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All Studies   Meta Analysis    Recent:   

COVID-19 mortality risk factors in older people in a long-term care center

Heras et al., European Geriatric Medicine, doi:10.1007/s41999-020-00432-w (date from preprint)
Sep 2020  
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Mortality 96% Improvement Relative Risk HCQ for COVID-19  Heras et al.  EARLY TREATMENT Is early treatment with HCQ + AZ beneficial for COVID-19? Retrospective 100 patients in Andorra Lower mortality with HCQ + AZ (p=0.004) c19hcq.org Heras et al., European Geriatric Medic.., Sep 2020 FavorsHCQ Favorscontrol 0 0.5 1 1.5 2+
HCQ for COVID-19
1st treatment shown to reduce risk in March 2020
 
*, now with p < 0.00000000001 from 411 studies, recognized in 46 countries.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,300+ studies for 75 treatments. c19hcq.org
Retrospective 100 COVID+ elderly nursing home patients, HCQ+AZ mortality 11.4% vs. control 61.9%, RR 0.18, p<0.001. Median age 85.
risk of death, 95.6% lower, RR 0.04, p = 0.004, treatment 8 of 70 (11.4%), control 16 of 30 (53.3%), NNT 2.4, adjusted per study.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Heras et al., 2 Sep 2020, retrospective, Andorra, peer-reviewed, median age 85.0, 13 authors, dosage not specified, this trial uses multiple treatments in the treatment arm (combined with AZ) - results of individual treatments may vary.
This PaperHCQAll
COVID-19 mortality risk factors in older people in a long-term care center
Eva Heras, Pablo Garibaldi, Maite Boix, Oliver Valero, Jorge Castillo, Yurisan Curbelo, Elso Gonzalez, Obilagilio Mendoza, Maria Anglada, Joan Carles Miralles, Petra Llull, Ricard Llovera, Josep M Piqué
European Geriatric Medicine, doi:10.1007/s41999-020-00432-w
Aim COVID-19 mortality risk factors in older people from a long term care center. Findings Male gender, low Barthel index, no pharmacological treatment and lymphocytopenia are independent mortality risk factors. Message The independent prognostic factors identified in the present study can help to adjust the healthcare resources in this population in case of new outbreaks of the COVID-19 pandemic.
Author contribution EH contributed to the study design, data collection, interpretation of the data, writing and revising the manuscript and accepts responsibility for the corresponding author. PG, MB, JC, YC, EG, OM, MA, JCM, PL, RL contributed to the data collection, data interpretation, and revising of the manuscript. OV carried out the data analysis, data interpretation, and editing of the manuscript. JMP contributed to the interpretation of the data, writing, and revising of the manuscript. All authors read and approved the final manuscript. Compliance with ethical standards Conflict of interest We declare no competing interests. Ethical approval This study was approved by the Research Ethics Committe of the Andorran Healthcare System. Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
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' 'https://doi.org/10.5582/bst.2020.01047', 'journal-title': 'Biosci Trends'}], 'container-title': 'European Geriatric Medicine', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://link.springer.com/content/pdf/10.1007/s41999-020-00432-w.pdf', 'content-type': 'application/pdf', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://link.springer.com/article/10.1007/s41999-020-00432-w/fulltext.html', 'content-type': 'text/html', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://link.springer.com/content/pdf/10.1007/s41999-020-00432-w.pdf', 'content-type': 'application/pdf', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2021, 5, 25]], 'date-time': '2021-05-25T15:54:53Z', 'timestamp': 1621958093000}, 'score': 1, 'resource': {'primary': {'URL': 'https://link.springer.com/10.1007/s41999-020-00432-w'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2020, 11, 27]]}, 'references-count': 34, 'journal-issue': {'issue': '3', 'published-print': {'date-parts': [[2021, 6]]}}, 'alternative-id': ['432'], 'URL': 'http://dx.doi.org/10.1007/s41999-020-00432-w', 'relation': { 'has-preprint': [ { 'id-type': 'doi', 'id': '10.21203/rs.3.rs-70219/v1', 'asserted-by': 'object'}, { 'id-type': 'doi', 'id': '10.21203/rs.3.rs-70219/v2', 'asserted-by': 'object'}]}, 'ISSN': ['1878-7657'], 'subject': ['General Earth and Planetary Sciences', 'General Environmental Science'], 'container-title-short': 'Eur Geriatr Med', 'published': {'date-parts': [[2020, 11, 27]]}, 'assertion': [ { 'value': '18 August 2020', 'order': 1, 'name': 'received', 'label': 'Received', 'group': {'name': 'ArticleHistory', 'label': 'Article History'}}, { 'value': '11 November 2020', 'order': 2, 'name': 'accepted', 'label': 'Accepted', 'group': {'name': 'ArticleHistory', 'label': 'Article History'}}, { 'value': '27 November 2020', 'order': 3, 'name': 'first_online', 'label': 'First Online', 'group': {'name': 'ArticleHistory', 'label': 'Article History'}}, { 'order': 1, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Compliance with ethical standards'}}, { 'value': 'We declare no competing interests.', 'order': 2, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Conflict of interest'}}, { 'value': 'This study was approved by the Research Ethics Committe of the Andorran ' 'Healthcare System.', 'order': 3, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Ethical approval'}}, { 'value': 'This content has been made available to all.', 'name': 'free', 'label': 'Free to read'}]}
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