Clinical and Demographic Characteristics of COVID-19 Patients Admitted in a Tertiary Care Hospital in the Dominican Republic

{ 'institution': [{'name': 'medRxiv'}], 'indexed': {'date-parts': [[2022, 3, 30]], 'date-time': '2022-03-30T03:10:45Z', 'timestamp': 1648609845346}, 'posted': {'date-parts': [[2020, 12, 14]]}, 'group-title': 'Infectious Diseases (except HIV/AIDS)', 'reference-count': 25, 'publisher': 'Cold Spring Harbor Laboratory', 'content-domain': {'domain': [], 'crossmark-restriction': False}, 'accepted': {'date-parts': [[2020, 12, 14]]}, 'abstract': '<jats:title>Abstract</jats:title><jats:p>To present clinical and demographic characteristics ' 'of COVID-19 patients admitted to Hospital Metropolitano de Santiago in Dominican Republic, we ' 'analyzed electronic medical records of all hospitalized patients clinically admitted as viral ' 'pneumonia through March - April, 2020. Of 374 patients, 150 (40.1%) laboratory confirmed, ' 'were included in this study. Most of the patients were men (104 / 69.3%) with a median (IQR ' '44 - 66) age of 54. Hypertension (83 / 55.3%) and diabetes mellitus (49 / 32.7%) were the ' 'most common comorbidities, whereas fever (120 / 80%), cough (79 / 52.7%) and fatigue (60 / ' '40%) were the most common presenting symptoms. 28 (18.7%) patients required admission to the ' 'intensive care unit, of them, 26 patients (17.3%) required mechanical ventilation. The ' 'overall mortality rate was 10.7% Higher levels of inflammatory markers were associated with ' 'longer length of stay (LOS). This findings indulge information that could contribute to ' 'stratify patients at higher risk of complications.</jats:p>', 'DOI': '10.1101/2020.12.11.20247437', 'type': 'posted-content', 'created': { 'date-parts': [[2020, 12, 17]], 'date-time': '2020-12-17T07:15:52Z', 'timestamp': 1608189352000}, 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'Clinical and Demographic Characteristics of COVID-19 Patients Admitted in a Tertiary Care ' 'Hospital in the Dominican Republic', 'prefix': '10.1101', 'author': [ { 'ORCID': 'http://orcid.org/0000-0001-5156-3776', 'authenticated-orcid': False, 'given': 'David', 'family': 'De Luna', 'sequence': 'first', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0002-4024-9033', 'authenticated-orcid': False, 'given': 'Yori', 'family': 'Roque', 'sequence': 'additional', 'affiliation': []}, {'given': 'Nicolás', 'family': 'Batlle', 'sequence': 'additional', 'affiliation': []}, {'given': 'Katherine', 'family': 'Gómez', 'sequence': 'additional', 'affiliation': []}, {'given': 'Miguelina', 'family': 'Jáquez', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0001-5610-4624', 'authenticated-orcid': False, 'given': 'Brinia', 'family': 'Cabrera', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0001-7907-4501', 'authenticated-orcid': False, 'given': 'Lissa', 'family': 'de la Cruz', 'sequence': 'additional', 'affiliation': []}, {'given': 'Osvaldo', 'family': 'Tavárez', 'sequence': 'additional', 'affiliation': []}, {'given': 'Rossy', 'family': 'Belliard', 'sequence': 'additional', 'affiliation': []}, {'given': 'José Javier', 'family': 'Sanchez', 'sequence': 'additional', 'affiliation': []}], 'member': '246', 'reference': [ { 'key': '2021011111340076000_2020.12.11.20247437v1.1', 'unstructured': 'Timeline of WHO’s Response to COVID [internet]. Geneva (CH): World ' 'Health Organization. c2020-[cited 2020 Oct 5]. ' 'https://www.who.int/news-room/detail/29-06-2020-covidtimeline'}, { 'key': '2021011111340076000_2020.12.11.20247437v1.2', 'unstructured': 'John Hopkins Coronavirus Resource