Analgesics
Antiandrogens
Azvudine
Bromhexine
Budesonide
Colchicine
Conv. Plasma
Curcumin
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Ivermectin
Lifestyle
Melatonin
Metformin
Minerals
Molnupiravir
Monoclonals
Naso/orophar..
Nigella Sativa
Nitazoxanide
Paxlovid
Quercetin
Remdesivir
Thermotherapy
Vitamins
More

Other
Feedback
Home
Top
Results
Abstract
All HCQ studies
Meta analysis
 
Feedback
Home
next
study
previous
study
c19hcq.org COVID-19 treatment researchHCQHCQ (more..)
Melatonin Meta
Metformin Meta
Azvudine Meta
Bromhexine Meta Molnupiravir Meta
Budesonide Meta
Colchicine Meta
Conv. Plasma Meta Nigella Sativa Meta
Curcumin Meta Nitazoxanide Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   Meta Analysis    Recent:   
0 0.5 1 1.5 2+ Mortality 11% Improvement Relative Risk Mortality (b) 1% Mortality (c) -31% Mortality (d) -83% HCQ for COVID-19  Magagnoli et al.  LATE TREATMENT Is late treatment with HCQ beneficial for COVID-19? Retrospective 807 patients in the USA No significant difference in mortality c19hcq.org Magagnoli et al., Med, April 2020 Favors HCQ Favors control

Outcomes of hydroxychloroquine usage in United States veterans hospitalized with Covid-19

Magagnoli et al., Med (2020), doi:10.1016/j.medj.2020.06.001 (date from preprint)
Apr 2020  
  Post
  Facebook
Share
  Source   PDF   All   Meta
HCQ for COVID-19
1st treatment shown to reduce risk in March 2020
 
