Effects of hydroxychloroquine and azithromycin use on ECG parameters due to COVID-19 in pediatric patient population Pediatrik hasta popülasyonunda COVİD-19 sebebiyle hidroksiklorokin ve azitromisin kullanımın EKG
Bu Eser, Creative Commons, Uluslararası Telif Lisansı, Hakkı, Hatice Uygun, Mehmet Turgut, Celal Varan
Aim: Due to COVID-19 infection, the use of two drugs, hydroxychloroquine and azithromycin, with a high potential for arrhythmia, came to the fore in the pediatric patient group at the beginning of 2020, during the search for treatment. The aim is to reveal the synergistic arrhythmic effects of these two drugs in prolonging the QT interval on the ECG. Materials and Methods: First of all, patients taking hydroxychloroquine were identified. Demographic data of these patients were recorded. In addition to hydroxychloroquine, azithromycin and other treatments they used were also recorded. Those with ECG data were selected. Transmyocardial repolarization parameters calculated by ECG were calculated retrospectively (QT, QTc, Tpe, Tpe/QT, Tpe/QTc). Then, laboratory findings and radiological imaging of these patients were recorded. Results: Twenty-three pediatric patients who met the study criteria were identified. All of the patients were asymptomatic or mild disease. When initial and postdrug ECG parameters were compared; It was observed that the drugs did not have a significant arrhythmogenic effect on ECG parameters, especially QT interval and QTc. Conclusion: Unlike the literature showing arrhythmic effects of these drugs in adult COVID-19 disease, hydroxychloroquine and azithromycin did not show such an effect in the pediatric population.
Ethics Committee Approval Ethics committee approval was obtained with the decision of the Ethics Committee for Non-Interventional Procedures of Adıyaman University, dated and numbered 2020: 8/11. The study was conducted under the principles of the Declaration of Helsinki.
Informed Consent Data concerning the study were collected with the permission of the Adıyaman Provincial Health Directorate.
Authors Contrubituons
All of the authors contributed at every stage of the study
Conflict of Interests There is no conflict of interest to declare.
Financial Disclosure No person/organization is supporting this study financially.
Statements These research results have yet to be presented anywhere previously. Data related to the study is available on request.
Peer-review Externally peer-reviewed.
References
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'abstract': '<jats:p xml:lang="en">Aim: Due to COVID-19 infection, the use of two drugs, '
'hydroxychloroquine and azithromycin, with a high potential for arrhythmia, came to the fore '
'in the pediatric patient group at the beginning of 2020, during the search for treatment. The '
'aim is to reveal the synergistic arrhythmic effects of these two drugs in prolonging the QT '
'interval on the ECG.\n'
'Materials and Methods: First of all, patients taking hydroxychloroquine were identified. '
'Demographic data of these patients were recorded. In addition to hydroxychloroquine, '
'azithromycin and other treatments they used were also recorded. Those with ECG data were '
'selected. Transmyocardial repolarization parameters calculated by ECG were calculated '
'retrospectively (QT, QTc, Tpe, Tpe/QT, Tpe/QTc). Then, laboratory findings and radiological '
'imaging of these patients were recorded.\n'
'Results: Twenty-three pediatric patients who met the study criteria were identified. All of '
'the patients were asymptomatic or mild disease. When initial and post-drug ECG parameters '
'were compared; It was observed that the drugs did not have a significant arrhythmogenic '
'effect on ECG parameters, especially QT interval and QTc.\n'
'Conclusion: Unlike the literature showing arrhythmic effects of these drugs in adult COVID-19 '
'disease, hydroxychloroquine and azithromycin did not show such an effect in the pediatric '
'population.</jats:p>',
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