Clinical and Demographic Characteristics of COVID-19 Patients Admitted in a Tertiary Care Hospital in the Dominican Republic
De Luna et al.,
Clinical and Demographic Characteristics of COVID-19 Patients Admitted in a Tertiary Care Hospital in the..,
medRxiv, doi:10.1101/2020.12.11.20247437 (Preprint)
Retrospective 150 patients in the Dominican Republic, 132 treated with HCQ, showing higher mortality with treatment in unadjusted results.
Confounding by indication is likely.
This study is excluded in the after exclusion results of meta
analysis:
unadjusted results with no group details; substantial unadjusted
confounding by indication likely.
risk of death, 104.5% higher, RR 2.05, p = 0.69, treatment 15 of 132 (11.4%), control 1 of 18 (5.6%).
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Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
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De Luna et al., 14 Dec 2020, retrospective, Dominican Republic, preprint, 10 authors.
Abstract: medRxiv preprint doi: https://doi.org/10.1101/2020.12.11.20247437; this version posted December 14, 2020. The copyright holder for this
preprint (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
It is made available under a CC-BY-NC-ND 4.0 International license .
Clinical and Demographic Characteristics of COVID-19 Patients Admitted in
a Tertiary Care Hospital in the Dominican Republic
Authors: David De Luna1, Yori Roque1, Nicolás Batlle1, Katherine Gómez1, Miguelina Jáquez1,
Brinia Cabrera1, Lissa de la Cruz1, Osvaldo,Tavárez1, Rossy Belliard1, José Javier Sanchez2
Affiliations:
1 HOMS - COVID Study Team, Hospital Metropolitano de Santiago, Santiago de los Caballeros, Dominican
Republic
2 Pontificia Universidad Católica Madre y Maestra, Santiago de los Caballeros, Dominican Republic
Abstract
To present clinical and demographic characteristics of COVID-19 patients admitted to Hospital
Metropolitano de Santiago in Dominican Republic, we analyzed electronic medical records of all
hospitalized patients clinically admitted as viral pneumonia through March - April, 2020. Of 374
patients, 150 (40.1%) laboratory confirmed, were included in this study. Most of the patients
were men (104 / 69.3%) with a median (IQR 44 - 66) age of 54. Hypertension (83 / 55.3%) and
diabetes mellitus (49 / 32.7%) were the most common comorbidities, whereas fever (120 / 80%),
cough (79 / 52.7%) and fatigue (60 / 40%) were the most common presenting symptoms. 28
(18.7%) patients required admission to the intensive care unit, of them, 26 patients (17.3%)
required mechanical ventilation. The overall mortality rate was 10.7% Higher levels of
inflammatory markers were associated with longer length of stay (LOS). This findings indulge
information that could contribute to stratify patients at higher risk of complications.
Background
By the end of 2019, the world began to confront numerous cases of viral pneumonia, initially
detected in Wuhan, China, which quickly spread all around the globe, becoming a pandemic.1
Since its naming and further description, much is known about SARS-CoV-2 and its associated
disease, COVID - 19, allowing health personnel a better understanding of its dynamics and
outcomes. To date, almost a year after these first cases, more than 70 million people have been
affected, and more thank 1,5 million have died.2 Recently, several drugs have demonstrated
beneficial effects in COVID-19, including antivirals that can reduce viral replication and lessens
the length of stay, but none have been able to prevent new infections or act as post exposure
prophylactic agent.
NOTE: This preprint reports new research that has not been certified by peer review and should not be used to guide clinical practice.
medRxiv preprint doi: https://doi.org/10.1101/2020.12.11.20247437; this version posted December 14, 2020. The copyright holder for this
preprint (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
It is made available under a CC-BY-NC-ND 4.0 International license .
The Dominican Republic (DR) has been struggling with COVID-19 since the first confirmed
case back in March 2020, in an italian tourist in the northern part of the country. By then, the
country was in the middle of an electoral process, which is believed contributed to the rapid
propagation and community transmission of..
Late treatment
is less effective
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be used based on risk/benefit analysis. No treatment, vaccine, or intervention
is 100% available and effective for all current and future variants. We do not
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