Center [internet]. Baltimore (MD): ' 'Johns Hopkins University of Medicine. c2020-[cited 2020 Dec 10]. ' 'https://coronavirus.jhu.edu'}, { 'key': '2021011111340076000_2020.12.11.20247437v1.3', 'unstructured': 'Boletín #264 Enfermedad por coronavirus 2019 [internet]. Santo Domingo ' '(RD): Gobierno de la República Dominicana, Salud Pública. Dirección ' 'General de Epidemiología. c2020-[cited 2020 Dec 10]. ' 'https://www.msp.gob.do/web/wp-content/uploads/2020/12/Boletin-COVID-19-no.264.pdf'}, { 'key': '2021011111340076000_2020.12.11.20247437v1.4', 'unstructured': 'World population [internet]. United States (USA): Worldometer. c2020 ' '[cited 2020 Oct 8]. https://www.worldometers.info/world-population/'}, { 'key': '2021011111340076000_2020.12.11.20247437v1.5', 'doi-asserted-by': 'crossref', 'unstructured': 'Zhang J , Dong X , Can Y , Yuan Y , Yang Y , Yan Y , et al. Clinical ' 'characteristics of 140 patients infected with SARS-CoV-2 in Wuhan, ' 'China. Allergy. [Internet]. 2020 Feb [cited 2020 Sep 15] ' 'https://onlinelibrary.wiley.com/doi/10.1111/all.14238', 'DOI': '10.1111/all.14238'}, { 'key': '2021011111340076000_2020.12.11.20247437v1.6', 'unstructured': 'Guang W , Ni Z , Hu Y , Liang W , Ou C , He J , et al.; The China ' 'Medical Treatment Expert Group for Covid-19. Clinical Characteristics of ' 'Coronavirus Disease 2019 in China. N Engl J Med.[Internet]. 2020 Feb ' '[cited 2020 Sep 15] https://www.nejm.org/doi/full/10.1056/nejmoa2002032'}, { 'key': '2021011111340076000_2020.12.11.20247437v1.7', 'doi-asserted-by': 'crossref', 'unstructured': 'Richardson S , Hirsch J , Narasimhan M , Crawford J , McGinn T , ' 'Davidson K , and the Northwell COVID-19 Research Consortium. Presenting ' 'Characteristics, Comorbidities, and Outcomes Among 5700 Patients ' 'Hospitalized With COVID-19 in the New York City Area. JAMA. [Internet]. ' '2020 Apr [cited 2020 Sep 16] ' 'https://jamanetwork.com/journals/jama/fullarticle/2765184', 'DOI': '10.1001/jama.2020.6775'}, { 'key': '2021011111340076000_2020.12.11.20247437v1.8', 'doi-asserted-by': 'crossref', 'unstructured': 'Grasselli G , Zangrillo A , Zanella A , Antonelli M , Cabrini L , ' 'Castelli A , et al.; The COVID-19 Lombardy ICU Network. Baseline ' 'characteristics and outcomes of 1591 patients infected with SARS-CoV-2 ' 'admitted to ICUs of the Lombardy region, Italy. JAMA. [Internet] 2020 ' 'Apr [cited 2020 Sep 16] ' 'https://jamanetwork.com/journals/jama/fullarticle/2764365', 'DOI': '10.1001/jama.2020.5394'}, { 'key': '2021011111340076000_2020.12.11.20247437v1.9', 'doi-asserted-by': 'crossref', 'unstructured': 'Berenguer J , Ryan P , Rodríguez-Baño J , Jarrín I , Carratalá J , ' 'Pachón J , et al.; The COVID-19@Spain Study Group. Characteristics and ' 'predictors of death among 4035 consecutively hospitalized patients with ' 'COVID-19 in Spain. CMI. [Internet] 2020 Nov [cited 2020 Sep 28] ' 'https://doi.org/10.1016/j.cmi.2020.07.024', 'DOI': '10.1016/j.cmi.2020.07.024'}, { 'key': '2021011111340076000_2020.12.11.20247437v1.10', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/S0140-6736(20)30566-3'}, { 'key': '2021011111340076000_2020.12.11.20247437v1.11', 'doi-asserted-by': 'publisher', 'DOI': '10.1056/NEJMc2010419'}, { 'key': '2021011111340076000_2020.12.11.20247437v1.12', 'unstructured': 'Chen, J. , Lu, H. , Melino, G. et al. COVID-19 infection: the China and ' 'Italy perspectives. Cell Death Dis. [Internet] 2020 Jun [cited 2020 Oct ' '5]. https://www.nature.com/articles/s41419-020-2603-0#citeas'}, { 'key': '2021011111340076000_2020.12.11.20247437v1.13', 'doi-asserted-by': 'publisher', 'DOI': '10.2807/1560-7917.ES.2020.25.16.2000460'}, { 'key': '2021011111340076000_2020.12.11.20247437v1.14', 'doi-asserted-by': 'publisher', 'DOI': '10.1007/s42399-020-00393-y'}, { 'key': '2021011111340076000_2020.12.11.20247437v1.15', 'doi-asserted-by': 'publisher', 'DOI': '10.1111/joim.13089'}, { 'key': '2021011111340076000_2020.12.11.20247437v1.16', 'doi-asserted-by': 'crossref', 'unstructured': 'Baqui P , Bica I , Marra V , Ercole A , van der Schaar M. Ethnic and ' 'regional variations in hospital mortality from COVID-19 in Brazil: a ' 'cross-sectional observational study. Lancet. [Internet] 2020 Jul [cited ' '2020 Oct 14] ' 'https://www.thelancet.com/journals/langlo/article/PIIS2214-109X(20)30285-0/fulltext#', 'DOI': '10.1101/2020.05.19.20107094'}, { 'key': '2021011111340076000_2020.12.11.20247437v1.17', 'doi-asserted-by': 'crossref', 'unstructured': 'Gautret P , Lagier JC , Parola P , Hoang VT , Meddeb L , Mailhe M , et ' 'al.; Hydroxychloroquine and azithromycin as a treatment of COVID-19: ' 'results of an open-label non-randomized clinical trial. medRxiv ' '[Preprint]. 2020 [cited 2020 Oct 15] doi: ' 'https://doi.org/10.1101/2020.03.16.20037135', 'DOI': '10.1101/2020.03.16.20037135'}, { 'key': '2021011111340076000_2020.12.11.20247437v1.18', 'doi-asserted-by': 'publisher', 'DOI': '10.26355/eurrev_202003_20706'}, { 'key': '2021011111340076000_2020.12.11.20247437v1.19', 'unstructured': 'Roche [Internet]. Basel: Hoffmann-La Roche; c2020 [cited 2020 Oct 15] ' 'Roche provides an update on the phase III COVACTA trial of ' 'Actemra/RoActemra in hospitalised patients with severe COVID-19 ' 'associated pneumonia; [about 6 screens]. ' 'https://www.roche.com/investors/updates/inv-update-2020-07-29.htm'}, { 'key': '2021011111340076000_2020.12.11.20247437v1.20', 'doi-asserted-by': 'crossref', 'unstructured': 'Xu X , Han M , Li T , Sun W , Wang D , Fu B , et al.; Effective ' 'treatment of severe COVID-19 patients with tocilizumab. PNAS. [Internet] ' '2020 May [cited 2020 Oct 15 ' 'https://www.pnas.org/content/pnas/117/20/10970.full.pdf', 'DOI': '10.1073/pnas.2005615117'}, { 'key': '2021011111340076000_2020.12.11.20247437v1.21', 'unstructured': 'Rodríguez-Baño J , Pachón J , Carratalá J , Ryan P , Jarrín I , Yllescas ' 'M , et al.; the SAM-COVID Study Group. Treatment with tocilizumab or ' 'corticosteroids for COVID-19 patients with hyperinflammatory state: a ' 'multicentre cohort study (SAM-COVID-19), CMI. Forthcoming 2020'}, { 'key': '2021011111340076000_2020.12.11.20247437v1.22', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.jmii.2020.05.013'}, { 'key': '2021011111340076000_2020.12.11.20247437v1.23', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.jinf.2020.05.046'}, { 'key': '2021011111340076000_2020.12.11.20247437v1.24', 'doi-asserted-by': 'publisher', 'DOI': '10.15406/jhvrv.2016.03.00085'}, { 'key': '2021011111340076000_2020.12.11.20247437v1.25', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.ijid.2020.05.115'}], 'container-title': [], 'original-title': [], 'link': [ { 'URL': 'https://syndication.highwire.org/content/doi/10.1101/2020.12.11.20247437', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2021, 1, 14]], 'date-time': '2021-01-14T10:34:49Z', 'timestamp': 1610620489000}, 'score': 1, 'resource': {'primary': {'URL': 'http://medrxiv.org/lookup/doi/10.1101/2020.12.11.20247437'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2020, 12, 14]]}, 'references-count': 25, 'URL': 'http://dx.doi.org/10.1101/2020.12.11.20247437', 'relation': {}, 'published': {'date-parts': [[2020, 12, 14]]}, 'subtype': 'preprint'}