Conv. Plasma
Nigella Sativa
Peg.. Lambda

All HCQ studies
Meta analysis
Home COVID-19 treatment researchHCQHCQ (more..)
Melatonin Meta
Bromhexine Meta Metformin Meta
Budesonide Meta
Cannabidiol Meta Molnupiravir Meta
Colchicine Meta
Conv. Plasma Meta
Curcumin Meta Nigella Sativa Meta
Ensovibep Meta Nitazoxanide Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Peg.. Lambda Meta
Fluvoxamine Meta Quercetin Meta
Hydroxychlor.. Meta Remdesivir Meta
Ivermectin Meta
Lactoferrin Meta

All Studies   Meta Analysis   Recent:  
0 0.5 1 1.5 2+ Mortality 43% Improvement Relative Risk HCQ for COVID-19  Bousquet et al.  LATE TREATMENT Is late treatment with HCQ beneficial for COVID-19? Prospective study of 108 patients in France Lower mortality with HCQ (not stat. sig., p=0.15) Bousquet et al., Aging, 11306-11313, Jun 2020 Favors HCQ Favors control

ADL-dependency, D-Dimers, LDH and absence of anticoagulation are independently associated with one-month mortality in older inpatients with Covid-19

Bousquet et al., Aging, 12:12, 11306-11313, doi:10.18632/aging.103583
Jun 2020  
  Source   PDF   All Studies   Meta AnalysisMeta
Observational prospective 108 hospitalized patients 65 and older, showing HCQ mortality OR 0.49, p = 0.15.
risk of death, 42.8% lower, RR 0.57, p = 0.15, treatment 5 of 27 (18.5%), control 23 of 81 (28.4%), NNT 10, adjusted per study, odds ratio converted to relative risk.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Bousquet et al., 23 Jun 2020, prospective, France, peer-reviewed, 10 authors.
All Studies   Meta Analysis   Submit Updates or Corrections
This PaperHCQAll
ADL-dependency, D-Dimers, LDH and absence of anticoagulation are independently associated with one-month mortality in older inpatients with Covid-19
Guilhem Bousquet, Géraldine Falgarone, David Deutsch, Sophie Derolez, Marilucy Lopez-Sublet, François-Xavier Goudot, Khadaoudj Amari, Yurdagul Uzunhan, Olivier Bouchaud, Frédéric Pamoukdjian
Background: To assess factors associated with one-month mortality among older inpatients with Covid-19. Results: The mean age was 78 ± 7.8 years, 55.5% were men, CT scan lung damage was observed in 76% of the patients (mild 23%, moderate 38%, extensive 22%, and severe 7%). The mortality rate was 26%. Dependency/Activities of Daily Living (ADL) score ≤ 5/6, D-Dimers, LDH, and no anticoagulation by reference for curative were independently associated with one-month mortality. A score derived from the multivariate model showed good calibration and very good discrimination (Harrell's C index [95%CI] = 0.83 [0.79-0.87]). Conclusion: ADL-dependency, high serum levels of D-Dimers and LDH and the absence of anticoagulation were independently associated with one-month mortality among older inpatients with Covid-19. Methods: 108 consecutive older inpatients aged 65 and over with Covid-19 confirmed by RT-PCR and/or typical CT chest scan were prospectively included in a French single-centre cohort study from March to April 2020. A systematic geriatric assessment was performed. Covariates were lymphocyte count, serum levels of albumin, C-Reactive Protein, D-Dimers and Lactate Dehydrogenase (LDH), anticoagulation level, and exposure to the hydroxychloroquine and azithromycin combined therapy. Cox uni-and multivariate proportional-hazard regressions were performed to identify predictors of one-month mortality.
AUTHOR CONTRIBUTIONS Conception and design: GB, GF, OB, FP Acquisition, analysis, or interpretation of data: All authors Drafting the work: GB, GF, FP Final approval: All authors Agreement to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved: All authors CONFLICTS OF INTEREST The authors have no conflicts of interest to disclose. SUPPLEMENTARY MATERIALS Supplementary Tables Supplementary Table 1 . The Cumulative Illness Rating Scale for Geriatrics (CIRS(G)) [15] . Disease
Angeli, Chouahnia, Canoui-Poitrine, Duchemann, Aparicio et al., Development, validation and clinical impact of a prediction model for 6-month mortality in older cancer patients: the GRADE, Aging, doi:10.18632/aging.102876
