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All Studies   Meta Analysis    Recent:   

Efficacy and safety of chloroquine for treatment of COVID-19. An open-label, multi-center, non-randomized trial

Zhong Nanshan (钟南山)
Mar 2020  
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Virological cure at day 10 80% Improvement Relative Risk HCQ  Zhong Nanshan (钟南山) et al.  LATE TREATMENT Is late treatment with HCQ beneficial for COVID-19? Retrospective 197 patients in China Improved viral clearance with HCQ (p=0.0001) c19hcq.org Zhong Nanshan, March 2020 FavorsHCQ Favorscontrol 0 0.5 1 1.5 2+
HCQ for COVID-19
1st treatment shown to reduce risk in March 2020
 
*, now with p < 0.00000000001 from 411 studies, recognized in 46 countries.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,300+ studies for 75 treatments. c19hcq.org
197 patients. CQ effective. Day 10 viral RNA negative 91.4% HCQ versus 57.4% control. Median time to negative test 3 days versus 9 days for control.
risk of no virological cure at day 10, 80.0% lower, RR 0.20, p < 0.001, treatment 5 of 115 (4.3%), control 17 of 82 (20.7%), NNT 6.1, adjusted per study.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Zhong Nanshan (钟南山) et al., 26 Mar 2020, retrospective, China, preprint, 1 author.
This PaperHCQAll
Late treatment
is less effective
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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