Analgesics
Antiandrogens
Antihistamines
Azvudine
Bromhexine
Budesonide
Colchicine
Conv. Plasma
Curcumin
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Ivermectin
Lifestyle
Melatonin
Metformin
Minerals
Molnupiravir
Monoclonals
Naso/orophar..
Nigella Sativa
Nitazoxanide
PPIs
Paxlovid
Quercetin
Remdesivir
Thermotherapy
Vitamins
More

Other
Feedback
Home
 
next
study
previous
study
c19hcq.org COVID-19 treatment researchHCQHCQ (more..)
Melatonin Meta
Metformin Meta
Antihistamines Meta
Azvudine Meta Molnupiravir Meta
Bromhexine Meta
Budesonide Meta
Colchicine Meta Nigella Sativa Meta
Conv. Plasma Meta Nitazoxanide Meta
Curcumin Meta PPIs Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   Meta Analysis       

The Frontline War: A Case-control study of risk factors for COVID-19 among health care workers

Sukumar et al., F1000Research, doi:10.12688/f1000research.109023.1
Nov 2022  
  Post
  Facebook
Share
  Source   PDF   All Studies   Meta AnalysisMeta
Case 38% Improvement Relative Risk HCQ for COVID-19  Sukumar et al.  Prophylaxis Is pre-exposure prophylaxis with HCQ beneficial for COVID-19? Retrospective 116 patients in India (July - September 2020) Fewer cases with HCQ (not stat. sig., p=0.3) c19hcq.org Sukumar et al., F1000Research, November 2022 FavorsHCQ Favorscontrol 0 0.5 1 1.5 2+
HCQ for COVID-19
1st treatment shown to reduce risk in March 2020, now with p < 0.00000000001 from 419 studies, recognized in 46 countries.
No treatment is 100% effective. Protocols combine treatments.
5,100+ studies for 112 treatments. c19hcq.org
Case control study of healthcare workers in India, showing lower risk of cases with HCQ prophylaxis, without statistical significance.
While authors comment negatively, as may be required for publication, and this study alone is not statistically significant, the result is consistent with the positive results in all studies to date. Currently there are 109 HCQ for COVID-19 pre-exposure prophylaxis studies, showing 31% lower mortality [15‑44%] and 29% fewer cases [21‑36%].
risk of case, 37.6% lower, OR 0.62, p = 0.30, treatment 10 of 57 (17.5%) cases, 15 of 59 (25.4%) controls, NNT 8.6, case control OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Sukumar et al., 14 Nov 2022, retrospective, India, peer-reviewed, survey, 5 authors, study period July 2020 - September 2020. Contact: vsagar33@gmail.com.
This PaperHCQAll
The Frontline War: A Case-control study of risk factors for COVID-19 among health care workers
Cynthia Amrutha Sukumar, Nandakrishna Bolanthakodi, Aarthi Venkatramanan, Ravishankar Nagraj, Sudha Vidyasagar
F1000Research, doi:10.12688/f1000research.109023.1
Purpose: The global pandemic of COVID-19 has infected several people worldwide. World Health Organization(WHO) has reported that an alarming number of health care workers (HCWs) have been affected and have also succumbed to this disease. Though health infrastructure can be boosted in a short period, the number of HCWs cannot. Hence understanding the risk factors that the HCWs are exposed to and strategically protecting them is of paramount importance. Methods: A case-control retrospective study was carried out on 116 HCWs at a tertiary care hospital treating COVID-19 patients in South India. We attempted to investigate and stratify the specific risk factors for COVID-19 transmission among HCWs. Data was collected regarding their exposure to COVID-19 patients, infection control precautions used, possible breaches in the protocol, and details of Hydroxychloroquine (HCQ) prophylaxis. Results: The demographics were equally distributed among the cases and controls. Exposure to surgical procedures on suspected/positive COVID patients was also found to affect contracting the COVID-19 illness. HCWs who wore face shields instead of eye goggles along with the use of scrubs and hospital gowns were found to have a lesser incidence of COVID-19 illness. Conclusion: This study helped us understand the varied risk factors that health care workers are exposed to while treating COVID-19 patients. It helped us contextualize and strategize our infection control practices to prevent further morbidity and mortality due to COVID-19.
