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@CovidAnalysis
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Efficacy of Chloroquine and Lopinavir/ Ritonavir in mild/general novel coronavirus (CoVID-19) infections: a prospective, open-label, multicenter randomized controlled clinical study

Xia et al., ChiCTR2000029741
Feb 2020  
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Viral clearance 38% Improvement Relative Risk HCQ for COVID-19  Xia et al.  LATE TREATMENT Is late treatment with HCQ beneficial for COVID-19? Retrospective 25 patients in China Improved viral clearance with HCQ (not stat. sig., p=0.17) c19hcq.org Xia et al., ChiCTR2000029741, February 2020 FavorsHCQ Favorscontrol 0 0.5 1 1.5 2+
HCQ for COVID-19
1st treatment shown to reduce risk in March 2020, now with p < 0.00000000001 from 419 studies, recognized in 46 countries.
Lower risk for mortality, hospitalization, progression, recovery, cases, and viral clearance.
No treatment is 100% effective. Protocols combine treatments.
5,100+ studies for 112 treatments. c19hcq.org
Early results from a very small trial, reported within the application for a later trial. Very minimal details are provided, but we include this as the earliest published results. For COVID-19 patients with pneumonia the viral negative conversion rate was 50% (5/10) with CQ versus 20% (3/15) with lopinavir/ritonavir.
This study is excluded in the after exclusion results of meta analysis: minimal details provided.
Important missing comments or errors? Let us know.
risk of no viral clearance, 37.5% lower, RR 0.62, p = 0.17, treatment 5 of 10 (50.0%), control 12 of 15 (80.0%), NNT 3.3.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Xia et al., 11 Feb 2020, retrospective, China, preprint, 1 author.
This PaperHCQAll
Late treatment
is less effective
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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