Retrospective 766 hospitalized patients in DRC showing mortality reduced from 29% to 11%, and improvement at 30 days increased from 65% to 84%.
Mortality cox regression adjusted hazard ratio aHR 0.26,
p < 0.001
Risk of no improvement adjusted odds ratio aOR 0.28,
p < 0.001
Using marginal structural model analysis these risks became:
Mortality MSM adjusted odds ratio aOR 0.65,
p = 0.166
Risk of no improvement MSM adjusted odds ratio aOR = 0.65,
p = 0.132
Median age 46, 630 treated with CQ+AZ.
Although the 28% lower mortality is not statistically significant, it is consistent with the significant 25% lower mortality
[20‑29%] from meta analysis of the
247 mortality results to date.
Nachega et al., 2 Oct 2020, retrospective, database analysis, DR Congo, peer-reviewed, median age 46.0, 25 authors.