Author contributions CAS and SV conceptualized the study. NB was involved in drafting the protocol and ethical clearance. AV and RN were involved with the initial planning data collection and data analysis. NB also contributed to the data processing and analysis. CAS, SV and NB were involved in preparing the draft and editing the final manuscript.
References
Blouhos, Boulas, Paraskeva, Understanding surgical risk during COVID-19 pandemic: the rationale behind the decisions, Front. Surg, doi:10.3389/fsurg.2020.00033
Chatterjee, Anand, Singh, Healthcare workers & SARS-CoV-2 infection in India: A case-control investigation in the time of COVID-19, Indian J. Med. Res, doi:10.4103/ijmr.IJMR_2234_20
Chou, Dana, Buckley, Epidemiology of and Risk Factors for Coronavirus Infection in Health Care Workers, Ann. Intern. Med
Deo, Doctor population ratio for India-The reality, Indian J. Med. Res
Dong, Du, Gardner, An interactive web-based dashboard to track COVID-19 in real-time, Lancet Infect. Dis, doi:10.1016/S1473-3099(20)30120-1
El-Boghdadly, Wong, Owen, Risks to healthcare workers following tracheal intubation of patients with COVID-19: a prospective international multicentre cohort study, Anaesthesia
Gbinigie, Frie, Should chloroquine and hydroxychloroquine be used to treat COVID-19? A rapid review, Br. J. Gen. Pract. open, doi:10.3399/bjgpopen20X101069
Jha, Soni, Siddiqui, Prevalence of flu-like symptoms and COVID-19 in healthcare workers from India, J. Assoc. Physicians India
Kucharski, Russell, Diamond, Early dynamics of transmission and control of COVID-19: a mathematical modelling study, Lancet Infect. Dis, doi:10.1016/S1473-3099(20)30144-4
Liu, Cheng, Xu, Use of personal protective equipment against coronavirus disease 2019 by healthcare professionals in Wuhan, China: a cross-sectional study, N. Engl. J. Med, doi:10.1136/bmj.m2195
Owen, Laird, The role of textiles as fomites in the healthcare environment: a review of the infection control risk, Peer J, doi:10.7717/peerj.9790
Park, Personal protective equipment for healthcare workers during the COVID-19 pandemic, J. Infect. Chemother, doi:10.3947/ic.2020.52.2.165
Singh, Ryan, Kredo, Chloroquine or hydroxychloroquine for prevention and treatment of COVID-19, Cochrane Database Syst. Rev, doi:10.1002/14651858.CD013587
Temime, Gustin, Duval, Estimating R0 of SARS-COV-2 in Health care settings, doi:10.1101/2020.04.20.20072462
Van Doremalen, Bushmaker, Morris, Aerosol and surface stability of SARS-CoV-2 as compared with SARS-CoV-1, N. Engl. J. Med
Wang, Xu, Gao, Detection of SARS-CoV-2 in different types of clinical specimens, J. Am. Med. Assoc, doi:10.1001/jama.2020.3786
Çelebi, Pişkin, Bekleviç, Specific risk factors for SARS-CoV-2 transmission among health care workers in a university hospital, Am. J. Infect. Control, doi:10.1016/j.ajic.2020.07.039
{ 'indexed': { 'date-parts': [[2022, 11, 15]], 'date-time': '2022-11-15T06:05:13Z', 'timestamp': 1668492313393}, 'reference-count': 19, 'publisher': 'F1000 Research Ltd', 'license': [ { 'start': { 'date-parts': [[2022, 11, 14]], 'date-time': '2022-11-14T00:00:00Z', 'timestamp': 1668384000000}, 'content-version': 'tdm', 'delay-in-days': 0, 'URL': 'http://creativecommons.org/licenses/by/4.0/'}], 'content-domain': {'domain': ['f1000research.com'], 'crossmark-restriction': False}, 'abstract': '<ns4:p>Purpose:</ns4:p><ns4:p> The global pandemic of COVID-19 has infected several people ' 'worldwide. World Health Organization(WHO) has reported that an alarming number of health care ' 'workers (HCWs) have been affected and have also succumbed to this disease. Though health ' 'infrastructure can be boosted in a short period, the number of HCWs cannot. Hence ' 'understanding the risk factors that the HCWs are exposed to and strategically protecting them ' 'is of paramount importance.