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All Studies   Meta Analysis    Recent:   
0 0.5 1 1.5 2+ Mortality 46% Improvement Relative Risk HCQ for COVID-19  Coll et al.  LATE TREATMENT Is late treatment with HCQ beneficial for COVID-19? Retrospective 635 patients in Spain Lower mortality with HCQ (p=0.000018) c19hcq.org Coll et al., American J. Transplantation, Oct 2020 Favors HCQ Favors control

Covid-19 in transplant recipients: the spanish experience

Coll et al., American Journal of Transplantation, doi:10.1111/ajt.16369
Oct 2020  
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HCQ for COVID-19
1st treatment shown to reduce risk in March 2020
 
*, now known with p < 0.00000000001 from 421 studies, recognized in 42 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
3,800+ studies for 60+ treatments. c19hcq.org
Retrospective 652 transplant recipient patients in Spain showing 46% lower mortality for patients treated with HCQ, unadjusted relative risk RR 0.54, p<0.0001.
This study is excluded in the after exclusion results of meta analysis: unadjusted results with no group details.
risk of death, 45.6% lower, RR 0.54, p < 0.001, treatment 55 of 307 (17.9%), control 108 of 328 (32.9%), NNT 6.7.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Coll et al., 23 Oct 2020, retrospective, Spain, peer-reviewed, median age 61.0, 29 authors.
This PaperHCQAll
COVID-19 in transplant recipients: The Spanish experience
Elisabeth Coll, Mario Fernández-Ruiz, J Emilio Sánchez-Álvarez, José R Martínez-Fernández, Orcid ID Marta Crespo, Jorge Gayoso, Teresa Bada-Bosch, Federico Oppenheimer, Francesc Moreso, María O López-Oliva, Edoardo Melilli, Marisa L Rodríguez-Ferrero, Carlos Bravo, Elena Burgos, Carme Facundo, Inmaculada Lorenzo, Íñigo Yañez, Cristina Galeano, Ana Roca, Mercedes Cabello, Manuel Gómez-Bueno, Madolores García-Cosío, Javier Graus, Laura Lladó, Alicia De Pablo, Carmelo Loinaz, Beatriz Aguado, Domingo Hernández, Orcid ID Beatriz Domínguez-Gil
American Journal of Transplantation, doi:10.1111/ajt.16369
Group for the Study of Infection in Transplantation and the Immunocompromised Host (GESITRA-IC) of the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC).
DISCLOSURE The authors of this manuscript have no conflicts of interest to disclose as described by the American Journal of Transplantation. DATA AVAILABILITY STATEMENT The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions. Accepted Article TABLES Table 1 . Baseline characteristics of solid organ and hematopoietic stem cell transplant recipients with COVID-19 and therapies used, overall and according to the transplant type a . BASELINE Accepted Article This article is protected by copyright. All rights reserved Accepted Article This article is protected by copyright. All rights reserved a Protease inhibitors in any combination. b Defined as the administration of bolus of corticosteroids, initiation of corticosteroids, or increase of baseline doses. ARDS: acute respiratory distress syndrome; AZT: azithromycin; HCQ: hydroxychloroquine. Accepted Article This article is protected by copyright. All rights reserved
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Late treatment
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