Bhatraju, Ghassemieh, Nichols, Kim, Jerome et al., Covid-19 in critically ill patients in the seattle region -case series, N Engl J Med, doi:10.1056/NEJMoa2004500
Chen, Dai, Mo, Li, Ma et al., Clinical characteristics and outcomes of older patients with coronavirus disease 2019 (COVID-19) in Wuhan, China (2019): a single-centered, retrospective study, J Gerontol A Biol Sci Med Sci, doi:10.1093/gerona/glaa089
Cheng, Papenburg, Desjardins, Kanjilal, Quach et al., Diagnostic Testing for Severe Acute Respiratory Syndrome-Related Coronavirus 2: A Narrative Review, Ann Intern Med, doi:10.7326/M20-1301
Clément, Nassif, Léger, Marchan, Development and contribution to the validation of a brief french version of the yesavage geriatric depression scale
Collins, Reitsma, Altman, Moons, Transparent reporting of a multivariable prediction model for Individual Prognosis or Diagnosis (TRIPOD): the TRIPOD statement, J Clin Epidemiol, doi:10.1016/j.jclinepi.2014.11.010
Du, Liang, Yang, Wang, Cao et al., Predictors of mortality for patients with COVID-19 pneumonia caused by SARS-CoV-2: a prospective cohort study, Eur Respir J, doi:10.1183/13993003.00524-2020
Ellis, Langhorne, Comprehensive geriatric assessment for older hospital patients, Br Med Bull, doi:10.1093/bmb/ldh033
Fried, Tangen, Walston, Newman, Hirsch et al., Cardiovascular Health Study Collaborative Research Group. Frailty in older adults: evidence for a phenotype, J Gerontol A Biol Sci Med Sci, doi:10.1093/gerona/56.3.m146
Gautret, Lagier, Parola, Hoang, Meddeb et al., Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial, Int J Antimicrob Agents, doi:10.1016/j.ijantimicag.2020.105949
Hamming, Timens, Bulthuis, Lely, Navis et al., Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis, J Pathol, doi:10.1002/path.1570
Ji, Zhang, Xu, Chen, Yang et al., Prediction for progression risk in patients with COVID-19 pneumonia: the CALL score, Clin Infect Dis, doi:10.1093/cid/ciaa414
Katz, Downs, Cash, Grotz, Progress in development of the index of ADL, Gerontologist, doi:10.1093/geront/10.1_part_1.20
Klok, Kruip, Van Der Meer, Arbous, Gommers et al., Incidence of thrombotic complications in critically ill ICU patients with COVID-19, Thromb Res, doi:10.1016/j.thromres.2020.04.013
Kojima, Frailty as a predictor of disabilities among community-dwelling older people: a systematic review and meta-analysis, Disabil Rehabil, doi:10.1080/09638288.2016.1212282
Lawton, Brody, Assessment of older people: self-maintaining and instrumental activities of daily living, Gerontologist
Li, Fang, Li, Pan, Qin et al., CT image visual quantitative evaluation and clinical classification of coronavirus disease (COVID-19), Eur Radiol, doi:10.1007/s00330-020-06817-6
Li, Xu, Yu, Wang, Tao et al., Risk factors for severity and mortality in adult COVID-19 inpatients in Wuhan, J Allergy Clin Immunol, doi:10.1016/j.jaci.2020.04.006
Mehta, Mehta, Girman, Adhikari, Johnson, Regression coefficient-based scoring system should be used to assign weights to the risk index, J Clin Epidemiol, doi:10.1016/j.jclinepi.2016.03.031
Miller, Paradis, Houck, Mazumdar, Stack et al., Rating chronic medical illness burden in geropsychiatric practice and research: application of the cumulative illness rating scale, Psychiatry Res, doi:10.1016/0165-1781(92)90005-n
Raynaud-Simon, Revel-Delhom, Hébuterne, Nutrition, Program et al., Clinical practice guidelines from the French Health High Authority: nutritional support strategy in protein-energy malnutrition in the elderly, Clin Nutr, doi:10.1016/j.clnu.2010.12.003
Sanchez, Benhamou, Bertoletti, Constant, Couturaud et al., Recommandations de bonne pratique pour la prise en charge de la maladie veineuse thromboembolique chez l'adulte. Version courte, Rev Mal Respir, doi:10.1016/j.rmr.2019.01.003
Shahid, Kalayanamitra, Mcclafferty, Kepko, Ramgobin et al., COVID-19 and older adults: what we know, J Am Geriatr Soc, doi:10.1111/jgs.16472
Zhou, Yu, Du, Fan, Liu et al., Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study, Lancet, doi:10.1016/S0140-6736(20)30566-3
Late treatment
is less effective
Please send us corrections, updates, or comments. Vaccines and treatments are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop