Analgesics
Antiandrogens
Azvudine
Bromhexine
Budesonide
Colchicine
Conv. Plasma
Curcumin
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Ivermectin
Lifestyle
Melatonin
Metformin
Minerals
Molnupiravir
Monoclonals
Naso/orophar..
Nigella Sativa
Nitazoxanide
Paxlovid
Quercetin
Remdesivir
Thermotherapy
Vitamins
More

Other
Feedback
Home
Top
Results
Abstract
All HCQ studies
Meta analysis
 
Feedback
Home
next
study
previous
study
c19hcq.org COVID-19 treatment researchHCQHCQ (more..)
Melatonin Meta
Metformin Meta
Azvudine Meta
Bromhexine Meta Molnupiravir Meta
Budesonide Meta
Colchicine Meta
Conv. Plasma Meta Nigella Sativa Meta
Curcumin Meta Nitazoxanide Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   Meta Analysis    Recent:   

Effet d’un traitement par hydroxychloroquine prescrit comme traitement de fond de rhumatismes inflammatoires chroniques ou maladies auto-immunes systémiques sur les tests diagnostiques et l’évolution de l’infection à SARS CoV-2: étude de 871 patients

Trefond et al., Revue du Rhumatisme, doi:10.1016/j.rhum.2021.09.004 (date from preprint)
Jan 2021  
  Post
  Facebook
Share
  Source   PDF   All Studies   Meta AnalysisMeta
Mortality -17% Improvement Relative Risk Death/ICU -78% Hospitalization -45% HCQ for COVID-19  Trefond et al.  Prophylaxis Is pre-exposure prophylaxis with HCQ beneficial for COVID-19? Retrospective 262 patients in France Higher death/ICU (p=0.21) and hospitalization (p=0.12), not sig. c19hcq.org Trefond et al., Revue du Rhumatisme, Jan 2021 FavorsHCQ Favorscontrol 0 0.5 1 1.5 2+
HCQ for COVID-19
1st treatment shown to reduce risk in March 2020
 
*, now with p < 0.00000000001 from 411 studies, recognized in 46 countries.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,300+ studies for 75 treatments. c19hcq.org
Retrospective 71 chronic HCQ patients compared with 191 matched controls, analyzing only those with a highly suspected or confirmed diagnosis of COVID-19. No significant difference was found in outcomes, however matching failed with extreme confounding - 77.5% of HCQ patients with systemic autoimmune diseases vs. 21.5% of control patients.
Other research shows that the risk of COVID-19 for systemic autoimmune disease patients is much higher overall, Ferri et al. show OR 4.42, p<0.0011.
This study is excluded in the after exclusion results of meta analysis: not fully adjusting for the different baseline risk of systemic autoimmune patients; significant unadjusted confounding possible; excessive unadjusted differences between groups.
risk of death, 16.6% higher, RR 1.17, p = 0.80, treatment 4 of 68 (5.9%), control 12 of 183 (6.6%), adjusted per study, odds ratio converted to relative risk.
risk of death/ICU, 78.2% higher, RR 1.78, p = 0.21, treatment 8 of 71 (11.3%), control 18 of 191 (9.4%), adjusted per study, odds ratio converted to relative risk.
risk of hospitalization, 44.9% higher, RR 1.45, p = 0.12, treatment 24 of 71 (33.8%), control 53 of 191 (27.7%), adjusted per study, odds ratio converted to relative risk.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Trefond et al., 27 Jan 2021, retrospective, France, peer-reviewed, 21 authors.
