Abstract: Journal of Global Antimicrobial Resistance 23 (2020) 1–3 Contents lists available at ScienceDirect Journal of Global Antimicrobial Resistance journal homepage: www.elsevier.com/locate/jgar Short Communication A comprehensive strategy for the early treatment of COVID-19 with azithromycin/hydroxychloroquine and/or corticosteroids: Results of a retrospective observational study in the French overseas department of Réunion Island Arthur Duberneta , Kevin Larsena , Laurie Massea , Jérôme Allynb,c , Emilie Focha , Lea Bruneaud,e, Adrien Maillote, Marie Lagrange-Xelotf , Vincent Thomasg , Marie-Christine Jaffar-Bandjeeg , Loraine Gauzereh , Loic Raffrayh , Karine Borsui , Servane Dibernardoi , Stéphane Renaudj , Michel Andréa , Diane Moreaua , Julien Jabotb , Nathalie Coolen-Alloua , Nicolas Alloub,c,* a Pneumologie, Centre Hospitalier Universitaire Felix-Guyon, Allée des Topazes, 97405 Saint Denis, Réunion Island, France Réanimation polyvalente, Centre Hospitalier Universitaire Felix-Guyon, Allée des Topazes, 97405 Saint Denis, Réunion Island, France c Département d’Informatique Clinique, Centre Hospitalier Universitaire Felix-Guyon, Allée des Topazes, 97405 Saint Denis, Réunion Island, France d INSERM CIC 1410 Clinical and Epidemiology, University Hospital, Saint Pierre, Réunion Island, France e Department of Public Health and Research Support, Methodological Support and Biostatistics Unit, University Hospital, Saint Denis, Réunion Island, France f Service des Maladies Infectieuses, Centre Hospitalier Universitaire Felix-Guyon, Allée des Topazes, 97405 Saint Denis, Réunion Island, France g Microbiologie, Centre Hospitalier Universitaire Felix-Guyon, Allée des Topazes, 97405 Saint Denis, Réunion Island, France h Médecine Interne, Centre Hospitalier Universitaire Felix-Guyon, Allée des Topazes, 97405 Saint Denis, Réunion Island, France i Médecine Polyvalente, Centre Hospitalier Universitaire Felix-Guyon, Allée des Topazes, 97405 Saint Denis, Réunion Island, France j Gériatrie, Centre Hospitalier Universitaire Felix-Guyon, Allée des Topazes, 97405 Saint Denis, Réunion Island, France b A R T I C L E I N F O A B S T R A C T Article history: Received 11 June 2020 Received in revised form 22 July 2020 Accepted 1 August 2020 Available online 20 August 2020 Background: This study aimed to evaluate the prognosis of COVID-19 patients in Reunion Island, with a particular focus on the management of patients with hypoxemic pneumonia. Methods: This retrospective observational study was conducted from 11 March to 17 April 2020 at the only hospital authorized to manage patients with COVID-19 in Reunion Island. Results: Over the study period, 164 out of 398 patients (41.2%) infected with COVID-19 were admitted to Félix Guyon University Hospital. Of these, 36 (22%) developed hypoxemic pneumonia. Patients with hypoxemic pneumonia were aged 66 [56–77] years, 69% were male and 33% had hypertension. Ten patients (27.8%) were hospitalized in intensive care unit (ICU). Hydroxychloroquine/azithromycin treatment was associated with a lower ICU admission rate (P = 0.008). None of the 6 patients treated with corticosteroids were hospitalized in ICU (P = 0.16). There were no deaths at follow up (minimum 80 days). Conclusions: Despite the risk profile of COVID-19 patients with severe hypoxemic pneumonia, the mortality rate of the disease in Reunion Island was 0%. This may be due to the care bundle used in our hospital (early hospitalisation, treatment with..