</ns4:p><ns4:p> Methods:</ns4:p><ns4:p> A case-control ' 'retrospective study was carried out on 116 HCWs at a tertiary care hospital treating COVID-19 ' 'patients in South India. We attempted to investigate and stratify the specific risk factors ' 'for COVID-19 transmission among HCWs. Data was collected regarding their exposure to COVID-19 ' 'patients, infection control precautions used, possible breaches in the protocol, and details ' 'of Hydroxychloroquine (HCQ) prophylaxis.</ns4:p><ns4:p> Results:</ns4:p><ns4:p> The ' 'demographics were equally distributed among the cases and controls. Exposure to surgical ' 'procedures on suspected/positive COVID patients was also found to affect contracting the ' 'COVID-19 illness. HCWs who wore face shields instead of eye goggles along with the use of ' 'scrubs and hospital gowns were found to have a lesser incidence of COVID-19 ' 'illness.</ns4:p><ns4:p> Conclusion:</ns4:p><ns4:p> This study helped us understand the varied ' 'risk factors that health care workers are exposed to while treating COVID-19 patients. It ' 'helped us contextualize and strategize our infection control practices to prevent further ' 'morbidity and mortality due to COVID-19.</ns4:p>', 'DOI': '10.12688/f1000research.109023.1', 'type': 'journal-article', 'created': { 'date-parts': [[2022, 11, 14]], 'date-time': '2022-11-14T14:30:16Z', 'timestamp': 1668436216000}, 'page': '1298', 'update-policy': 'http://dx.doi.org/10.12688/f1000research.crossmark-policy', 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'The Frontline War: A Case-control study of risk factors for COVID-19 among health care workers', 'prefix': '10.12688', 'volume': '11', 'author': [ { 'ORCID': 'http://orcid.org/0000-0002-7026-2474', 'authenticated-orcid': False, 'given': 'Cynthia Amrutha', 'family': 'Sukumar', 'sequence': 'first', 'affiliation': []}, { 'given': 'Nandakrishna', 'family': 'Bolanthakodi', 'sequence': 'additional', 'affiliation': []}, {'given': 'Aarthi', 'family': 'Venkatramanan', 'sequence': 'additional', 'affiliation': []}, {'given': 'Ravishankar', 'family': 'Nagraj', 'sequence': 'additional', 'affiliation': []}, {'given': 'Sudha', 'family': 'Vidyasagar', 'sequence': 'additional', 'affiliation': []}], 'member': '2560', 'published-online': {'date-parts': [[2022, 11, 14]]}, 'reference': [ { 'key': 'ref1', 'doi-asserted-by': 'publisher', 'first-page': '533-534', 'DOI': '10.1016/S1473-3099(20)30120-1', 'article-title': 'An interactive web-based dashboard to track COVID-19 in real-time.', 'volume': '20', 'author': 'E Dong', 'year': '2020', 'journal-title': 'Lancet Infect. Dis.'}, { 'key': 'ref2', 'first-page': '632-635', 'article-title': 'Doctor population ratio for India-The reality.', 'volume': '137', 'author': 'M Deo', 'year': '2013', 'journal-title': 'Indian J. Med. Res.'}, { 'key': 'ref3', 'doi-asserted-by': 'publisher', 'first-page': '120-136', 'DOI': '10.7326/M20-1632', 'article-title': 'Epidemiology of and Risk Factors for Coronavirus Infection in Health ' 'Care Workers.', 'volume': '173', 'author': 'R Chou', 'year': '2020', 'journal-title': 'Ann. Intern. Med.'