Outcomes of Hydroxychloroquine Usage in United States Veterans Hospitalized with COVID-19
Joseph Magagnoli, Siddharth Narendran, Felipe Pereira, Tammy H Cummings, James W Hardin, S Scott Sutton, Jayakrishna Ambati
Med, doi:10.1016/j.medj.2020.06.001
In this nationwide retrospective analysis of 807 patients hospitalized with COVID-19, Magagnoli et al. report that, after adjusting for several COVID-19-relevant clinical and demographic characteristics, hydroxychloroquine use, with or without azithromycin, did not improve mortality or reduce the need for mechanical ventilation compared to no hydroxychloroquine use.
References
Azar, Shen, Romanelli, Lockhart, Smits et al., Disparities in outcomes among COVID-19 patients in a large health care system in California, Health Aff,
doi:10.1377/hlthaff.2020.00598Bessie `re, Roccia, Delinie `re, Charrie `re, Chevalier et al., Assessment of QT intervals in a case series of patients with coronavirus disease 2019 (COVID-19) infection treated with hydroxychloroquine alone or in combination with azithromycin in an intensive care unit, JAMA Cardiol,
doi:10.1001/jamacardio.2020.1787Borba, Val, Sampaio, Alexandre, Melo et al., Effect of high vs low doses of chloroquine diphosphate as adjunctive therapy for patients hospitalized with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection: a randomized clinical trial, JAMA Netw. Open
Chen, Liu, Liu, Liu, Xu et al., A pilot study of hydroxychloroquine in treatment of patients with moderate COVID-19, J. Zhejiang Univ. (Med. Sci.)
Chorin, Dai, Shulman, Wadhwani, Bar-Cohen et al., The QT interval in patients with COVID-19 treated with hydroxychloroquine and azithromycin, Nat. Med. Published online,
doi:10.1038/s41591-020-0888-2Garg, Kim, Whitaker, O'halloran, Cummings et al., Hospitalization rates and characteristics of patients hospitalized with laboratory-confirmed coronavirus disease 2019 -COVID-NET, 14 states, MMWR Morb. Mortal. Wkly. Rep
Gautret, Lagier, Parola, Hoang, Meddeb et al., Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an openlabel non-randomized clinical trial, Int. J. Antimicrob. Agents. Published,
doi:10.1016/j.ijantimicag.2020.105949Geleris, Sun, Platt, Zucker, Baldwin et al., Observational study of hydroxychloroquine in hospitalized patients with Covid-19, N. Engl. J. Med. Published,
doi:10.1056/NEJMoa2012410Grasselli, Zangrillo, Zanella, Antonelli, Cabrini et al., Baseline characteristics and outcomes of 1591 patients infected with SARS-CoV-2 admitted to ICUs of the Lombardy Region, Italy, JAMA
Guan, Ni, Hu, Liang, Ou et al., Clinical characteristics of coronavirus disease 2019 in China, N. Engl. J. Med
Hade, Lu, Bias associated with using the estimated propensity score as a regression covariate, Stat. Med
Hill, ALBERTA HOPE COVID-19 for the prevention of severe COVID19 disease
Hussain, Randomized comparison of combination azithromycin and hydroxychloroquine vs. hydroxychloroquine alone for the treatment of confirmed COVID-19
Laaksonen, Koskiahde, Juva, Dosage of antimalarial drugs for children with juvenile rheumatoid arthritis and systemic lupus erythematosus. A clinical study with determination of serum concentrations of chloroquine and hydroxychloroquine, Scand. J. Rheumatol
Liu, Cao, Xu, Wang, Zhang et al., Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro, Cell Discov
London, Kimmelman, Against pandemic research exceptionalism, Science
Lu, Efficacy and safety of hydroxychloroquine for treatment of COVID-19
Magagnoli, Narendran, Pereira, Cummings, Hardin et al., Outcomes of hydroxychloroquine usage in United States veterans hospitalized with Covid-19,
doi:10.1101/2020.04.16.20065920Mahe ´vas, Tran, Roumier, Chabrol, Paule et al., Clinical efficacy of hydroxychloroquine in patients with covid-19 pneumonia who require oxygen: observational comparative study using routine care data, BMJ
Mehra, Desai, Ruschitzka, Patel, Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19: a multinational registry analysis, Lancet. Published online,
doi:10.1016/S0140-6736(20)31180-6Mercuro, Yen, Shim, Maher, Mccoy et al., Risk of QT interval prolongation associated with use of hydroxychloroquine with or without concomitant azithromycin among hospitalized patients testing positive for coronavirus disease 2019 (COVID-19), JAMA Cardiol,
doi:10.1001/jamacardio.2020.1834Qin, Shen, Statistical methods for analyzing right-censored length-biased data under cox model, Biometrics
Ray, Liu, Shepherd, Performance of time-dependent propensity scores: a pharmacoepidemiology case study, Pharmacoepidemiol. Drug Saf
Richardson, Hirsch, Narasimhan, Crawford, Mcginn et al., Presenting characteristics, comorbidities, and outcomes among 5700 patients hospitalized with COVID-19 in the New York City area, JAMA
Rosenberg, Dufort, Udo, Wilberschied, Kumar et al., Association of treatment with hydroxychloroquine or azithromycin with inhospital mortality in patients with COVID-19 in New York state, JAMA. Published online,
doi:10.1001/jama.2020.8630Rubin, On principles for modeling propensity scores in medical research, Pharmacoepidemiol. Drug Saf
Sermo, who have used Remdesivir rate it as highly effective; 31% rate it with low effectiveness; 38% rate it as somewhere in the middle
Seto, A randomized controlled clinical trial: hydroxychloroquine for the treatment of COVID-19 in hospitalized patients (OAHU-COVID19
Stout, Pragmatic factorial trial of hydroxychloroquine, azithromycin, or both for treatment of severe SARS-CoV-2 infection
Tang, Cao, Han, Wang, Chen et al., Hydroxychloroquine in patients with mainly mild to moderate coronavirus disease 2019: open label, randomised controlled trial, BMJ
Tett, Cutler, Day, Brown, Bioavailability of hydroxychloroquine tablets in healthy volunteers, Br. J. Clin. Pharmacol
Thompson, Outcomes related to COVID-19 treated with hydroxychloroquine among in-patients with symptomatic disease (ORCHID
Tian, Baro, Zhang, Performance evaluation of regression splines for propensity score adjustment in post-market safety analysis with multiple treatments, J. Biopharm. Stat
Yang, Imbens, Cui, Faries, Kadziola, Propensity score matching and subclassification in observational studies with multi-level treatments, Biometrics
Zhou, Yu, Du, Fan, Liu et al., Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study, Lancet
