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0 0.5 1 1.5 2+ Mortality 43% Improvement Relative Risk Bousquet et al. HCQ for COVID-19 LATE TREATMENT Is late treatment with HCQ beneficial for COVID-19? Prospective study of 108 patients in France Lower mortality with HCQ (not stat. sig., p=0.15) Bousquet et al., Aging, 12:12, 11306-11313, doi:10.18632/aging.103583 Favors HCQ Favors control
ADL-dependency, D-Dimers, LDH and absence of anticoagulation are independently associated with one-month mortality in older inpatients with Covid-19
Bousquet et al., Aging, 12:12, 11306-11313, doi:10.18632/aging.103583
Bousquet et al., ADL-dependency, D-Dimers, LDH and absence of anticoagulation are independently associated with one-month.., Aging, 12:12, 11306-11313, doi:10.18632/aging.103583
Jun 2020   Source   PDF  
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Observational prospective 108 hospitalized patients 65 and older, showing HCQ mortality OR 0.49, p = 0.15.
risk of death, 42.8% lower, RR 0.57, p = 0.15, treatment 5 of 27 (18.5%), control 23 of 81 (28.4%), NNT 10, adjusted per study, odds ratio converted to relative risk.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Bousquet et al., 23 Jun 2020, prospective, France, peer-reviewed, 10 authors.
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Abstract: AGING 2020, Vol. 12, No. 12 Research Paper ADL-dependency, D-Dimers, LDH and absence of anticoagulation are independently associated with one-month mortality in older inpatients with Covid-19 Guilhem Bousquet1,2, Géraldine Falgarone2,3, David Deutsch4,5, Sophie Derolez4,6, Marilucy Lopez-Sublet7, François-Xavier Goudot8, Khadaoudj Amari9, Yurdagul Uzunhan10,11, Olivier Bouchaud12,13,*,#, Frédéric Pamoukdjian2,9,*,# 1 AP-HP Hôpital Avicenne, Oncologie Médicale, Bobigny 93000, France Université Sorbonne Paris Nord, INSERM, U942, Cardiovascular Markers in Stressed Conditions, MASCOT, Bobigny 93000, France 3 AP-HP Hôpital Avicenne, Unité de Médecine Ambulatoire (UMA), Bobigny 93000, France 4 Université Sorbonne Paris Nord, Villetaneuse 93430, France 5 AP-HP Hôpital Avicenne, Gastroentérologie et Oncologie Digestive Bobigny 93000, France 6 AP-HP Hôpital Avicenne, Rhumatologie, Bobigny 93000, France 7 AP-HP Hôpital Avicenne, Médecine Interne, ESH Hypertension Excellence Centre, Bobigny 93000, France 8 AP-HP Hôpital Avicenne, Cardiologie, Bobigny 93000, France 9 APHP Hôpital Avicenne, Service de Médecine Gériatrique, Bobigny 93000, France 10 AP-HP Hôpital Avicenne, Pneumologie, Bobigny 93000, France 11 Université Sorbonne Paris Nord, INSERM, U1272, « Hypoxia and Lung », Bobigny 93000, France 12 AP-HP Hôpital Avicenne, Infectious Diseases, Bobigny 93000, France 13 EA 3412, Laboratoire Educations et Pratiques de Santé, Bobigny 93000, France *Equal contribution # Co-senior author 2 Correspondence to: Frédéric Pamoukdjian; email: Keywords: COVID-19, geriatric assessment, mortality, predictive biomarkers, anticoagulation Received: May 12, 2020 Accepted: June 12, 2020 Published: June 23, 2020 Copyright: Bousquet et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. ABSTRACT Background: To assess factors associated with one-month mortality among older inpatients with Covid-19. Results: The mean age was 78 ± 7.8 years, 55.5% were men, CT scan lung damage was observed in 76% of the patients (mild 23%, moderate 38%, extensive 22%, and severe 7%). The mortality rate was 26%. Dependency/Activities of Daily Living (ADL) score ≤ 5/6, D-Dimers, LDH, and no anticoagulation by reference for curative were independently associated with one-month mortality. A score derived from the multivariate model showed good calibration and very good discrimination (Harrell’s C index [95%CI] = 0.83 [0.79-0.87]). Conclusion: ADL-dependency, high serum levels of D-Dimers and LDH and the absence of anticoagulation were independently associated with one-month mortality among older inpatients with Covid-19. Methods: 108 consecutive older inpatients aged 65 and over with Covid-19 confirmed by RT-PCR and/or typical CT chest scan were prospectively included in a French single-centre cohort study from March to April 2020. A systematic geriatric assessment was performed. Covariates were lymphocyte count, serum levels of albumin, CReactive Protein, D-Dimers and Lactate Dehydrogenase (LDH), anticoagulation level, and exposure to the hydroxychloroquine and azithromycin combined therapy. Cox uni- and multivariate proportional-hazard regressions were performed to identify predictors of one-month..
Late treatment
is less effective
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