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0 0.5 1 1.5 2+ Mortality 13% Improvement Relative Risk HCQ for COVID-19  Orioli et al.  LATE TREATMENT Is late treatment with HCQ beneficial for COVID-19? Retrospective 73 patients in Belgium Study underpowered to detect differences Orioli et al., Diabetes & Metabolic Sy.., Dec 2020 Favors HCQ Favors control

Clinical characteristics and short-term prognosis of in-patients with diabetes and COVID-19: A retrospective study from an academic center in Belgium

Orioli et al., Diabetes & Metabolic Syndrome: Clinical Research & Reviews, doi:10.1016/j.dsx.2020.12.020
Dec 2020  
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HCQ for COVID-19
1st treatment shown to reduce risk in March 2020
*, now known with p < 0.00000000001 from 422 studies, recognized in 42 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,000+ studies for 60+ treatments.
Small retrospective study of 73 diabetic patients in Belgium, 55 HCQ patients, showing HCQ RR 0.87, p = 1.0.
risk of death, 12.7% lower, RR 0.87, p = 1.00, treatment 8 of 55 (14.5%), control 3 of 18 (16.7%), NNT 47.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Orioli et al., 14 Dec 2020, retrospective, Belgium, peer-reviewed, 9 authors.
This PaperHCQAll
Clinical characteristics and short-term prognosis of in-patients with diabetes and COVID-19: A retrospective study from an academic center in Belgium
Laura Orioli, Thomas Servais, Leïla Belkhir, Pierre-François Laterre, Jean-Paul Thissen, Bernard Vandeleene, Dominique Maiter, Jean C Yombi, Michel P Hermans
Diabetes & Metabolic Syndrome: Clinical Research & Reviews, doi:10.1016/j.dsx.2020.12.020
Background and aims: We describe the characteristics and short-term prognosis of in-patients with diabetes and COVID-19 admitted to a Belgian academic care center. Methods: We retrospectively reviewed the data on admission from patients with known or newlydiagnosed diabetes and confirmed COVID-19. First, survivors were compared to non-survivors to study the predictive factors of in-hospital death in patients with diabetes. Secondly, diabetic patients with SARS-CoV-2 pneumonia were matched for age and sex with non-diabetic patients with SARS-CoV-2 pneumonia, to study the prognosis and predictive factors of in-hospital death related to diabetes. Results: Seventy-three diabetic patients were included. Mean age was 69 (±14) years. Women accounted for 52%. Most patients had type 2 diabetes (89.0%), long-term complications of hyperglycemia (59.1%), and hypertension (80.8%). The case-fatality rate (CFR) was 15%. Non-survivors had more severe pneumonia based on imaging (p 0.029) and were less often treated with metformin (p 0.036). In patients with SARS-CoV-2 pneumonia, CFR was 15.6% in diabetic (n ¼ 64) and 25.0% in non-diabetic patients (n ¼ 128), the difference being non-significant (p 0.194). Predictive factors of in-hospital death were elevated white blood cells count (HR 9.4, CI 1.50e58.8, p 0.016) and severe pneumonia on imaging (HR 25.0, CI 1.34 e466, p 0.031) in diabetic patients, and cognitive impairment (HR 5.80, CI 1.61e20.9, p 0.007) and cardiovascular disease (HR 5.63, CI 1.54e20.6, p 0.009) in non-diabetic patients. Conclusion: In this monocentric cohort from Belgium, diabetic in-patients with COVID-19 had mostly type 2 diabetes, prevalent hyperglycemia-related vascular complications and comorbidities including hypertension. In this cohort, the CFR was not statistically different between patients with and without diabetes.
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Late treatment
is less effective
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