Abstract: Journal Pre-proof Multi-institutional Analysis of 505 COVID-19 Patients Supported with ECMO: Predictors of Survival Celeste A. Hall, Jeffrey P. Jacobs, MD, Alfred H. Stammers, MSA, James D. St. Louis, MD, J.W. Awori Hayanga, MD, Michael S. Firstenberg, MD, Linda B. Mongero, CCP, Eric A. Tesdahl, PhD, Keshava Rajagopal, MD, PhD, Faisal H. Cheema, MD, Kirti Patel, CCP, Tom Coley, CCP, Anthony K. Sestokas, PhD, Marvin J. Slepian, MD, Vinay Badhwar, MD PII: S0003-4975(22)00198-9 DOI: https://doi.org/10.1016/j.athoracsur.2022.01.043 Reference: ATS 36012 To appear in: The Annals of Thoracic Surgery Received Date: 7 November 2021 Revised Date: 18 December 2021 Accepted Date: 25 January 2022 Please cite this article as: Hall CA, Jacobs JP, Stammers AH, St. Louis JD, Hayanga JWA, Firstenberg MS, Mongero LB, Tesdahl EA, Rajagopal K, Cheema FH, Patel K, Coley T, Sestokas AK, Slepian MJ, Badhwar V, Multi-institutional Analysis of 505 COVID-19 Patients Supported with ECMO: Predictors of Survival The Annals of Thoracic Surgery (2022), doi: https://doi.org/10.1016/j.athoracsur.2022.01.043. This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. © 2022 by The Society of Thoracic Surgeons Jo na ur re lP ro -p of Jacobs Page 1 of 16 Multi-institutional Analysis of 505 COVID-19 Patients Supported with ECMO: Predictors of Survival Running Head: ECMO and COVID-19 aCeleste A. Hall, a,bJeffrey P. Jacobs, MD, bAlfred H. Stammers, MSA, cJames D. St. Louis, MD, dJ.W. Awori Hayanga, MD, eMichael S Firstenberg, MD, bLinda B. Mongero, CCP, bEric A. Tesdahl, PhD, fKeshava Rajagopal, MD, PhD, f,gFaisal H. Cheema, MD, bKirti Patel, CCP, bTom Coley, CCP, of bAnthony K. Sestokas, PhD, hMarvin J. Slepian, MD, dVinay Badhwar, MD aUniversity of Florida, Gainesville, FL; bMedical Department, SpecialtyCare, Inc., Nashville, TN ; ro cChildren Hospital of Georgia, Augusta, Georgia; dWest Virginia University, Morgantown, WV; eSt -p Elizabeth Medical Center, Appleton, Wisconsin; fUniversity of Houston, Houston, TX; gHCA Research lP re Institute, Nashville, TN; hUniversity of Arizona, Tucson, AZ ur na Presented at the Sixty-eighth Annual Meeting of the Southern Thoracic Surgical Association, Atlanta, GA, Nov 3-6, 2021. Keywords: Extracorporeal Membrane Oxygenation, Coronavirus, COVID-19, Pulmonary failure, Jo acute respiratory distress syndrome Words: 4,496/4500 Corresponding Author: Jeffrey P. Jacobs, University of Florida, 1600 SW Archer Rd, Gainesville, Florida; jeffjacobs@msn.com Jacobs Page 2 of 16 Abstract Background: We reviewed our experience with 505 patients with confirmed COVID-19 supported with ECMO at 45 hospitals and estimated risk factors for mortality. Methods: A multi-institutional database was created and utilized to assess all patients with COVID-19 who were supported with ECMO. A Bayesian mixed-effects logistic regression model was estimated to assess the effect on survival of days between COVID-19..