This PaperHCQAll
Effet d’un traitement par hydroxychloroquine prescrit comme traitement de fond de rhumatismes inflammatoires chroniques ou maladies auto-immunes systémiques sur les tests diagnostiques et l’évolution de l’infection à SARS CoV-2 : étude de 871 patients
Ludovic Trefond, Elodie Drumez, Marc Andre, Nathalie Costedoat-Chalumeau, Raphaèle Seror, Mathilde Devaux, Emmanuelle Dernis, Yannick Dieudonne, Soumaya El Mahou, Aurelia Lanteri, Isabelle Melki, Viviane Queyrel, Mathilde Roumier, Jean Schmidt, Thomas Barnetche, Thierry Thomas, Patrice Cacoub, Alexandre Belot, Olivier Aumaitre, Christophe Richez, Eric Hachulla
Revue du Rhumatisme, doi:10.1016/j.rhum.2021.09.004
Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre -including this research content -immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Nous remercions Elodie Drumez, Julien Labreuche (biostatisticien, CHU-Lille), et Thomas Barnetche (chef de projet, CHU-Bordeaux), pour l'analyse statistique et pour l'aide à la préparation de ce manuscrit. Nick Barton a aidé à la préparation de ce manuscrit, conformément aux Good Publication Practice (GPP3) guidelines. J o u r n a l P r e -p r o o f
References
Cohen, Hydroxychloroquine for the Prevention of Covid-19 -Searching for Evidence, N Engl J Med
Contributors, Sofremip/, CRI/IMIDIATE consortium and. Severity of COVID-19 and survival in patients with rheumatic and inflammatory diseases: data from the French RMD COVID-19 cohort of 694 patients, Ann Rheum Dis
Gautret, Lagier, Parola, Hoang, Meddeb et al., Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an openlabel non-randomized clinical trial, Int J Antimicrob Agents
Geleris, Sun, Platt, Zucker, Baldwin et al., Observational Study of Hydroxychloroquine in Hospitalized Patients with Covid-19, N Engl J Med
Jallouli, Francès, Piette, Huong, Moguelet et al., Hydroxychloroquine-induced pigmentation in patients with systemic lupus erythematosus: a case-control study, JAMA Dermatol
Schrezenmeier, Dörner, Mechanisms of action of hydroxychloroquine and chloroquine: implications for rheumatology, Nat Rev Rheumatol
Skipper, Pastick, Engen, Bangdiwala, Abassi et al., Hydroxychloroquine in Nonhospitalized Adults With Early COVID-19 : A Randomized Trial, Ann Intern Med
Wang, Cao, Zhang, Yang, Liu et al., Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro, Cell Res
Williamson, Walker, Bhaskaran, Bacon, Bates et al., Factors associated with COVID-19-related death using OpenSAFELY, Nature
Yao, Ye, Zhang, Cui, Huang et al., In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), Clin Infect Dis Off Publ Infect Dis Soc Am
{ 'indexed': { 'date-parts': [[2022, 11, 22]], 'date-time': '2022-11-22T10:27:23Z', 'timestamp': 1669112843965}, 'reference-count': 10, 'publisher': 'Elsevier BV', 'issue': '2', 'license': [ { 'start': { 'date-parts': [[2022, 3, 1]], 'date-time': '2022-03-01T00:00:00Z', 'timestamp': 1646092800000}, 'content-version': 'tdm', 'delay-in-days': 0, 'URL': 'https://www.elsevier.com/tdm/userlicense/1.0/'}], 'content-domain': { 'domain': ['clinicalkey.fr', 'em-consulte.com', 'elsevier.com', 'sciencedirect.com'], 'crossmark-restriction': True}, 'published-print': {'date-parts': [[2022, 3]]}, 'DOI': '10.1016/j.rhum.2021.09.004', 'type': 'journal-article', 'created': {'date-parts': [[2021, 9, 29]], 'date-time': '2021-09-29T09:37:16Z', 'timestamp': 1632908236000}, 'page': '192-195', 'update-policy': 'http://dx.doi.org/10.1016/elsevier_cm_policy', 'source': 'Crossref', 'is-referenced-by-count': 1, 'title': 'Effet d’un traitement par hydroxychloroquine prescrit comme traitement de fond de rhumatismes ' 'inflammatoires chroniques ou maladies auto-immunes systémiques sur les tests diagnostiques et ' 'l’évolution de l’infection à SARS CoV-2\xa0: étude de 871\xa0patients', 'prefix': '10.1016', 'volume': '89', 