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All Studies   Meta Analysis    Recent:   

Multi-institutional Analysis of 505 COVID-19 Patients Supported with ECMO: Predictors of Survival

Hall et al., The Annals of Thoracic Surgery, doi:10.1016/j.athoracsur.2022.01.043
Feb 2022  
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Mortality 11% Improvement Relative Risk HCQ for COVID-19  Hall et al.  ICU PATIENTS Is very late treatment with HCQ beneficial for COVID-19? Retrospective 505 patients in the USA Lower mortality with HCQ (not stat. sig., p=0.31) c19hcq.org Hall et al., The Annals of Thoracic Su.., Feb 2022 FavorsHCQ Favorscontrol 0 0.5 1 1.5 2+
HCQ for COVID-19
1st treatment shown to reduce risk in March 2020
 
*, now with p < 0.00000000001 from 411 studies, recognized in 46 countries.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,300+ studies for 75 treatments. c19hcq.org
Retrospective 505 ECMO patients showing no significant difference in mortality in unadjusted results.
This study is excluded in the after exclusion results of meta analysis: unadjusted results with no group details.
risk of death, 11.2% lower, RR 0.89, p = 0.31, treatment 31 of 56 (55.4%), control 280 of 449 (62.4%), NNT 14.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Hall et al., 18 Feb 2022, retrospective, USA, peer-reviewed, 15 authors.
This PaperHCQAll
Multi-institutional Analysis of 505 Patients With Coronavirus Disease-2019 Supported With Extracorporeal Membrane Oxygenation: Predictors of Survival
Celeste A Hall, MD Jeffrey P Jacobs, MSA Alfred H Stammers, James D St. Louis, J W Awori Hayanga, MD Michael S Firstenberg, CCP Linda B Mongero, PhD Eric A Tesdahl, MD Keshava Rajagopal, PhD Faisal H Cheema, CCP Kirti Patel, CCP Tom Coley, CCP Anthony K Sestokas, PhD Marvin J Slepian, MD Vinay Badhwar
The Annals of Thoracic Surgery, doi:10.1016/j.athoracsur.2022.01.043
This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
References
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Barbaro, Maclaren, Boonstra, Extracorporeal membrane oxygenation support in COVID-19: an international cohort study of the Extracorporeal Life Support Organization registry, Lancet
Bartlett, Ogino, Brodie, Initial ELSO Guidance Document: ECMO for COVID-19 Patients with Severe Cardiopulmonary Failure, ASAIO J
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Jacobs, Falasa, Machuca, Commentary: Extracorporeal membrane oxygenation for patients with refractory Coronavirus Disease 2019: What do we know and what do we need to learn?, J Thorac Cardiovasc Surg
Jacobs, Stammers, Louis Etal, Extracorporeal Membrane Oxygenation in the Treatment of Severe Pulmonary and Cardiac Compromise in Coronavirus Disease 2019: Experience with 32 Patients, ASAIO J
Jacobs, Stammers, Louis, Multi-institutional Analysis of 100 Consecutive Patients with COVID-19 and Severe Pulmonary Compromise Treated with Extracorporeal Membrane Oxygenation: Outcomes and Trends Over Time, ASAIO J
Jacobs, Stammers, Louis, Multi-institutional Analysis of 200 COVID-19 Patients treated with ECMO: Outcomes and Trends, Ann Thorac Surg, doi:10.1016/j.athoracsur.2021.06.026
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Loyalka, Cheema, Rao, Rame, Rajagopal, Early Usage of Extracorporeal Membrane Oxygenation in the Absence of Invasive Mechanical Ventilation to Treat COVID-19-related Hypoxemic Respiratory Failure, ASAIO J
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Rajagopal, Keller, Akkanti, Advanced Pulmonary and Cardiac Support of COVID-19 Patients: Emerging Recommendations From ASAIO-A "Living Working Document, ASAIO J
Rajagopal, Keller, Akkanti, Advanced Pulmonary and Cardiac Support of COVID-19 Patients: Emerging Recommendations From ASAIO-a Living Working Document, Circ Heart Fail
Shih, Dimaio, Squiers, Venovenous extracorporeal membrane oxygenation for patients with refractory coronavirus disease 2019 (COVID-19): Multicenter experience of referral hospitals in a large health care system, J Thorac Cardiovasc Surg, doi:10.1016/j.jtcvs.2020.11.073
Shih, Squiers, Dimaio, Outcomes of Extracorporeal Membrane Oxygenation in Patients With Severe Acute Respiratory Distress Syndrome Caused by COVID-19 Versus Influenza, Ann Thorac Surg, doi:10.1016/j.athoracsur.2021.05.060
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Late treatment
is less effective
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