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0 0.5 1 1.5 2+ Mortality 12% unadjusted Improvement Relative Risk Shousha et al. HCQ for COVID-19 LATE TREATMENT Is late treatment with HCQ beneficial for COVID-19? Retrospective 547 patients in Egypt (April - July 2020) Study underpowered to detect differences Shousha et al., World J. Gastroenterology, doi:10.3748/wjg.v27.i40.6951 Favors HCQ Favors control
Hepatic and gastrointestinal disturbances in Egyptian patients infected with coronavirus disease 2019: A multicentre cohort study
Shousha et al., World Journal of Gastroenterology, doi:10.3748/wjg.v27.i40.6951
Shousha et al., Hepatic and gastrointestinal disturbances in Egyptian patients infected with coronavirus disease 2019: A.., World Journal of Gastroenterology, doi:10.3748/wjg.v27.i40.6951
Oct 2021   Source   PDF  
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Retrospective 547 hospitalized COVID+ patients in Egypt, showing no significant differences with CQ/HCQ treatment in unadjusted analysis. Treatments were applied according to patient conditions, demographics, and comorbidities as per the the official guidelines, indicating strong confounding by indication. This study is excluded in meta analysis: confounding by indication, unadjusted results and treatment used selectively per official protocol; unadjusted results with no group details.
risk of death, 11.5% lower, RR 0.88, p = 0.87, treatment 12 of 136 (8.8%), control 41 of 411 (10.0%), NNT 87, unadjusted.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Shousha et al., 28 Oct 2021, retrospective, Egypt, peer-reviewed, 18 authors, study period 15 April, 2020 - 29 July, 2020.
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Abstract: ISSN 1007-9327 (print) ISSN 2219-2840 (online) World Journal of Gastroenterology World J Gastroenterol 2021 October 28; 27(40): 6737-7004 Published by Baishideng Publishing Group Inc WJ G World Journal of Gastroenterology Contents Weekly Volume 27 Number 40 October 28, 2021 FRONTIER 6737 Hepatocellular carcinoma risk after viral response in hepatitis C virus-advanced fibrosis: Who to screen and for how long? Ahumada A, Rayón L, Usón C, Bañares R, Alonso Lopez S OPINION REVIEW 6750 Higher doses of ascorbic acid may have the potential to promote nutrient delivery via intestinal paracellular absorption Sequeira IR EVIDENCE REVIEW 6757 Venous and arterial thromboembolism in patients with inflammatory bowel diseases Stadnicki A, Stadnicka I REVIEW 6775 Understanding the immune response and the current landscape of immunotherapy in pancreatic cancer Ostios-Garcia L, Villamayor J, Garcia-Lorenzo E, Vinal D, Feliu J 6794 Artificial intelligence in gastroenterology: A state-of-the-art review Kröner PT, Engels MM, Glicksberg BS, Johnson KW, Mzaik O, van Hooft JE, Wallace MB, El-Serag HB, Krittanawong C MINIREVIEWS 6825 Emerging artificial intelligence applications in liver magnetic resonance imaging Hill CE, Biasiolli L, Robson MD, Grau V, Pavlides M 6844 Role of human nucleoside transporters in pancreatic cancer and chemoresistance Carter CJ, Mekkawy AH, Morris DL 6861 Management of hepatitis B and C in special population Kulkarni AV, Duvvuru NR 6874 Endoscopic ultrasound-guided vascular interventions: Current insights and emerging techniques Mann R, Goyal H, Perisetti A, Chandan S, Inamdar S, Tharian B WJG I October 28, 2021 Volume 27 Issue 40 World Journal of Gastroenterology Contents Weekly Volume 27 Number 40 October 28, 2021 ORIGINAL ARTICLE Basic Study 6888 Metabolomics of Fuzi-Gancao in CCl4 induced acute liver injury and its regulatory effect on bile acid profile in rats Wang MF, Zhao SS, Thapa DM, Song YL, Xiang Z 6908 Transforming growth factor beta-1 upregulates glucose transporter 1 and glycolysis through canonical and noncanonical pathways in hepatic stellate cells Zhou MY, Cheng ML, Huang T, Hu RH, Zou GL, Li H, Zhang BF, Zhu JJ, Liu YM, Liu Y, Zhao XK Retrospective Cohort Study 6927 Serum hepatitis B core-related antigen as a surrogate marker of hepatitis B e antigen seroconversion in chronic hepatitis B Chi XM, Wang XM, Wang ZF, Wu RH, Gao XZ, Xu HQ, Ding YH, Niu JQ 6939 Long-term follow-up of liver alveolar echinococcosis using echinococcosis multilocularis ultrasound classification Schuhbaur J, Schweizer M, Philipp J, Schmidberger J, Schlingeloff P, Kratzer W Observational Study 6951 Hepatic and gastrointestinal disturbances in Egyptian patients infected with coronavirus disease 2019: A multicentre cohort study Shousha HI, Afify S, Maher R, Asem N, Fouad E, Mostafa EF, Medhat MA, Abdalazeem A, Elmorsy H, Aziz MM, Mohammed RS, Ibrahem M, Elgarem H, Omran D, Hassany M, Elsayed B, Abdelaziz AY, El Kassas M 6967 Factors affecting anxiety, depression, and self-care ability in patients who have undergone liver transplantation Akbulut S, Ozer A, Saritas H, Yilmaz S META-ANALYSIS 6985 Prophylactic transcatheter arterial embolization reduces rebleeding in non-variceal upper gastrointestinal bleeding: A meta-analysis Boros E, Sipos Z, Hegyi P, Teutsch B, Frim L, Váncsa S, Kiss S, Dembrovszky F, Oštarijaš E, Shawyer A, Erőss B LETTER TO THE..
Late treatment
is less effective
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