}, { 'key': 'ref4', 'first-page': '27-29', 'article-title': 'Prevalence of flu-like symptoms and COVID-19 in healthcare workers from ' 'India.', 'volume': '68', 'author': 'S Jha', 'year': '2020 Jul 1', 'journal-title': 'J. Assoc. Physicians India.'}, { 'key': 'ref5', 'doi-asserted-by': 'publisher', 'first-page': '459', 'DOI': '10.4103/ijmr.IJMR_2234_20', 'article-title': 'Healthcare workers & SARS-CoV-2 infection in India: A case-control ' 'investigation in the time of COVID-19.', 'volume': '151', 'author': 'P Chatterjee', 'year': '2020', 'journal-title': 'Indian J. Med. Res.'}, { 'key': 'ref6', 'doi-asserted-by': 'publisher', 'first-page': '1225-1230', 'DOI': '10.1016/j.ajic.2020.07.039', 'article-title': 'Specific risk factors for SARS-CoV-2 transmission among health care ' 'workers in a university hospital.', 'volume': '48', 'author': 'G Çelebi', 'year': '2020', 'journal-title': 'Am. J. Infect. Control.'}, { 'key': 'ref7', 'doi-asserted-by': 'publisher', 'article-title': 'Estimating R0 of SARS-COV-2 in Health care settings.', 'author': 'L Temime', 'year': '2020', 'journal-title': 'medRxiv.', 'DOI': '10.1101/2020.04.20.20072462'}, { 'key': 'ref8', 'doi-asserted-by': 'publisher', 'first-page': '1564-1567', 'DOI': '10.1056/NEJMc2004973', 'article-title': 'Aerosol and surface stability of SARS-CoV-2 as compared with ' 'SARS-CoV-1.', 'volume': '382', 'author': 'N Van Doremalen', 'year': '2020', 'journal-title': 'N. Engl. J. Med.'}, { 'key': 'ref9', 'doi-asserted-by': 'publisher', 'first-page': '1437-1447', 'DOI': '10.1111/anae.15170', 'article-title': 'Risks to healthcare workers following tracheal intubation of patients ' 'with COVID-19: a prospective international multicentre cohort study.', 'volume': '75', 'author': 'K El-Boghdadly', 'year': '2020', 'journal-title': 'Anaesthesia.'}, { 'key': 'ref10', 'doi-asserted-by': 'publisher', 'first-page': '369', 'DOI': '10.1136/bmj.m2195', 'article-title': 'Use of personal protective equipment against coronavirus disease 2019 ' 'by healthcare professionals in Wuhan, China: a cross-sectional study.', 'volume': '10', 'author': 'M Liu', 'year': '2020', 'journal-title': 'Brit. Med. J.'}, { 'key': 'ref11', 'doi-asserted-by': 'publisher', 'first-page': '1177-1179', 'DOI': '10.1056/NEJMc2001737', 'article-title': 'SARS-CoV-2 Viral Load in Upper Respiratory Specimens of Infected ' 'Patients.', 'volume': '382', 'author': 'L Zou', 'year': '2020', 'journal-title': 'N. Engl. J. Med.'}, { 'key': 'ref12', 'doi-asserted-by': 'publisher', 'first-page': '1843-1844', 'DOI': '10.1001/jama.2020.3786', 'article-title': 'Detection of SARS-CoV-2 in different types of clinical specimens.', 'volume': '323', 'author': 'W Wang', 'year': '2020', 'journal-title': 'J. Am. Med. Assoc.'}, { 'key': 'ref13', 'doi-asserted-by': 'publisher', 'first-page': '33', 'DOI': '10.3389/fsurg.2020.00033', 'article-title': 'Understanding surgical risk during COVID-19 pandemic: the rationale ' 'behind the decisions.', 'volume': '7', 'author': 'K Blouhos', 'year': '2020', 'journal-title': 'Front. Surg.'