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All Studies   Meta Analysis    Recent:   
0 0.5 1 1.5 2+ Mortality 27% Improvement Relative Risk Mortality (b) 93% HCQ for COVID-19  Smith et al.  LATE TREATMENT Is late treatment with HCQ beneficial for COVID-19? Retrospective 255 patients in the USA Lower mortality with HCQ (p=0.0024) c19hcq.org Smith et al., medRxiv, May 2021 Favors HCQ Favors control

Observational Study on 255 Mechanically Ventilated Covid Patients at the Beginning of the USA Pandemic

Smith et al., medRxiv, doi:10.1101/2021.05.28.21258012
May 2021  
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HCQ for COVID-19
1st treatment shown to reduce risk in March 2020
 
*, now known with p < 0.00000000001 from 421 studies, recognized in 42 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
3,800+ studies for 60+ treatments. c19hcq.org
Retrospective 255 mechanical ventilation patients in USA, showing that weight-adjusted HCQ+AZ improved survival by over 100%. QTc prolongation did not correlate with cumulative HCQ dose or HCQ serum level.
Although authors mention immortal time bias, full details on the timing of HCQ administration is not provided and this is not fully addressed. Survival curves indicate immortal time bias will significantly change results, although the observed benefit appears to exceed the potential bias.
This study is excluded in the after exclusion results of meta analysis: immortal time bias may significantly affect results.
risk of death, 27.2% lower, RR 0.73, p = 0.002, treatment 19 of 37 (51.4%), control 182 of 218 (83.5%), NNT 3.1, odds ratio converted to relative risk, >3g HCQ and >1g AZ, multivariable cox proportional hazard regression.
risk of death, 92.9% lower, OR 0.07, p < 0.001, inverted to make OR<1 favor treatment, ≥80mg/kg HCQ and >1g AZ, RR approximated with OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Smith et al., 31 May 2021, retrospective, USA, preprint, 4 authors.
This PaperHCQAll
Observational Study on 255 Mechanically Ventilated Covid Patients at the Beginning of the USA Pandemic
Leon G Smith, Nicolas Mendoza, David Dobesh, Stephen M Smith
doi:10.1101/2021.05.28.21258012
All rights reserved. No reuse allowed without permission. (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
References
Arentz, Yim, Klaff, Lokhandwala, Riedo et al., Characteristics and Outcomes of 21 Critically Ill Patients With COVID-19 in Washington State, JAMA
Association, Diagnosis and Classification of Diabetes Mellitus, Diabetes Care
Bhatraju, Ghassemieh, Nichols, Kim, Jerome et al., Covid-19 in Critically Ill Patients in the Seattle Region -Case Series, N Engl J Med
Borges Do Nascimento, Groote, Mathúna, Abdulazeem, Henderson et al., Clinical, laboratory and radiological characteristics and outcomes of novel coronavirus (SARS-CoV-2) infection in humans: A systematic review and series of metaanalyses, PloS One
Casadevall, Grossman, Henderson, Joyner, Shoham et al., The Assessment of Convalescent Plasma Efficacy against COVID-19, Med N Y N
Chorin, Dai, Shulman, Wadhwani, Cohen et al., The QT Interval in Patients with SARS-CoV-2 Infection Treated with Hydroxychloroquine/Azithromycin [Internet, Cardiovascular Medicine, doi:10.1101/2020.04.02.20047050
Colson, Rolain, Lagier, Brouqui, Raoult, Chloroquine and hydroxychloroquine as available weapons to fight COVID-19, Int J Antimicrob Agents
Costedoat-Chalumeau, Galicier, Aumaître, Francès, Guern et al., Hydroxychloroquine in systemic lupus erythematosus: results of a French multicentre controlled trial (PLUS Study), Ann Rheum Dis
Cummings, Baldwin, Abrams, Jacobson, Meyer et al., Epidemiology, clinical course, and outcomes of critically ill adults with COVID-19 in New York City: a prospective cohort study, The Lancet
Fadel, Morrison, Vahia, Smith, Chaudhry et al., Early Short-Course Corticosteroids in Hospitalized Patients With COVID-19, Clin Infect Dis Off Publ Infect Dis Soc Am
Figliozzi, Masci, Ahmadi, Tondi, Koutli et al., Predictors of adverse prognosis in COVID-19: A systematic review and meta-analysis, Eur J Clin Invest
Furst, Lindsley, Baethge, Botstein, Caldwell et al., Dose-loading with hydroxychloroquine improves the rate of response in early, active rheumatoid arthritis: A randomized, double-blind six-week trial with eighteen-week extension, Arthritis Rheum
Furtado, Berwanger, Fonseca, Corrêa, Ferraz et al., Azithromycin in addition to standard of care versus standard of care alone in the treatment of patients admitted to the hospital with severe COVID-19 in Brazil (COALITION II): a randomised clinical trial, The Lancet
Gautret, Lagier, Parola, Hoang, Meddeb et al., Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial, Int J Antimicrob Agents
Geleris, Sun, Platt, Zucker, Baldwin et al., Observational Study of Hydroxychloroquine in Hospitalized Patients with Covid-19, N Engl J Med
Grasselli, Pesenti, Cecconi, Critical Care Utilization for the COVID-19 Outbreak in Lombardy, Italy: Early Experience and Forecast During an Emergency Response, JAMA
Harris, Tambyah, Lye, Mo, Lee et al., Effect of Piperacillin-Tazobactam vs Meropenem on 30-Day Mortality for Patients With E coli or Klebsiella pneumoniae Bloodstream Infection and Ceftriaxone Resistance: A Randomized Clinical Trial, JAMA
