Gupta: Factors Associated With Death in Critically Ill Patients With Coronavirus Disease 2019 in the US [HCQ]

Factors Associated With Death in Critically Ill Patients With Coronavirus Disease 2019 in the US

Gupta et al., JAMA Intern. Med., doi:10.1001/jamainternmed.2020.3596

Gupta et al., Factors Associated With Death in Critically Ill Patients With Coronavirus Disease 2019 in the US, JAMA Intern. Med., doi:10.1001/jamainternmed.2020.3596

Jul 2020 Source PDF

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Analysis of 2215 intensive care unit patients showing no significant differences with this very late stage use of HCQ. HCQ+AZ mortality relative risk RR 0.96, p=0.53, HCQ and HCQ+AZ combined RR 1.06, p=0.409. This study is excluded in the after exclusion results of meta analysis: very late stage, >50% on oxygen/ventilation at baseline.

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risk of death, 6.0% higher, RR 1.06, p = 0.41, treatment 631 of 1,761 (35.8%), control 153 of 454 (33.7%).

Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates

Gupta et al., 15 Jul 2020, retrospective, USA, peer-reviewed, baseline oxygen required 87.1%, 34 authors.

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Late treatment
is less effective

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