Incidence of arrhythmias and electrocardiographic abnormalities in symptomatic pediatric patients with PCR positive SARS-CoV-2 infection including drug induced changes in the corrected QT interval (QTc)
Samuel et al.,
Incidence of arrhythmias and electrocardiographic abnormalities in symptomatic pediatric patients with PCR..,
Heart Rhythm, doi:10.1016/j.hrthm.2020.06.033
In pediatric patients with PCR positive active COVID-19 infection, significant arrhythmias are infrequent, but occur at an incidence higher than expected in a general pediatric population. Comorbidities are not more common in patients with arrhythmias than in patients without arrhythmias. However, providers still need to be vigilant for comorbidities that may independently place patients at risk for arrhythmias. COVID-19 treatment using HCQ leads to significant QTc prolongation, but was not associated with arrhythmias in pediatric patients. The long term sequelae of arrhythmia development in this population and their impact on outcome needs to be studied.
Samuel et al., 1 Jul 2020, peer-reviewed, 7 authors.
Abstract: Journal Pre-proof
INCIDENCE OF ARRHYTHMIAS AND ELECTROCARDIOGRAPHIC
ABNORMALITIES IN SYMPTOMATIC PEDIATRIC PATIENTS WITH PCR POSITIVE
SARS-CoV-2 INFECTION INCLUDING DRUG INDUCED CHANGES IN THE
CORRECTED QT INTERVAL (QTc).
Sharmeen Samuel, MD, Richard A. Friedman, MD, Chetan Sharma, MD,
Madhusudan Ganigara, MD, Elizabeth Mitchell, MD, Charles Schleien, MD, Andrew
D. Blaufox, MD.
PII:
S1547-5271(20)30632-9
DOI:
https://doi.org/10.1016/j.hrthm.2020.06.033
Reference:
HRTHM 8462
To appear in:
Heart Rhythm
Received Date: 9 June 2020
Revised Date:
25 June 2020
Accepted Date: 29 June 2020
Please cite this article as: Samuel S, Friedman RA, Sharma C, Ganigara M, Mitchell E, Schleien C,
Blaufox AD, INCIDENCE OF ARRHYTHMIAS AND ELECTROCARDIOGRAPHIC ABNORMALITIES IN
SYMPTOMATIC PEDIATRIC PATIENTS WITH PCR POSITIVE SARS-CoV-2 INFECTION INCLUDING
DRUG INDUCED CHANGES IN THE CORRECTED QT INTERVAL (QTc)., Heart Rhythm (2020), doi:
https://doi.org/10.1016/j.hrthm.2020.06.033.
This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition
of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of
record. This version will undergo additional copyediting, typesetting and review before it is published
in its final form, but we are providing this version to give early visibility of the article. Please note that,
during the production process, errors may be discovered which could affect the content, and all legal
disclaimers that apply to the journal pertain.
© 2020 Published by Elsevier Inc. on behalf of Heart Rhythm Society.
INCIDENCE OF ARRHYTHMIAS AND ELECTROCARDIOGRAPHIC ABNORMALITIES IN
SYMPTOMATIC PEDIATRIC PATIENTS WITH PCR POSITIVE SARS-CoV-2 INFECTION
INCLUDING DRUG INDUCED CHANGES IN THE CORRECTED QT INTERVAL (QTc).
Running Title: CARDIAC ELECTROPHYSIOLOGIC FINDINGS ASSOCIATED WITH PEDIATRIC
COVID-19.
1,2
Sharmeen Samuel MD, 1,2 Richard A Friedman MD, 1,2 Chetan Sharma MD, 1,2 Madhusudan Ganigara
MD, 1,2 Elizabeth Mitchell MD, 1Charles Schleien MD, 1,2 Andrew D Blaufox, MD.
Affiliation of authors
1
Section of Pediatric Cardiology
2
Departments of Pediatrics
Cohen Children’s Medical Center, Northwell Health System
Donald and Barbara Zucker School of Medicine at Hofstra University
Address of correspondence
Sharmeen Samuel, MD.
Division of Pediatric Cardiology
1111 Marcus Ave, 4B
New Hyde Park, NY 11042
Fax no: (516) 601-7380
Email address: ssamuel21@northwell.edu
CONFLICTS OF INTEREST: None
WORD COUNT: 4913
ABSTRACT:
1
Background: There is limited data regarding the electrophysiological abnormalities and arrhythmias in
children with COVID-19, including those associated with treatment using potentially pro-arrhythmic
Hydroxychloroquine (HCQ) and Azithromycin (AZN).
Objectives: To describe the electrophysiologic findings and arrhythmias associated with pediatric
COVID-19 and its treatment.
Methods: A single center retrospective chart review was undertaken and included all patients with 1)
symptoms of COVID-19, and 2) PCR (+) nasopharyngeal swabs for SARS-CoV-2 who were placed on
continuous telemetry for the duration of their hospitalization during March through May, 2020.
Results: Thirty-six patients were included in the study. Significant arrhythmias were found in 6 (nonsustained (ns) ventricular tachycardia in 5 and sustained atrial tachycardia in 1). All were self-resolving
and half prompted prophylactic anti-arrhythmic therapy. Patients..
Please send us corrections, updates, or comments. Vaccines and
treatments are complementary. All practical, effective, and safe means should
be used based on risk/benefit analysis. No treatment, vaccine, or intervention
is 100% available and effective for all current and future variants. We do not
provide medical advice. Before taking any medication, consult a qualified
physician who can provide personalized advice and details of risks and
benefits based on your medical history and situation.
FLCCC and
WCH
provide treatment protocols.
Submit