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0 0.5 1 1.5 2+ Hospitalization 94% Improvement Relative Risk Viral+ at day 14 96% HCQ for COVID-19  Simova et al.  EARLY TREATMENT Is early treatment with HCQ + AZ and zinc beneficial for COVID-19? Retrospective 38 patients in Bulgaria Lower hospitalization (p=0.014) and improved viral clearance (p=0.0012) Simova et al., New Microbes and New In.., Nov 2020 Favors HCQ Favors control

Hydroxychloroquine for prophylaxis and treatment of COVID-19 in health care workers

Simova et al., New Microbes and New Infections, doi:10.1016/j.nmni.2020.100813
Nov 2020  
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100% reduction in hospitalization and cases with early treatment using HCQ+AZ+zinc. Brief report on healthcare workers in Bulgaria.
0 hospitalizations with treatment vs. 2 for control
0 PCR+ at day 14 with treatment vs. 3 for control
33 treatment patients and 5 control patients.
No serious adverse events. This paper reports on both PEP and early treatment, we have separated the two studies.
risk of hospitalization, 93.8% lower, RR 0.06, p = 0.01, treatment 0 of 33 (0.0%), control 2 of 5 (40.0%), NNT 2.5, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
risk of viral+ at day 14, 95.8% lower, RR 0.04, p = 0.001, treatment 0 of 33 (0.0%), control 3 of 5 (60.0%), NNT 1.7, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Simova et al., 12 Nov 2020, retrospective, Bulgaria, peer-reviewed, 5 authors, dosage 200mg tid days 1-14, this trial uses multiple treatments in the treatment arm (combined with AZ and zinc) - results of individual treatments may vary.
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Abstract: LETTER TO THE EDITOR Hydroxychloroquine for prophylaxis and treatment of COVID-19 in health-care workers I. Simova1,2, T. Vekov2, J. Krasnaliev1,2, V. Kornovski2,3 and P. Bozhinov1,2 1) Heart and Brain—University Hospital, Pleven, 2) Bulgarian Cardiac Institute, Sofia and 3) Heart and Brain—University Hospital, Burgas, Bulgaria Keywords: COVID-19, health-care workers, hydroxychloroquine, prophylaxis, treatment Original Submission: 19 October 2020; Revised Submission: 28 October 2020; Accepted: 6 November 2020 Article published online: 12 November 2020 Corresponding author: I. Simova, Heart and Brain—University Hospital, Pleven, Bulgaria. E-mail: To the Editor, Providing adequate health care is vitally important during the coronavirus disease 2019 (COVID-19) pandemic to keep morbidity and mortality low. Health-care workers (HCW) are key guarantees for this process, and they must feel safe and adequately protected, which includes reliable prophylactic measures [1]. Hydroxychloroquine (HCQ) could exert antiviral effects, essential for prophylaxis and early treatment of COVID-19, through several mechanisms: (a) endosomal pH increase, which inhibits the passage of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) through the host cells’ membranes; (b) inhibition of angiotensin-converting enzyme 2 cell receptor glycosylation, which impedes SARS-CoV-2–receptor binding; (c) blocking the transport of SARS-CoV-2 from early endosomes to endolysosomes, which prevents release of the viral genome; (d) immunomodulation; and (e) limiting the post-viral cytokine storm syndrome [2,3]. We share here the experience of the Bulgarian Cardiac Institute (BCI) regarding the use of HCQ for prophylaxis and treatment of COVID-19 in HCW. The BCI comprises seven hospitals and eight medical centres, with around 1200 HCW, covering more than two-thirds of Bulgarian territory. Since March 2020, many of our employees have been in close contact with individuals with COVID-19. We offered prophylaxis with HCQ 200 mg daily for 14 days to 204 of them. In all, 76.4% of the group (156 HCW) used HCQ and none of them presented with COVID19 symptoms. Of the 48 HCW that refused HCQ prophylaxis, three developed symptoms and tested positive for COVID-19. During the last 7 months, 38 HCW at BCI have tested positive for COVID-19, half of them were symptomatic. We suggest the following treatment regimen as an early homebased therapy for them: azithromycin 500 mg daily; HCQ 200 mg three times a day and zinc up to 50 mg daily for 14 days. Thirty-three (86.8%) of them undertook this treatment, their symptoms disappeared between days 2 and 4, none of them required hospitalization and all had a negative PCR test on day 14. The other five HCW (13.2%) used alternative treatment regimens, none of them including HCQ. Three of them still tested positive at day 14 and two of them required hospitalization. All HCW (189) treated with HCQ, also took zinc. We performed electrocardiograms at baseline, and on day 3 and day 5 of HCQ treatment using a QTc measurement: baseline QTc was 412 ± 23 ms, day 3 QTc was 429 ± 27 ms and day 5 QTc was 427 ± 31 ms (p > 0.05 for all comparisons). We registered a QTc increase 60 ms in five HCW. QTc increased >470 ms in one male HCW and >480 ms in three female HCW. On all of these occasions HCQ was stopped. We did not register any rhythm disorders. A possible drawback of HCQ prophylaxis is the risk for selecting resistant..
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