Incidence of arrhythmias and electrocardiographic abnormalities in symptomatic pediatric patients with PCR positive SARS-CoV-2 infection including drug induced changes in the corrected QT interval (QTc)
Samuel et al.
, Incidence of arrhythmias and electrocardiographic abnormalities in symptomatic pediatric patients with PCR..
, Heart Rhythm, doi:10.1016/j.hrthm.2020.06.033
In pediatric patients with PCR positive active COVID-19 infection, significant arrhythmias are infrequent, but occur at an incidence higher than expected in a general pediatric population. Comorbidities are not more common in patients with arrhythmias than in patients without arrhythmias. However, providers still need to be vigilant for comorbidities that may independently place patients at risk for arrhythmias. COVID-19 treatment using HCQ leads to significant QTc prolongation, but was not associated with arrhythmias in pediatric patients. The long term sequelae of arrhythmia development in this population and their impact on outcome needs to be studied.
Samuel et al., 1 Jul 2020, peer-reviewed, 7 authors.
Abstract: Journal Pre-proof
INCIDENCE OF ARRHYTHMIAS AND ELECTROCARDIOGRAPHIC
ABNORMALITIES IN SYMPTOMATIC PEDIATRIC PATIENTS WITH PCR POSITIVE
SARS-CoV-2 INFECTION INCLUDING DRUG INDUCED CHANGES IN THE
CORRECTED QT INTERVAL (QTc).
Sharmeen Samuel, MD, Richard A. Friedman, MD, Chetan Sharma, MD,
Madhusudan Ganigara, MD, Elizabeth Mitchell, MD, Charles Schleien, MD, Andrew
D. Blaufox, MD.
To appear in:
Received Date: 9 June 2020
25 June 2020
Accepted Date: 29 June 2020
Please cite this article as: Samuel S, Friedman RA, Sharma C, Ganigara M, Mitchell E, Schleien C,
Blaufox AD, INCIDENCE OF ARRHYTHMIAS AND ELECTROCARDIOGRAPHIC ABNORMALITIES IN
SYMPTOMATIC PEDIATRIC PATIENTS WITH PCR POSITIVE SARS-CoV-2 INFECTION INCLUDING
DRUG INDUCED CHANGES IN THE CORRECTED QT INTERVAL (QTc)., Heart Rhythm (2020), doi:
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© 2020 Published by Elsevier Inc. on behalf of Heart Rhythm Society.
INCIDENCE OF ARRHYTHMIAS AND ELECTROCARDIOGRAPHIC ABNORMALITIES IN
SYMPTOMATIC PEDIATRIC PATIENTS WITH PCR POSITIVE SARS-CoV-2 INFECTION
INCLUDING DRUG INDUCED CHANGES IN THE CORRECTED QT INTERVAL (QTc).
Running Title: CARDIAC ELECTROPHYSIOLOGIC FINDINGS ASSOCIATED WITH PEDIATRIC
Sharmeen Samuel MD, 1,2 Richard A Friedman MD, 1,2 Chetan Sharma MD, 1,2 Madhusudan Ganigara
MD, 1,2 Elizabeth Mitchell MD, 1Charles Schleien MD, 1,2 Andrew D Blaufox, MD.
Affiliation of authors
Section of Pediatric Cardiology
Departments of Pediatrics
Cohen Children’s Medical Center, Northwell Health System
Donald and Barbara Zucker School of Medicine at Hofstra University
Address of correspondence
Sharmeen Samuel, MD.
Division of Pediatric Cardiology
1111 Marcus Ave, 4B
New Hyde Park, NY 11042
Fax no: (516) 601-7380
Email address: email@example.com
CONFLICTS OF INTEREST: None
WORD COUNT: 4913
Background: There is limited data regarding the electrophysiological abnormalities and arrhythmias in
children with COVID-19, including those associated with treatment using potentially pro-arrhythmic
Hydroxychloroquine (HCQ) and Azithromycin (AZN).
Objectives: To describe the electrophysiologic findings and arrhythmias associated with pediatric
COVID-19 and its treatment.
Methods: A single center retrospective chart review was undertaken and included all patients with 1)
symptoms of COVID-19, and 2) PCR (+) nasopharyngeal swabs for SARS-CoV-2 who were placed on
continuous telemetry for the duration of their hospitalization during March through May, 2020.
Results: Thirty-six patients were included in the study. Significant arrhythmias were found in 6 (nonsustained (ns) ventricular tachycardia in 5 and sustained atrial tachycardia in 1). All were self-resolving
and half prompted prophylactic anti-arrhythmic therapy. Patients..
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