Risk of Hospitalization for Covid-19 Outpatients Treated with Various Drug Regimens in Brazil: Comparative Analysis
Szente Fonseca et al.,
Risk of Hospitalization for Covid-19 Outpatients Treated with Various Drug Regimens in Brazil: Comparative..,
Travel Medicine and Infectious Disease, doi:10.1016/j.tmaid.2020.101906
64% lower hospitalization with HCQ. Retrospective 717 patients in Brazil with early treatment, adjusted OR 0.32, p=0.00081, for HCQ versus no medication, and OR 0.45, p=0.0065, for HCQ vs. anything else.
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risk of hospitalization, 64.0% lower, RR 0.36, p < 0.001, treatment 25 of 175 (14.3%), control 89 of 542 (16.4%), adjusted per study, odds ratio converted to relative risk, HCQ vs. nothing, primary outcome.
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risk of hospitalization, 50.5% lower, RR 0.49, p = 0.006, treatment 25 of 175 (14.3%), control 89 of 542 (16.4%), adjusted per study, odds ratio converted to relative risk, HCQ vs. anything else.
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Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
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Szente Fonseca et al., 31 Oct 2020, retrospective, Brazil, peer-reviewed, mean age 50.6, 10 authors, average treatment delay 4.6 days, dosage 400mg bid day 1, 400mg qd days 2-5.
Abstract: Journal Pre-proof
Risk of Hospitalization for Covid-19 Outpatients Treated with Various Drug Regimens
in Brazil: Comparative Analysis
Silvia Nunes Szente Fonseca, Anastasio Queiroz de Sousa, Alexandre Giandoni
Wolkoff, Marcelo Sampaio Moreira, Bruno Castro Pinto, Christianne Fernandes
Valente Takeda, Eduardo Rebouças, Ana Paula Vasconcellos Abdon, Anderson L.A.
Nascimento, Harvey A. Risch
PII:
S1477-8939(20)30402-6
DOI:
https://doi.org/10.1016/j.tmaid.2020.101906
Reference:
TMAID 101906
To appear in:
Travel Medicine and Infectious Disease
Received Date: 14 August 2020
Revised Date:
10 September 2020
Accepted Date: 26 October 2020
Please cite this article as: Szente Fonseca SN, Queiroz de Sousa A, Wolkoff AG, Moreira MS, Pinto
BC, Valente Takeda CF, Rebouças E, Vasconcellos Abdon AP, Nascimento ALA, Risch HA, Risk of
Hospitalization for Covid-19 Outpatients Treated with Various Drug Regimens in Brazil: Comparative
Analysis, Travel Medicine and Infectious Disease, https://doi.org/10.1016/j.tmaid.2020.101906.
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Silvia Nunes Szente Fonseca: Conceptualization, Investigation, Resources, Data Curation, Writing Original Draft, Project administration
Anastasio Queiroz de Sousa: Investigation, Resources, Data Curation, Writing - Review & Editing
Alexandre Giandoni Wolkoff: Conceptualization, Investigation, Resources, Data Curation, Writing Review & Editing, Project administration
Marcelo Sampaio Moreira: Investigation, Resources, Data Curation, Writing - Review & Editing
Bruno Castro Pinto: Investigation, Resources, Data Curation, Writing - Review & Editing
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Christianne Fernandes Valente Takeda: Investigation, Resources, Data Curation, Writing - Review &
Editing
Eduardo Rebouças: Investigation, Resources, Data Curation, Writing - Review & Editing
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Ana Paula Vasconcellos Abdon: Investigation, Resources, Data Curation, Writing - Review & Editing
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Anderson L. A. Nascimento: Investigation, Resources, Data Curation, Writing - Review & Editing
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Harvey A. Risch: Conceptualization, Investigation, Data Curation, Formal Analysis, Writing - Review &
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Risk of Hospitalization for Covid-19 Outpatients Treated with Various Drug
Regimens in Brazil: Comparative Analysis
Silvia Nunes Szente Fonseca 1, Anastasio Queiroz de Sousa 2, Alexandre Giandoni
Wolkoff 3, Marcelo Sampaio Moreira 3, Bruno Castro Pinto 3, Christianne Fernandes Valente
Takeda 3, Eduardo Rebouças 3, Ana Paula Vasconcellos Abdon 4, Anderson L. A.
Nascimento 3, Harvey A. Risch 5, 6
Hospital São Francisco, Ribeirão Preto, Brazil
2
Federal University of Ceará, Ceará , Brazil
3
Hapvida Saúde HMO, Fortaleza, Brazil
4
University of Fortaleza, Fortaleza, Brazil
5
Yale School of Public Health, New Haven, Connecticut USA
6
Correspondence to: Harvey A. Risch, M.D., Ph.D., Yale School of Public Health, 60
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College St., PO..
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