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0 0.5 1 1.5 2+ Mortality -200% Improvement Relative Risk ICU admission 67% Hospitalization time 10% HCQ for COVID-19  Uyaroğlu et al.  LATE TREATMENT Is late treatment with HCQ beneficial for COVID-19? PSM retrospective 84 patients in Turkey (March - September 2020) Study compares with favipiravir, results vs. placebo may differ Study underpowered for serious outcomes Uyaroğlu et al., Acta Medica, March 2022 Favors HCQ Favors favipiravir

Comparison of Favipiravir to Hydroxychloroquine Plus Azithromycin in the Treatment of Patients with Non-critical COVID-19: A Single-center, Retrospective, Propensity Score-matched Study

Uyaroğlu et al., Acta Medica, doi:10.32552/2022.ActaMedica.719
Mar 2022  
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PSM retrospective 260 late stage hospitalized COVID-19 pneumonia patients in Turkey, showing no significant difference between favipiravir and HCQ.
This study includes HCQ and favipiravir.
risk of death, 200.0% higher, RR 3.00, p = 1.00, treatment 1 of 42 (2.4%), control 0 of 42 (0.0%), continuity correction due to zero event (with reciprocal of the contrasting arm).
risk of ICU admission, 66.7% lower, RR 0.33, p = 1.00, treatment 0 of 42 (0.0%), control 1 of 42 (2.4%), NNT 42, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
hospitalization time, 9.8% lower, relative time 0.90, p = 0.90, treatment 42, control 42.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Uyaroğlu et al., 17 Mar 2022, retrospective, propensity score matching, Turkey, peer-reviewed, 6 authors, study period 20 March, 2020 - 30 September, 2020, this trial compares with another treatment - results may be better when compared to placebo.
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Comparison of Favipiravir to Hydroxychloroquine Plus Azithromycin in the Treatment of Patients with Non-critical COVID-19: A Singlecenter, Retrospective, Propensity Score-matched Study
Oğuz Abdullah Uyaroğlu
In this study, we compared the clinical outcomes and effects of the treatments on laboratory parameters between patients who were treated with favipiravir (FAV) or hydroxychloroquine plus azithromycin (HCQ/AZ) for COVID-19 pneumonia in non-Intensive Care Unit (non-ICU) patients. Methods: We collected data of 260 moderate or severe COVID-19 patients hospitalized in COVID-19 wards between March 20, 2020, and September 30, 2020 retrospectively. We used propensity score matching to evaluate treatment effect on laboratory parameters of COVID-19 infection. Results: We compared 42 patients using FAV and 42 HCQ/AZ after propensity score matching. While there were statistical differences between the therapy groups in terms of transfer to ICU and/or exitus before matching (p=0.031), this was not significant after propensity analysis (p=0.250). Patients treated with FAV stayed in the hospital nearly one more day than HCQ/AZ group but the difference was not statistically significant (9.02 days vs 8.14 days, p=0.903). The levels of AST,ALT, and LDH increased at discharge in both groups, especially in the FAV group. Conclusions: FAV is not superior to HCQ/AZ in the treatment of COVID-19 infection in hospitalized patients with pneumonia.
Author contribution Study conception and design: ÖU, OAU, and NÇB; data collection: OAU, MÇS, and GTD; analysis and interpretation of results: OAU, MÇS, GTD, NÇB, SK, ÖU; draft manuscript preparation OAU, and ÖU. All authors reviewed the results and approved the final version of the manuscript. Ethical approval The study was approved by the Hacettepe University Non-interventional Clinical Research Ethics Board (Protocol no. GO 20/353/31/03/2020). Funding The authors declare that the study received no funding. Conflict of interest The authors declare that there is no conflict of interest.
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Late treatment
is less effective
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