Ip, Ahn, Zhou, Goy, Hansen et al., Hydroxychloroquine in the treatment of outpatients with mildly symptomatic COVID-19: a multi-center observational study, BMC Infect Dis
Isbister, Friberg, Duffull, Application of pharmacokineticpharmacodynamic modelling in management of QT abnormalities after citalopram overdose, Intensive Care Med
Izcovich, Ragusa, Tortosa, Marzio, Agnoletti et al., Prognostic factors for severity and mortality in patients infected with COVID-19: A systematic review, PloS One
King, Sahjwani, Brown, Feroz, Cameron et al., Outcomes of mechanically ventilated patients with COVID-19 associated respiratory failure, PloS One
Lauriola, Pani, Ippoliti, Mortara, Milighetti et al., Effect of Combination Therapy of Hydroxychloroquine and Azithromycin on Mortality in Patients With COVID-19, Clin Transl Sci
Li, He, Yuan Yuan Null, Zhang, Li et al., Meta-analysis investigating the relationship between clinical features, outcomes, and severity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia, Am J Infect Control
Mahumud, Kamara, Renzaho, The epidemiological burden and overall distribution of chronic comorbidities in coronavirus disease-2019 among 202,005 infected patients: evidence from a systematic review and meta-analysis, Infection
Mercuro, Yen, Shim, Maher, Mccoy et al., Risk of QT Interval Prolongation Associated With Use of Hydroxychloroquine With or Without Concomitant Azithromycin Among Hospitalized Patients Testing Positive for Coronavirus Disease 2019 (COVID-19), JAMA Cardiol
Mesas, Cavero-Redondo, Álvarez-Bueno, Cabrera, De Andrade et al., Predictors of in-hospital COVID-19 mortality: A comprehensive systematic review and metaanalysis exploring differences by age, sex and health conditions, PloS One
Mikami, Miyashita, Yamada, Harrington, Steinberg et al., Risk Factors for Mortality in Patients with COVID-19 in New York City, J Gen Intern Med
Moghissi, Korytkowski, Dinardo, Einhorn, Hellman et al., American Association of Clinical Endocrinologists and American Diabetes Association Consensus Statement on Inpatient Glycemic Control, Diabetes Care
Munster, Gibbs, Shen, Baethge, Botstein et al., Hydroxychloroquine concentration-response relationships in patients with rheumatoid arthritis, Arthritis Rheum
Nandy, Salunke, Pathak, Pandey, Doctor et al., Coronavirus disease (COVID-19): A systematic review and meta-analysis to evaluate the impact of various comorbidities on serious events, Diabetes Metab Syndr
Naymagon, Zubizarreta, Feld, Van Gerwen, Alsen et al., Admission D-dimer levels, D-dimer trends, and outcomes in COVID-19, Thromb Res
O'connell, Bradley, Abbas, Williamson, Rusia et al., Hydroxychloroquine/Azithromycin Therapy and QT Prolongation in Hospitalized Patients With COVID-19, Jacc Clin Electrophysiol
Papoutsi, Giannakoulis, Xourgia, Routsi, Kotanidou et al., Effect of timing of intubation on clinical outcomes of critically ill patients with COVID-19: a systematic review and meta-analysis of nonrandomized cohort studies, Crit Care Lond Engl
Petrilli, Jones, Yang, Rajagopalan, Donnell et al., Factors associated with hospitalization and critical illness among 4,103 patients with COVID-19 disease in
Ranzani, Bastos, Gelli, Marchesi, Baião et al., Characterisation of the first 250 000 hospital admissions for COVID-19 in Brazil: a retrospective analysis of nationwide data, Lancet Respir Med
Research, De, FDA cautions against use of hydroxychloroquine or chloroquine for COVID-19 outside of the hospital setting or a clinical trial due to risk of heart rhythm problems, FDA
Rubin, Estimating causal effects of treatments in randomized and nonrandomized studies. -PsycNET, J Educ Psychol
Sarkar, Soni, Khanna, Convalescent plasma is a clutch at straws in COVID-19 management! A systematic review and meta-analysis, J Med Virol
Serafim, Póvoa, Souza-Dantas, Kalil, Salluh, Clinical course and outcomes of critically ill patients with COVID-19 infection: a systematic review, Clin Microbiol Infect
Smith, Boppana, Traupman, Unson, Maddock et al., Impaired glucose metabolism in patients with diabetes, prediabetes, and obesity is associated with severe COVID-19, J Med Virol
Suleyman, Fadel, Malette, Hammond, Abdulla et al., Clinical Characteristics and Morbidity Associated With Coronavirus Disease 2019 in a Series of Patients in Metropolitan Detroit, JAMA Netw Open
Xie, Wu, Li, Hu, Hu et al., Clinical characteristics and outcomes of critically ill patients with novel coronavirus infectious disease (COVID-19) in China: a retrospective multicenter study, Intensive Care Med
Yang, Yu, Xu, Shu, Xia et al., Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study, Lancet Respir Med
Yao, Ye, Zhang, Cui, Huang et al., Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), Clin Infect Dis
Yu, Li, Chen, Zhou, Wang et al., Low dose of hydroxychloroquine reduces fatality of critically ill patients with COVID-19, Sci China Life Sci
Zhou, Yu, Du, Fan, Liu et al., Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study, The Lancet
Late treatment
is less effective
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