clinical
Microbiology, Istanbul, Turkey
University of Health Sciences, Bakırkoy, Dr. Sadi Konuk Training and Research Hospital, Employee Health Unit, Istanbul, Turkey
Received: 07.07.2020 / Accepted: 02.09.2020 / Published Online: 30.09.2020
Cite as: Polat O, Korkusuz R, Berber M. Hydroxychloroquine use on healthcare workers exposed to COVID-19 -A pandemic hospital experience. Med J Bakirkoy
Objective: As healthcare professionals play a role in combating the COVID-19 outbreak, the risk of disease exposure and illness increases. In
our study, we aimed to measure the effectiveness of post-contact use in order to protect the healthcare professionals who work very
intensively during the outbreak.
Method: A total of 208 healthcare workers who applied to Employee Health Unit section between the dates 25 March-25 April 2020 with a
history of contact with COVID-19 patients were included in the study. Employees were evaluated in low, moderate and high risk groups
according to the Contact Risk Algorithm included in the Evaluation of Healthcare Workers Guidelines with COVID-19 theme. Three-day
hydroxychloroquine treatment was initiated to 138 healthcare professionals who were considered as high risk. The treatment regimen was
arranged as 2x400 mg on the first day and 2x200 mg on the 2nd and 3rd days. The COVID-19 positivity rates were analyzed according to the
contact risk groups
Results: There was a statistically significant difference between occupational groups according to contact risk groups (p<0.01); the rate of
contact risk of nurses in the middle, and the doctors in the high risk groups was found to be significantly higher. When the COVID-19 positivity
rates were analyzed according to the contact risk groups, the COVID-19 positivity rates were 9.4% in the high-, 16.3% in the moderate and
14.3% in the low-risk groups. The contact was found to be related to the COVID-19 test, and the positivity rate from contact with the patient
was found to be significantly high (p<0.01).
Conclusion: Recommendations about hydroxychloroquine for postexposure prophylaxis vary. Hydroxychloroquine can be a possible effective
agent in postexposure prophylaxis. We think that conducting similar studies on larger samples can provide significant benefits to individuals
and public health.
Keywords: COVID-19, contact, healthcare workers, hydroxychloroquine
Amaç: Sağlık çalışanları COVID-19 salgını ile mücadelede rol aldıkça hastalığa maruz kalma ve hastalanma riskleri artmakta. Çalışmamızda
salgın surecinde cok yoğun şekilde çalışan sağlık çalışanlarını korumak adına temas sonrası proflaksinin etkinliğini ölçmeyi amaçladık.
Yöntem: Çalışan sağlığı birimine 25 Mart-25 Nisan 2020 tarihleri arasında COVID-19 hasta ile temas öyküsü ile başvuran 208 sağlık çalışanı
çalışmaya dahil edildi. COVID-19 temasi..
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