}, { 'key': 'ref14', 'article-title': 'Infection prevention and control during health care when novel ' 'coronavirus (nCoV) infection is suspected: interim guidance.', 'year': '2020'}, { 'key': 'ref15', 'doi-asserted-by': 'publisher', 'first-page': '165-182', 'DOI': '10.3947/ic.2020.52.2.165', 'article-title': 'Personal protective equipment for healthcare workers during the ' 'COVID-19 pandemic.', 'volume': '52', 'author': 'S Park', 'year': '2020', 'journal-title': 'J. Infect. Chemother.'}, { 'key': 'ref16', 'doi-asserted-by': 'publisher', 'first-page': 'e9790', 'DOI': '10.7717/peerj.9790', 'article-title': 'The role of textiles as fomites in the healthcare environment: a review ' 'of the infection control risk.', 'volume': '8', 'author': 'L Owen', 'year': '2020', 'journal-title': 'Peer J.'}, { 'key': 'ref17', 'doi-asserted-by': 'publisher', 'article-title': 'Chloroquine or hydroxychloroquine for prevention and treatment of ' 'COVID-19.', 'author': 'B Singh', 'year': '2021', 'journal-title': 'Cochrane Database Syst. Rev.', 'DOI': '10.1002/14651858.CD013587'}, { 'key': 'ref18', 'doi-asserted-by': 'publisher', 'first-page': '553-558', 'DOI': '10.1016/S1473-3099(20)30144-4', 'article-title': 'Early dynamics of transmission and control of COVID-19: a mathematical ' 'modelling study.', 'volume': '20', 'author': 'A Kucharski', 'year': '2020', 'journal-title': 'Lancet Infect. Dis.'}, { 'key': 'ref19', 'doi-asserted-by': 'publisher', 'first-page': '20', 'DOI': '10.3399/bjgpopen20X101069', 'article-title': 'Should chloroquine and hydroxychloroquine be used to treat COVID-19? A ' 'rapid review.', 'volume': '4', 'author': 'K Gbinigie', 'year': '2020', 'journal-title': 'Br. J. Gen. Pract. open.'}], 'container-title': 'F1000Research', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://f1000research.com/articles/11-1298/v1/xml', 'content-type': 'application/xml', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://f1000research.com/articles/11-1298/v1/pdf', 'content-type': 'application/pdf', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://f1000research.com/articles/11-1298/v1/iparadigms', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2022, 11, 14]], 'date-time': '2022-11-14T14:30:28Z', 'timestamp': 1668436228000}, 'score': 1, 'resource': {'primary': {'URL': 'https://f1000research.com/articles/11-1298/v1'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2022, 11, 14]]}, 'references-count': 19, 'URL': 'http://dx.doi.org/10.12688/f1000research.109023.1', 'relation': {}, 'ISSN': ['2046-1402'], 'subject': [ 'General Pharmacology, Toxicology and Pharmaceutics', 'General Immunology and Microbiology', 'General Biochemistry, Genetics and Molecular Biology', 'General Medicine'], 'container-title-short': 'F1000Res', 'published': {'date-parts': [[2022, 11, 14]]}, 'assertion': [ { 'value': 'Awaiting Peer Review', 'URL': 'https://f1000research.com/articles/11-1298/v1#article-reports', 'order': 0, 'name': 'referee-status', 'label': 'Referee status', 'group': {'name': 'current-referee-status', 'label': 'Current Referee Status'}}, { 'value': 'The author(s) declared that no grants were involved in supporting this work', 'order': 0, 'name': 'grant-information', 'label': 'Grant Information'}, { 'value': 'This is an open access article distributed under the terms of the Creative ' 'Commons Attribution Licence, which permits unrestricted use, distribution, and ' 'reproduction in any medium, provided the original work is properly cited.', 'order': 0, 'name': 'copyright-info', 'label': 'Copyright'}]}
Loading..
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit