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All Studies   Meta Analysis    Recent:   
0 0.5 1 1.5 2+ Mortality -134% Improvement Relative Risk HCQ for COVID-19  Kuderer et al.  LATE TREATMENT Is late treatment with HCQ beneficial for COVID-19? Retrospective 928 patients in the USA Higher mortality with HCQ (p=0.0000014) c19hcq.org Kuderer et al., Lancet, June 20, 2020, May 2020 Favors HCQ Favors control

Clinical impact of COVID-19 on patients with cancer (CCC19): a cohort study

Kuderer et al., Lancet, June 20, 2020, doi:10.1016/S0140-6736(20)31187-9 (date from preprint)
May 2020  
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HCQ for COVID-19
1st treatment shown to reduce risk in March 2020
 
*, now known with p < 0.00000000001 from 422 studies, recognized in 42 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,100+ studies for 60+ treatments. c19hcq.org
Retrospective 928 cancer patients, showing HCQ OR 1.06 [0.51-2.20]. HCQ+AZ OR 2.93 [1.79-4.79]. The relative risks of different therapies suggest that the results are overly affected by confounding by indication. Authors note: HCQ+AZ might not be the cause of increased mortality, but instead these were given to patients with more severe COVID-19.
This study is excluded in the after exclusion results of meta analysis: substantial unadjusted confounding by indication likely.
risk of death, 134.2% higher, RR 2.34, p < 0.001, treatment 45 of 181 (24.9%), control 76 of 747 (10.2%), odds ratio converted to relative risk, HCQ+AZ.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Kuderer et al., 28 May 2020, retrospective, USA, peer-reviewed, 73 authors.
This PaperHCQAll
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Late treatment
is less effective
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