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0 0.5 1 1.5 2+ Case 38% Improvement Relative Risk c19hcq.org Sukumar et al. HCQ for COVID-19 PrEP Is pre-exposure prophylaxis with HCQ beneficial for COVID-19? Retrospective 116 patients in India (July - September 2020) Fewer cases with HCQ (not stat. sig., p=0.3) Sukumar et al., F1000Research, doi:10.12688/f1000research.109023.1 Favors HCQ Favors control
The Frontline War: A Case-control study of risk factors for COVID-19 among health care workers
Sukumar et al., F1000Research, doi:10.12688/f1000research.109023.1
Sukumar et al., The Frontline War: A Case-control study of risk factors for COVID-19 among health care workers, F1000Research, doi:10.12688/f1000research.109023.1
Nov 2022   Source   PDF  
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Case control study of healthcare workers in India, showing lower risk of cases with HCQ prophylaxis, without statistical significance.
While authors comment negatively, as may be required for publication, and this study alone is not statistically significant, the result is consistent with the positive results in all studies to date. Currently there are 90 HCQ for COVID-19 pre-exposure prophylaxis studies, showing 30% lower mortality [11‑45%] and 31% fewer cases [22‑38%].
risk of case, 37.6% lower, OR 0.62, p = 0.30, treatment 10 of 57 (17.5%) cases, 15 of 59 (25.4%) controls, NNT 8.6, case control OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Sukumar et al., 14 Nov 2022, retrospective, India, peer-reviewed, survey, 5 authors, study period July 2020 - September 2020.
Contact: vsagar33@gmail.com.
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Abstract: F1000Research 2022, 11:1298 Last updated: 14 NOV 2022 RESEARCH ARTICLE The Frontline War: A Case-control study of risk factors for COVID-19 among health care workers [version 1; peer review: awaiting peer review] Cynthia Amrutha Sukumar 1, Nandakrishna Bolanthakodi1, Aarthi Venkatramanan1, Ravishankar Nagraj2, Sudha Vidyasagar1 1Department of Medicine, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India 2Department of Biostatistics, Vallabhbhai Institute of Chest medicine, New Delhi, India v1 First published: 14 Nov 2022, 11:1298 https://doi.org/10.12688/f1000research.109023.1 Latest published: 14 Nov 2022, 11:1298 https://doi.org/10.12688/f1000research.109023.1 Open Peer Review Approval Status AWAITING PEER REVIEW Any reports and responses or comments on the Abstract Purpose: The global pandemic of COVID-19 has infected several people worldwide. World Health Organization(WHO) has reported that an alarming number of health care workers (HCWs) have been affected and have also succumbed to this disease. Though health infrastructure can be boosted in a short period, the number of HCWs cannot. Hence understanding the risk factors that the HCWs are exposed to and strategically protecting them is of paramount importance. Methods: A case-control retrospective study was carried out on 116 HCWs at a tertiary care hospital treating COVID-19 patients in South India. We attempted to investigate and stratify the specific risk factors for COVID-19 transmission among HCWs. Data was collected regarding their exposure to COVID-19 patients, infection control precautions used, possible breaches in the protocol, and details of Hydroxychloroquine (HCQ) prophylaxis. Results: The demographics were equally distributed among the cases and controls. Exposure to surgical procedures on suspected/positive COVID patients was also found to affect contracting the COVID-19 illness. HCWs who wore face shields instead of eye goggles along with the use of scrubs and hospital gowns were found to have a lesser incidence of COVID-19 illness. Conclusion: This study helped us understand the varied risk factors that health care workers are exposed to while treating COVID-19 patients. It helped us contextualize and strategize our infection control practices to prevent further morbidity and mortality due to COVID-19. article can be found at the end of the article. Page 1 of 11 F1000Research 2022, 11:1298 Last updated: 14 NOV 2022 Keywords COVID-19, SARS-CoV-2, Infection control, prevention, health care workers, coronavirus, risk factors This article is included in the Manipal Academy of Higher Education gateway. This article is included in the Emerging Diseases and Outbreaks gateway. This article is included in the Coronavirus collection. Corresponding author: Sudha Vidyasagar (vsagar33@gmail.com) Author roles: Sukumar CA: Conceptualization, Data Curation, Formal Analysis, Investigation, Methodology, Resources, Software, Supervision, Validation, Visualization, Writing – Original Draft Preparation, Writing – Review & Editing; Bolanthakodi N: Conceptualization, Data Curation, Formal Analysis, Investigation, Methodology, Writing – Original Draft Preparation, Writing – Review & Editing; Venkatramanan A: Data Curation, Formal Analysis, Investigation, Methodology, Resources, Software, Validation, Visualization; Nagraj R: Conceptualization, Data Curation, Formal Analysis, Investigation, Methodology, Resources, Software,..
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