'author': [ {'given': 'Ludovic', 'family': 'Trefond', 'sequence': 'first', 'affiliation': []}, {'given': 'Elodie', 'family': 'Drumez', 'sequence': 'additional', 'affiliation': []}, {'given': 'Marc', 'family': 'Andre', 'sequence': 'additional', 'affiliation': []}, { 'given': 'Nathalie', 'family': 'Costedoat-Chalumeau', 'sequence': 'additional', 'affiliation': []}, {'given': 'Raphaèle', 'family': 'Seror', 'sequence': 'additional', 'affiliation': []}, {'given': 'Mathilde', 'family': 'Devaux', 'sequence': 'additional', 'affiliation': []}, {'given': 'Emmanuelle', 'family': 'Dernis', 'sequence': 'additional', 'affiliation': []}, {'given': 'Yannick', 'family': 'Dieudonne', 'sequence': 'additional', 'affiliation': []}, {'given': 'Soumaya', 'family': 'El Mahou', 'sequence': 'additional', 'affiliation': []}, {'given': 'Aurelia', 'family': 'Lanteri', 'sequence': 'additional', 'affiliation': []}, {'given': 'Isabelle', 'family': 'Melki', 'sequence': 'additional', 'affiliation': []}, {'given': 'Viviane', 'family': 'Queyrel', 'sequence': 'additional', 'affiliation': []}, {'given': 'Mathilde', 'family': 'Roumier', 'sequence': 'additional', 'affiliation': []}, {'given': 'Jean', 'family': 'Schmidt', 'sequence': 'additional', 'affiliation': []}, {'given': 'Thomas', 'family': 'Barnetche', 'sequence': 'additional', 'affiliation': []}, {'given': 'Thierry', 'family': 'Thomas', 'sequence': 'additional', 'affiliation': []}, {'given': 'Patrice', 'family': 'Cacoub', 'sequence': 'additional', 'affiliation': []}, {'given': 'Alexandre', 'family': 'Belot', 'sequence': 'additional', 'affiliation': []}, {'given': 'Olivier', 'family': 'Aumaitre', 'sequence': 'additional', 'affiliation': []}, {'given': 'Christophe', 'family': 'Richez', 'sequence': 'additional', 'affiliation': []}, {'given': 'Eric', 'family': 'Hachulla', 'sequence': 'additional', 'affiliation': []}], 'member': '78', 'reference': [ { 'key': '10.1016/j.rhum.2021.09.004_bib0055', 'doi-asserted-by': 'crossref', 'first-page': '269', 'DOI': '10.1038/s41422-020-0282-0', 'article-title': 'Remdesivir and chloroquine effectively inhibit the recently emerged ' 'novel coronavirus (2019-nCoV) in vitro', 'volume': '30', 'author': 'Wang', 'year': '2020', 'journal-title': 'Cell Res'}, { 'key': '10.1016/j.rhum.2021.09.004_bib0060', 'doi-asserted-by': 'crossref', 'first-page': '732', 'DOI': '10.1093/cid/ciaa237', 'article-title': 'In Vitro Antiviral Activity and Projection of Optimized Dosing Design ' 'of Hydroxychloroquine for the Treatment of Severe Acute Respiratory ' 'Syndrome Coronavirus 2 (SARS-CoV-2)', 'volume': '71', 'author': 'Yao', 'year': '2020', 'journal-title': 'Clin Infect Dis Off Publ Infect Dis Soc Am'}, { 'key': '10.1016/j.rhum.2021.09.004_bib0065', 'doi-asserted-by': 'crossref', 'first-page': '105949', 'DOI': '10.1016/j.ijantimicag.2020.105949', 'article-title': 'Hydroxychloroquine and azithromycin as a treatment of COVID-19: results ' 'of an open-label non-randomized clinical trial', 'volume': '56', 'author': 'Gautret', 'year': '2020', 'journal-title': 'Int J Antimicrob Agents'}, { 'key': '10.1016/j.rhum.2021.09.004_bib0070', 'doi-asserted-by': 'crossref', 'first-page': '527', 'DOI': '10.1136/annrheumdis-2020-218310', 'article-title': 'Severity of COVID-19\xa0and survival in patients with rheumatic and ' 'inflammatory diseases: data from the French RMD COVID-19\xa0cohort of ' '694\xa0patients', 'volume': '80', 'author': 'Contributors F/SFR/SNFMI/SOFREMIP/CRI/IMIDIATE consortium and.', 'year': '2021', 'journal-title': 'Ann Rheum Dis'}, { 'key': '10.1016/j.rhum.2021.09.004_bib0075', 'doi-asserted-by': 'crossref', 'first-page': '430', 'DOI': '10.1038/s41586-020-2521-4', 'article-title': 'Factors associated with COVID-19-related death using OpenSAFELY', 'volume': '584', 'author': 'Williamson', 'year': '2020', 'journal-title': 'Nature'}, { 