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All Studies   Meta Analysis    Recent:   

Hydroxychloroquine, azithromycin and methylprednisolone and in hospital survival in severe COVID-19 pneumonia

Go et al., Frontiers in Pharmacology, doi:10.3389/fphar.2022.935370
Sep 2022  
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Mortality 55% Improvement Relative Risk HCQ for COVID-19  Go et al.  LATE TREATMENT Is late treatment with HCQ + AZ beneficial for COVID-19? Retrospective study in the USA (March - June 2020) Lower mortality with HCQ + AZ (p=0.027) c19hcq.org Go et al., Frontiers in Pharmacology, Sep 2022 FavorsHCQ Favorscontrol 0 0.5 1 1.5 2+
HCQ for COVID-19
1st treatment shown to reduce risk in March 2020
 
*, now with p < 0.00000000001 from 411 studies, recognized in 46 countries.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,400+ studies for 79 treatments. c19hcq.org
Retrospective 759 hospitalized patients in the USA, showing lower mortality with combined HCQ+AZ+methylprednisolone treatment compared to methylprednisolone monotherapy.
risk of death, 55.0% lower, HR 0.45, p = 0.03, adjusted per study, multivariable, Cox proportional hazards.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Go et al., 27 Sep 2022, retrospective, USA, peer-reviewed, 2 authors, study period March 2020 - June 2020, this trial uses multiple treatments in the treatment arm (combined with AZ) - results of individual treatments may vary.
This PaperHCQAll
Hydroxychloroquine, azithromycin and methylprednisolone and in hospital survival in severe COVID-19 pneumonia
Ronaldo C Go, Themba Nyirenda
Frontiers in Pharmacology, doi:10.3389/fphar.2022.935370
Introduction: Severe COVID-19 pneumonia has two phases that are not mutually exclusive. Repurposed drugs target only one phase and the association of combination therapy to survival is unknown. Objective: To determine the association of hydroxychloroquine, azithromycin, and methylprednisolone versus methylprednisolone only to in hospital survival. Methods: This is a secondary analysis of a retrospective cohort of patients admitted for severe covid-19 in 13 hospitals in New Jersey, United States from March-June 2020. Propensity score match with 11 variables was constructed between those who received no methylprednisolone and methylprednisolone. Multivariate Cox regression was used for risk of in hospital mortality. Measurements and main results: There were 759 patients, 380 in no methylprednisolone and 379 with methylprednisolone. Multivariate Cox regression shows that methylprednisolone, hydroxychloroquine, and azithromycin had prolonged survival compared to methylprednisolone alone [HR 0.45 (95% CI 0.22,0.91 p < 0.03)]. In patients who received hydroxychloroquine and azithromycin, those who also received high dose methylprednisolone were associated with worse survival compared to those who received low dose methylprednisolone (HR = 1.642; 95% CI 1.053 to 2.562; p = 0.0287). Nursing home residents [HR 2.77 (95% CI 1.67, 4.59 p < 0.0001)], coronary artery disease [HR 2.93 (95% CI 1.31, 3.15 p = 0.001), and invasive mechanical ventilation [HR 3.02 (95% CI 1.71,5.34 p = 0.0001)] were independently associated with worse survival.
Ethics statement The studies involving human participants were reviewed and approved by Hackensack Meridian Health Institutional Review Board. Written informed consent for participation was not required for this study in accordance with the national legislation and the institutional requirements. Author contributions RG developed the concept, performed data entry, analysis and wrote most of the manuscript. TN performed the statistics and wrote some of the manuscript. Conflict of interest RG receiving consulting fees to participate in research design on long term follow-up in COVID-19 sponsored by Hoffmann LaRoche -Genentech. The remaining author declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Publisher's note All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher. Supplementary material The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fphar. 2022.935370/full#supplementary-material
References
Al-Tarbsheh, Chong, Oweis, Saha, Feustel et al., SARS-CoV-2 viral shedding and transmission dynamics: Implications of WHO COVID-19 discharge guidelines, N. Engl. J. Med, doi:10.3389/fmed.2021.648660
Bellani, Laffey, Pham, Fan, Brochard et al., None
Brault, Zerbib, Kontar, Fouquet, Carpentier et al., None
Burnham, Janssen, Riches, Moss, Downey, None
Canzano, Brambilla, Porro, Cosentino, Tortorici et al., Platelet and endothelial activation as potential mechanisms behind the thrombotic complications of COVID-19 patients, JACC. Basic Transl. Sci, doi:10.1016/j.jacbts.2020.12.009
Cavalcanti, Zampieri, Rosa, Azevedo, Veiga et al., None
Chow, Rahnavard, Gomberg-Maitland, Chatterjee, Patodi et al., Association of early aspirin use with in-hospital mortality in patients with moderate COVID-19, JAMA Netw. Open, doi:10.1001/jamanetworkopen.2022.3890
Echeverría-Esnal, Martin-Ontiyuelo, Navarrete-Rouco, De-Antonio Cuscó, Ferrández et al., Azithromycin in the treatment of COVID-19: A review, Expert Rev. anti. Infect. Ther, doi:10.1080/14787210.2020.1813024
Fiolet, Guihur, Rebeaud, Mulot, Peiffer-Smadja et al., Effect of hydroxychloroquine with or without azithromycin on the mortality of coronavirus disease 2019 (COVID-19) patients: A systematic review and meta-analysis, Clin. Microbiol. Infect, doi:10.1016/j.cmi.2020.08.022
Go, Gong, Therapeutic anticoagulation with heparin in noncritically ill patients with covid-19, doi:10.1056/nejmoa2105911
Go, Shah, Nyirenda, Methylprednisolone and 60 Days in hospital survival in coronavirus disease 2019 pneumonia, Crit. Care Explor, doi:10.1097/CCE.0000000000000493
Gottlieb, Vaca, Paredes, Mera, Webb et al., Early remdesivir to prevent progression to severe COVID-19 in outpatients, N. Engl. J. Med, doi:10.1056/NEJMoa2116846
Grieco, Maggiore, Roca, Spinelli, Patel et al., Non-invasive ventilatory support and high-flow nasal oxygen as firstline treatment of acute hypoxemic respiratory failure and ARDS, Intensive Care Med, doi:10.1007/s00134-021-06459-2
Haudebourg, Perier, Tuffet, De Prost, Razazi et al., Respiratory mechanics of COVID-19-versus non-COVID-19-associated acute respiratory distress syndrome, Am. J. Respir. Crit. Care Med
Kalil, Patterson, Mehta, Tomashek, Wolfe et al., Baricitinib plus remdesivir for hospitalized adults with covid-19, N. Engl. J. Med, doi:10.1056/NEJMoa2031994
Mehta, Li, Goodwin, Risk factors associated with SARS-CoV-2 infections, hospitalization, and mortality among US nursing home residents, Frontiers in Pharmacology frontiersin
Milberg, Davis, Steinberg, Hudson, Improved survival of patients with acute respiratory distress syndrome (ARDS): 1983-1993, JAMA, doi:10.1001/jama.1995.03520280052039
Papoutsi, Giannakoulis, Xourgia, Routsi, Kotanidou, None
Patel, Decuir, Abrams, Campbell, Godfred-Cato et al., None
Rosenberg, Dufort, Udo, Wilberschied, Kumar et al., Association of treatment with hydroxychloroquine or azithromycin with in-hospital mortality in patients with COVID-19 in New York state, JAMA, doi:10.1001/jama.2020.8630
Réa-Neto, Bernardelli, Câmara, Reese, Queiroga et al., An open-label randomized controlled trial evaluating the efficacy of chloroquine/hydroxychloroquine in severe COVID-19 patients, N. Engl. J. Med, doi:10.1016/S0140-6736(21)00676-0
Siempos, Effect of timing of intubation on clinical outcomes of critically ill patients with COVID-19: A systematic review and meta-analysis of nonrandomized cohort studies, Crit. Care, doi:10.1186/s13054-021-03540-6
Sullivan, Zazzeron, Berra, Noninvasive respiratory support for COVID-19 patients: When, for whom, and how?, J. intensive care, doi:10.1186/s40560-021-00593-1
Tang, Bigelow, Sheikh, Peters, Zenilman et al., Outcomes of nursing home COVID-19 patients by initial symptoms and comorbidity: Results of universal testing of 1970 residents, J. Am. Med. Dir. Assoc, doi:10.1016/j.jamda.2020.10.011
Tobin, Laghi, Jubran, Kampen, Van De Vijver et al., Duration and key determinants of infectious virus shedding in hospitalized patients with coronavirus disease, Ann. Intensive Care, doi:10.1186/s13613-020-00724-1
Vincent, Bergeron, Benjannet, Chloroquine is a potent inhibitor of SARS coronavirus infection and spread, Virol. J, doi:10.1186/1743-422X-2-69
Wang, Cao, Zhang, Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro, Cell Res, doi:10.1038/s41422-020-0282-0
Weaver, Das, Saffaran, Yehya, Scott et al., High risk of patient self-inflicted lung injury in COVID-19 with frequently encountered spontaneous breathing patterns: A computational modelling study, doi:10.1186/s13613-021-00904-7
Yao, Ye, Zhang, Cui, Huang et al., In vitro antiviral activity and projection of optimized dosing design of hydroxychloroquine for the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Clin. Infect. Dis, doi:10.1093/cid/ciaa237
Zhou, Yang, Wang, A pneumonia outbreak associated with a new coronavirus of probable bat origin, Nature, doi:10.1038/s41586-020-2012-7
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Repurposed drugs target only one phase and the association of ' 'combination therapy to survival is unknown.</jats:p><jats:p><jats:bold>Objective:</jats:bold> ' 'To determine the association of hydroxychloroquine, azithromycin, and methylprednisolone ' 'versus methylprednisolone only to in hospital ' 'survival.</jats:p><jats:p><jats:bold>Methods:</jats:bold> This is a secondary analysis of a ' 'retrospective cohort of patients admitted for severe covid-19 in 13 hospitals in New Jersey, ' 'United States from March–June 2020. Propensity score match with 11 variables was constructed ' 'between those who received no methylprednisolone and methylprednisolone. Multivariate Cox ' 'regression was used for risk of in hospital ' 'mortality.</jats:p><jats:p><jats:bold>Measurements and main results:</jats:bold> There were ' '759 patients, 380 in no methylprednisolone and 379 with methylprednisolone. 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J.'}, { 'key': 'B35', 'doi-asserted-by': 'publisher', 'first-page': '269', 'DOI': '10.1038/s41422-020-0282-0', 'article-title': 'Remdesivir and chloroquine effectively inhibit the recently emerged ' 'novel coronavirus (2019-nCoV) in vitro', 'volume': '30', 'author': 'Wang', 'year': '2020', 'journal-title': 'Cell Res.'}, { 'key': 'B36', 'doi-asserted-by': 'publisher', 'first-page': '109', 'DOI': '10.1186/s13613-021-00904-7', 'article-title': 'High risk of patient self-inflicted lung injury in COVID-19 with ' 'frequently encountered spontaneous breathing patterns: A computational ' 'modelling study', 'volume': '11', 'author': 'Weaver', 'year': '2021', 'journal-title': 'Ann. Intensive Care'}, { 'key': 'B37', 'unstructured': 'World health organization (WHO) coronavirus disease 19 dashboard\n' ' World Health Organization'}, { 'key': 'B38', 'unstructured': 'World health organization (WHO) coronavirus disease 19 dashboard\n' ' World Health Organization'}, { 'key': 'B39', 'doi-asserted-by': 'publisher', 'first-page': '732', 'DOI': '10.1093/cid/ciaa237', 'article-title': 'In vitro antiviral activity and projection of optimized dosing design ' 'of hydroxychloroquine for the treatment of severe acute respiratory ' 'syndrome coronavirus 2 (SARS-CoV-2)', 'volume': '71', 'author': 'Yao', 'year': '2020', 'journal-title': 'Clin. Infect. Dis.'}, { 'key': 'B40', 'doi-asserted-by': 'publisher', 'first-page': '270', 'DOI': '10.1038/s41586-020-2012-7', 'article-title': 'A pneumonia outbreak associated with a new coronavirus of probable bat ' 'origin', 'volume': '579', 'author': 'Zhou', 'year': '2020', 'journal-title': 'Nature'}], 'container-title': 'Frontiers in Pharmacology', 'original-title': [], 'link': [ { 'URL': 'https://www.frontiersin.org/articles/10.3389/fphar.2022.935370/full', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2022, 9, 27]], 'date-time': '2022-09-27T05:18:32Z', 'timestamp': 1664255912000}, 'score': 1, 'resource': {'primary': {'URL': 'https://www.frontiersin.org/articles/10.3389/fphar.2022.935370/full'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2022, 9, 27]]}, 'references-count': 40, 'alternative-id': ['10.3389/fphar.2022.935370'], 'URL': 'http://dx.doi.org/10.3389/fphar.2022.935370', 'relation': {}, 'ISSN': ['1663-9812'], 'subject': ['Pharmacology (medical)', 'Pharmacology'], 'container-title-short': 'Front. Pharmacol.', 'published': {'date-parts': [[2022, 9, 27]]}}
Late treatment
is less effective
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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