Abstract: Journal Pre-proof INCIDENCE OF ARRHYTHMIAS AND ELECTROCARDIOGRAPHIC ABNORMALITIES IN SYMPTOMATIC PEDIATRIC PATIENTS WITH PCR POSITIVE SARS-CoV-2 INFECTION INCLUDING DRUG INDUCED CHANGES IN THE CORRECTED QT INTERVAL (QTc). Sharmeen Samuel, MD, Richard A. Friedman, MD, Chetan Sharma, MD, Madhusudan Ganigara, MD, Elizabeth Mitchell, MD, Charles Schleien, MD, Andrew D. Blaufox, MD. PII: S1547-5271(20)30632-9 DOI: https://doi.org/10.1016/j.hrthm.2020.06.033 Reference: HRTHM 8462 To appear in: Heart Rhythm Received Date: 9 June 2020 Revised Date: 25 June 2020 Accepted Date: 29 June 2020 Please cite this article as: Samuel S, Friedman RA, Sharma C, Ganigara M, Mitchell E, Schleien C, Blaufox AD, INCIDENCE OF ARRHYTHMIAS AND ELECTROCARDIOGRAPHIC ABNORMALITIES IN SYMPTOMATIC PEDIATRIC PATIENTS WITH PCR POSITIVE SARS-CoV-2 INFECTION INCLUDING DRUG INDUCED CHANGES IN THE CORRECTED QT INTERVAL (QTc)., Heart Rhythm (2020), doi: https://doi.org/10.1016/j.hrthm.2020.06.033. This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. © 2020 Published by Elsevier Inc. on behalf of Heart Rhythm Society. INCIDENCE OF ARRHYTHMIAS AND ELECTROCARDIOGRAPHIC ABNORMALITIES IN SYMPTOMATIC PEDIATRIC PATIENTS WITH PCR POSITIVE SARS-CoV-2 INFECTION INCLUDING DRUG INDUCED CHANGES IN THE CORRECTED QT INTERVAL (QTc). Running Title: CARDIAC ELECTROPHYSIOLOGIC FINDINGS ASSOCIATED WITH PEDIATRIC COVID-19. 1,2 Sharmeen Samuel MD, 1,2 Richard A Friedman MD, 1,2 Chetan Sharma MD, 1,2 Madhusudan Ganigara MD, 1,2 Elizabeth Mitchell MD, 1Charles Schleien MD, 1,2 Andrew D Blaufox, MD. Affiliation of authors 1 Section of Pediatric Cardiology 2 Departments of Pediatrics Cohen Children’s Medical Center, Northwell Health System Donald and Barbara Zucker School of Medicine at Hofstra University Address of correspondence Sharmeen Samuel, MD. Division of Pediatric Cardiology 1111 Marcus Ave, 4B New Hyde Park, NY 11042 Fax no: (516) 601-7380 Email address: ssamuel21@northwell.edu CONFLICTS OF INTEREST: None WORD COUNT: 4913 ABSTRACT: 1 Background: There is limited data regarding the electrophysiological abnormalities and arrhythmias in children with COVID-19, including those associated with treatment using potentially pro-arrhythmic Hydroxychloroquine (HCQ) and Azithromycin (AZN). Objectives: To describe the electrophysiologic findings and arrhythmias associated with pediatric COVID-19 and its treatment. Methods: A single center retrospective chart review was undertaken and included all patients with 1) symptoms of COVID-19, and 2) PCR (+) nasopharyngeal swabs for SARS-CoV-2 who were placed on continuous telemetry for the duration of their hospitalization during March through May, 2020. Results: Thirty-six patients were included in the study. Significant arrhythmias were found in 6 (nonsustained (ns) ventricular tachycardia in 5 and sustained atrial tachycardia in 1). All were self-resolving and half prompted prophylactic anti-arrhythmic therapy. Patients..