'key': '10.1016/j.rhum.2021.09.004_bib0080', 'doi-asserted-by': 'crossref', 'first-page': '935', 'DOI': '10.1001/jamadermatol.2013.709', 'article-title': 'Hydroxychloroquine-induced pigmentation in patients with systemic lupus ' 'erythematosus: a case-control study', 'volume': '149', 'author': 'Jallouli', 'year': '2013', 'journal-title': 'JAMA Dermatol'}, { 'key': '10.1016/j.rhum.2021.09.004_bib0085', 'doi-asserted-by': 'crossref', 'first-page': '155', 'DOI': '10.1038/s41584-020-0372-x', 'article-title': 'Mechanisms of action of hydroxychloroquine and chloroquine: ' 'implications for rheumatology', 'volume': '16', 'author': 'Schrezenmeier', 'year': '2020', 'journal-title': 'Nat Rev Rheumatol'}, { 'key': '10.1016/j.rhum.2021.09.004_bib0090', 'doi-asserted-by': 'crossref', 'first-page': '623', 'DOI': '10.7326/M20-4207', 'article-title': 'Hydroxychloroquine in Nonhospitalized Adults With Early COVID-19: A ' 'Randomized Trial', 'volume': '173', 'author': 'Skipper', 'year': '2020', 'journal-title': 'Ann Intern Med'}, { 'key': '10.1016/j.rhum.2021.09.004_bib0095', 'doi-asserted-by': 'crossref', 'first-page': '2411', 'DOI': '10.1056/NEJMoa2012410', 'article-title': 'Observational Study of Hydroxychloroquine in Hospitalized Patients with ' 'Covid-19', 'volume': '382', 'author': 'Geleris', 'year': '2020', 'journal-title': 'N Engl J Med'}, { 'key': '10.1016/j.rhum.2021.09.004_bib0050', 'doi-asserted-by': 'crossref', 'first-page': '585', 'DOI': '10.1056/NEJMe2020388', 'article-title': 'Hydroxychloroquine for the Prevention of Covid-19 - Searching for ' 'Evidence', 'volume': '383', 'author': 'Cohen', 'year': '2020', 'journal-title': 'N Engl J Med'}], 'container-title': 'Revue du Rhumatisme', 'original-title': [], 'language': 'fr', 'link': [ { 'URL': 'https://api.elsevier.com/content/article/PII:S1169833021002489?httpAccept=text/xml', 'content-type': 'text/xml', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://api.elsevier.com/content/article/PII:S1169833021002489?httpAccept=text/plain', 'content-type': 'text/plain', 'content-version': 'vor', 'intended-application': 'text-mining'}], 'deposited': { 'date-parts': [[2022, 7, 10]], 'date-time': '2022-07-10T05:57:46Z', 'timestamp': 1657432666000}, 'score': 1, 'resource': {'primary': {'URL': 'https://linkinghub.elsevier.com/retrieve/pii/S1169833021002489'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2022, 3]]}, 'references-count': 10, 'journal-issue': {'issue': '2', 'published-print': {'date-parts': [[2022, 3]]}}, 'alternative-id': ['S1169833021002489'], 'URL': 'http://dx.doi.org/10.1016/j.rhum.2021.09.004', 'relation': {}, 'ISSN': ['1169-8330'], 'subject': ['Rheumatology'], 'container-title-short': 'Revue du Rhumatisme', 'published': {'date-parts': [[2022, 3]]}, 'assertion': [ {'value': 'Elsevier', 'name': 'publisher', 'label': 'This article is maintained by'}, { 'value': 'Effet d’un traitement par hydroxychloroquine prescrit comme traitement de fond ' 'de rhumatismes inflammatoires chroniques ou maladies auto-immunes systémiques ' 'sur les tests diagnostiques et l’évolution de l’infection à SARS CoV-2\xa0: ' 'étude de 871\xa0patients', 'name': 'articletitle', 'label': 'Article Title'}, {'value': 'Revue du Rhumatisme', 'name': 'journaltitle', 'label': 'Journal Title'}, { 'value': 'https://doi.org/10.1016/j.rhum.2021.09.004', 'name': 'articlelink', 'label': 'CrossRef DOI link to publisher maintained version'}, { 'value': 'https://doi.org/10.1016/j.jbspin.2021.105226', 'name': 'associatedlink', 'label': 'CrossRef DOI link to the associated document'}, {'value': 'simple-article', 'name': 'content_type', 'label': 'Content Type'}, { 'value': '© 2021 Société Française de Rhumatologie. Published by Elsevier Masson SAS. All ' 'rights reserved.', 'name': 'copyright', 'label': 'Copyright'}]}
Loading..
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit