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Covid-19 in transplant recipients: the spanish experience

Coll et al., American Journal of Transplantation, doi:10.1111/ajt.16369
Oct 2020  
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Mortality 46% Improvement Relative Risk HCQ for COVID-19  Coll et al.  LATE TREATMENT Is late treatment with HCQ beneficial for COVID-19? Retrospective 635 patients in Spain Lower mortality with HCQ (p=0.000018) c19hcq.org Coll et al., American J. Transplantation, Oct 2020 FavorsHCQ Favorscontrol 0 0.5 1 1.5 2+
HCQ for COVID-19
1st treatment shown to reduce risk in March 2020, now with p < 0.00000000001 from 419 studies, recognized in 46 countries.
No treatment is 100% effective. Protocols combine treatments.
5,100+ studies for 112 treatments. c19hcq.org
Retrospective 652 transplant recipient patients in Spain showing 46% lower mortality for patients treated with HCQ, unadjusted relative risk RR 0.54, p<0.0001.
This study is excluded in the after exclusion results of meta analysis: unadjusted results with no group details.
risk of death, 45.6% lower, RR 0.54, p < 0.001, treatment 55 of 307 (17.9%), control 108 of 328 (32.9%), NNT 6.7.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Coll et al., 23 Oct 2020, retrospective, Spain, peer-reviewed, median age 61.0, 29 authors.
This PaperHCQAll
COVID-19 in transplant recipients: The Spanish experience
Elisabeth Coll, Mario Fernández-Ruiz, J Emilio Sánchez-Álvarez, José R Martínez-Fernández, Orcid ID Marta Crespo, Jorge Gayoso, Teresa Bada-Bosch, Federico Oppenheimer, Francesc Moreso, María O López-Oliva, Edoardo Melilli, Marisa L Rodríguez-Ferrero, Carlos Bravo, Elena Burgos, Carme Facundo, Inmaculada Lorenzo, Íñigo Yañez, Cristina Galeano, Ana Roca, Mercedes Cabello, Manuel Gómez-Bueno, Madolores García-Cosío, Javier Graus, Laura Lladó, Alicia De Pablo, Carmelo Loinaz, Beatriz Aguado, Domingo Hernández, Orcid ID Beatriz Domínguez-Gil
American Journal of Transplantation, doi:10.1111/ajt.16369
Group for the Study of Infection in Transplantation and the Immunocompromised Host (GESITRA-IC) of the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC).
DISCLOSURE The authors of this manuscript have no conflicts of interest to disclose as described by the American Journal of Transplantation. DATA AVAILABILITY STATEMENT The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions. Accepted Article TABLES Table 1 . Baseline characteristics of solid organ and hematopoietic stem cell transplant recipients with COVID-19 and therapies used, overall and according to the transplant type a . BASELINE Accepted Article This article is protected by copyright. All rights reserved Accepted Article This article is protected by copyright. All rights reserved a Protease inhibitors in any combination. b Defined as the administration of bolus of corticosteroids, initiation of corticosteroids, or increase of baseline doses. ARDS: acute respiratory distress syndrome; AZT: azithromycin; HCQ: hydroxychloroquine. Accepted Article This article is protected by copyright. All rights reserved
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Late treatment
is less effective
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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