*, now known with p < 0.00000000001 from 421 studies, recognized in 42 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
3,800+ studies for 60+ treatments. c19hcq.org
Retrospective 807 hospitalized patients, no statistically significant reduction in mortality or the need for mechanical ventilation with HCQ or HCQ+AZ, or for death with HCQ+AZ, HR 1.83, p=0.009 for HCQ mortality.
The preprint notes that HCQ was more likely to be prescribed to patients with more severe disease, however this was deleted in the published version.
425 patients had dispositions of death or discharge by the end of the study period and thus did not encounter the issue of length-biased sampling and differential rates of right-censored observations among the groups.
Also see: mediterranee-infection.com
risk of death, 11.0% lower, HR 0.89, p = 0.74, treatment 39 of 148 (26.4%), control 18 of 163 (11.0%), adjusted per study, HCQ+AZ w/dispositions.
risk of death, 1.0% lower, HR 0.99, p = 0.98, treatment 30 of 114 (26.3%), control 18 of 163 (11.0%), adjusted per study, HCQ w/dispositions.
risk of death, 31.0% higher, HR 1.31, p = 0.28, treatment 49 of 214 (22.9%), control 37 of 395 (9.4%), adjusted per study, HCQ+AZ.
risk of death, 83.0% higher, HR 1.83, p = 0.009, treatment 38 of 198 (19.2%), control 37 of 395 (9.4%), adjusted per study, HCQ.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Magagnoli et al., 21 Apr 2020, retrospective, database analysis, USA, peer-reviewed, 7 authors.
This PaperHCQAll
Outcomes of Hydroxychloroquine Usage in United States Veterans Hospitalized with COVID-19
Joseph Magagnoli, Siddharth Narendran, Felipe Pereira, Tammy H Cummings, James W Hardin, S Scott Sutton, Jayakrishna Ambati
Med, doi:10.1016/j.medj.2020.06.001
In this nationwide retrospective analysis of 807 patients hospitalized with COVID-19, Magagnoli et al. report that, after adjusting for several COVID-19-relevant clinical and demographic characteristics, hydroxychloroquine use, with or without azithromycin, did not improve mortality or reduce the need for mechanical ventilation compared to no hydroxychloroquine use.
References
Azar, Shen, Romanelli, Lockhart, Smits et al., Disparities in outcomes among COVID-19 patients in a large health care system in California, Health Aff, doi:10.1377/hlthaff.2020.00598
Bessie `re, Roccia, Delinie `re, Charrie `re, Chevalier et al., Assessment of QT intervals in a case series of patients with coronavirus disease 2019 (COVID-19) infection treated with hydroxychloroquine alone or in combination with azithromycin in an intensive care unit, JAMA Cardiol, doi:10.1001/jamacardio.2020.1787
Borba, Val, Sampaio, Alexandre, Melo et al., Effect of high vs low doses of chloroquine diphosphate as adjunctive therapy for patients hospitalized with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection: a randomized clinical trial, JAMA Netw. Open
Chen, Liu, Liu, Liu, Xu et al., A pilot study of hydroxychloroquine in treatment of patients with moderate COVID-19, J. Zhejiang Univ. (Med. Sci.)
Chorin, Dai, Shulman, Wadhwani, Bar-Cohen et al., The QT interval in patients with COVID-19 treated with hydroxychloroquine and azithromycin, Nat. Med. Published online, doi:10.1038/s41591-020-0888-2
Garg, Kim, Whitaker, O'halloran, Cummings et al., Hospitalization rates and characteristics of patients hospitalized with laboratory-confirmed coronavirus disease 2019 -COVID-NET, 14 states, MMWR Morb. Mortal. Wkly. Rep
Gautret, Lagier, Parola, Hoang, Meddeb et al., Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an openlabel non-randomized clinical trial, Int. J. Antimicrob. Agents. Published, doi:10.1016/j.ijantimicag.2020.105949
Geleris, Sun, Platt, Zucker, Baldwin et al., Observational study of hydroxychloroquine in hospitalized patients with Covid-19, N. Engl. J. Med. Published, doi:10.1056/NEJMoa2012410
Grasselli, Zangrillo, Zanella, Antonelli, Cabrini et al., Baseline characteristics and outcomes of 1591 patients infected with SARS-CoV-2 admitted to ICUs of the Lombardy Region, Italy, JAMA
Guan, Ni, Hu, Liang, Ou et al., Clinical characteristics of coronavirus disease 2019 in China, N. Engl. J. Med
Hade, Lu, Bias associated with using the estimated propensity score as a regression covariate, Stat. Med
Hill, ALBERTA HOPE COVID-19 for the prevention of severe COVID19 disease
Hussain, Randomized comparison of combination azithromycin and hydroxychloroquine vs. hydroxychloroquine alone for the treatment of confirmed COVID-19
Laaksonen, Koskiahde, Juva, Dosage of antimalarial drugs for children with juvenile rheumatoid arthritis and systemic lupus erythematosus. A clinical study with determination of serum concentrations of chloroquine and hydroxychloroquine, Scand. J. Rheumatol
Liu, Cao, Xu, Wang, Zhang et al., Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro, Cell Discov
London, Kimmelman, Against pandemic research exceptionalism, Science
Lu, Efficacy and safety of hydroxychloroquine for treatment of COVID-19
Magagnoli, Narendran, Pereira, Cummings, Hardin et al., Outcomes of hydroxychloroquine usage in United States veterans hospitalized with Covid-19, doi:10.1101/2020.04.16.20065920
Mahe ´vas, Tran, Roumier, Chabrol, Paule et al., Clinical efficacy of hydroxychloroquine in patients with covid-19 pneumonia who require oxygen: observational comparative study using routine care data, BMJ
Mehra, Desai, Ruschitzka, Patel, Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19: a multinational registry analysis, Lancet. Published online, doi:10.1016/S0140-6736(20)31180-6
Mercuro, Yen, Shim, Maher, Mccoy et al., Risk of QT interval prolongation associated with use of hydroxychloroquine with or without concomitant azithromycin among hospitalized patients testing positive for coronavirus disease 2019 (COVID-19), JAMA Cardiol, doi:10.1001/jamacardio.2020.1834
Qin, Shen, Statistical methods for analyzing right-censored length-biased data under cox model, Biometrics
Ray, Liu, Shepherd, Performance of time-dependent propensity scores: a pharmacoepidemiology case study, Pharmacoepidemiol. Drug Saf
Richardson, Hirsch, Narasimhan, Crawford, Mcginn et al., Presenting characteristics, comorbidities, and outcomes among 5700 patients hospitalized with COVID-19 in the New York City area, JAMA
Rosenberg, Dufort, Udo, Wilberschied, Kumar et al., Association of treatment with hydroxychloroquine or azithromycin with inhospital mortality in patients with COVID-19 in New York state, JAMA. Published online, doi:10.1001/jama.2020.8630
Rubin, On principles for modeling propensity scores in medical research, Pharmacoepidemiol. Drug Saf
Sermo, who have used Remdesivir rate it as highly effective; 31% rate it with low effectiveness; 38% rate it as somewhere in the middle
Seto, A randomized controlled clinical trial: hydroxychloroquine for the treatment of COVID-19 in hospitalized patients (OAHU-COVID19
Stout, Pragmatic factorial trial of hydroxychloroquine, azithromycin, or both for treatment of severe SARS-CoV-2 infection
Tang, Cao, Han, Wang, Chen et al., Hydroxychloroquine in patients with mainly mild to moderate coronavirus disease 2019: open label, randomised controlled trial, BMJ
Tett, Cutler, Day, Brown, Bioavailability of hydroxychloroquine tablets in healthy volunteers, Br. J. Clin. Pharmacol
Thompson, Outcomes related to COVID-19 treated with hydroxychloroquine among in-patients with symptomatic disease (ORCHID
Tian, Baro, Zhang, Performance evaluation of regression splines for propensity score adjustment in post-market safety analysis with multiple treatments, J. Biopharm. Stat
Yang, Imbens, Cui, Faries, Kadziola, Propensity score matching and subclassification in observational studies with multi-level treatments, Biometrics
Zhou, Yu, Du, Fan, Liu et al., Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study, Lancet
Late treatment
is less effective
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Vaccines and treatments are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit