High in-hospital mortality due to COVID-19 in a community hospital in Spain: a prospective observational study
Trullàs et al.,
High in-hospital mortality due to COVID-19 in a community hospital in Spain: a prospective observational study,
Research Square, doi:10.21203/rs.3.rs-39421/v1 (Preprint)
Retrospective 100 hospitalized patients in Spain showing lower mortality with HCQ+AZ.
risk of death, 35.6% lower, RR 0.64, p = 0.12, treatment 20 of 66 (30.3%), control 16 of 34 (47.1%), NNT 6.0.
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Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
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Trullàs et al., 14 Jul 2020, retrospective, Spain, preprint, median age 75.0, 8 authors, average treatment delay 9.0 days.
Abstract: High in-hospital mortality due to COVID-19 in a
community hospital in Spain: a prospective
observational study
Joan Carles Trullàs ( jctv5153@comg.cat )
Hospital d'Olot https://orcid.org/0000-0002-7380-3475
Eva Ruiz
Hospital de Olot
Clara Weisweiler
Universitat de Girona
Gemma Badosa
Hospital de Olot
Alba Serra
Hospital de Olot
Hugo Briceño
Hospital de Olot
Sílvia Soler
Hospital de Olot
Josep Bisbe
Hospital de Olot
Research article
Keywords: COVID-19, SARS virus, severe acute respiratory syndrome, coronavirus, community hospital,
hospital mortality
Posted Date: July 14th, 2020
DOI: https://doi.org/10.21203/rs.3.rs-39421/v1
License: This work is licensed under a Creative Commons Attribution 4.0 International License.
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Abstract
Background To describe the clinical characteristics and outcome of patients with COVID-19 in a
community hospital in Spain
Methods Prospective, single-centre case series of the first 100 consecutive hospitalized patients with
COVID-19 at a community hospital in Spain, from March 16 to April 20, 2020. Demographics,
comorbidities, clinical presentation, radiologic and laboratory findings, treatment and clinical outcome
were collected.
Results Of the 100 patients included in the study, the median age (IQR; range) was 75 years (20; 28–96)
and 52% were men. The most common comorbidities were hypertension (63%), diabetes (22%) and
cardiovascular diseases (28%). The most common symptoms were fever (80%), cough (69%), fatigue
(59%) and dyspnea (52%) and 64% had respiratory insufficiency. Bilateral interstitial infiltrates (65/100,
65%) and bilateral vertical “B-kerley” lines (38/46, 82.6%) were the most common imaging manifestations
in chest radiographs and lung ultrasound, respectively. All patients received supplementary oxygen, 69
(69%) received medical treatment (the most common regimen being hydroxychloroquine plus
azithromycin in 66 patients) and 12% were treated with glucocorticoids. During hospitalization, 26
patients (26%) died, 10 (10%) were transferred to ICU and 64 (64%) were discharged at home. Mortality or
ICU admission was more frequent in advanced age and with comorbidities.
Conclusions This case series provides clinical characteristics and outcome of consecutively hospitalized
patients with COVID-19 admitted to a community hospital in Spain. The majority were old patients, with
comorbidities and in-hospital mortality was high (26%).
Background
A cluster of pneumonia of unknown origin was identified in Wuhan, China, in December 2019. The
disease named coronavirus disease 2019 (COVID-19) was caused by a novel coronavirus termed SARSCoV-2 and was declared an international public health emergency by the World Health Organization
(WHO). In the WHO European Region, COVID-19 surveillance was implemented on January 2020 and nine
European countries reported 47 cases, being France and Germany the countries with more confirmed
cases. At that time only two cases from Spain were reported [1]. Since then, larger series of cases from
different countries (China, United States and Italy) and different settings (from long-term care facilities to
ICU) have been reported with some differences in demographics, comorbidities and mortality rates [2–4].
In this study, we describe the clinical features and outcome of the first 100 sequentially admitted patients
with laboratory-confirmed COVID-19 to the Hospital de Olot i comarcal de la Garrotxa (HOCG), a
community hospital in..
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