A retrospective comparison of drugs against COVID-19
Jiahong Tan, Yuan Yuan, Cheng Xu, Chunyan Song, Dan Liu, Ding Ma, Qinglei Gao
Virus Research, doi:10.1016/j.virusres.2020.198262
Coronavirus disease 19 (COVID-19) has posed serious threats to the general population. To relieve the crisis, a comparison of drug effects against COVID-19 is instructive. Between January 27, 2020 and March 21, 2020, a total of 333 patients treated with arbidol, corticosteroids, hydroxychloroquine, lopinavir/ritonavir, or oseltamivir monotherapy, having definite outcomes and serological antibody detection results, were retrospectively analyzed. The hydroxychloroquine group had a significantly reduced duration of hospital stay than the arbidol and corticosteroids groups. The oseltamivir group had a significantly shorter length of hospital stay than the arbidol, corticosteroids, and lopinavir/ritonavir groups. The hydroxychloroquine group had a significantly higher IgM titer than the other four groups and exhibited significantly higher IgG levels than the arbidol, lopinavir/ritonavir, and oseltamivir groups. Our findings indicated that hydroxychloroquine might have the potential for efficient COVID-19 management, while oseltamivir should be prudently considered in combination therapy.
CRediT authorship contribution statement Jiahong Tan: Methodology, Formal analysis, Writing -original draft, Visualization. Yuan Yuan: Methodology, Formal analysis, Writing -original draft, Visualization. Cheng Xu: Formal analysis, Visualization. Chunyan Song: Formal analysis, Visualization. Dan Liu: Formal analysis, Visualization, Funding acquisition. Ding Ma: Conceptualization, Supervision. Qinglei Gao: Conceptualization, Funding acquisition, Writing -review & editing, Supervision.
Declaration of Competing Interest None.
Appendix A. Supplementary data Supplementary material related to this article can be found, in the online version, at doi:https://doi.org/10.1016/j.virusres.2020.198262.
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