Abstract: diabetes research and clinical practice 172 (2021) 108538 Contents available at ScienceDirect Diabetes Research and Clinical Practice journal homepage: www.elsevier.com/locat e/dia bre s Prevalence of diabetes, management and outcomes among Covid-19 adult patients admitted in a specialized tertiary hospital in Riyadh, Saudi Arabia Eman Sheshah a, Shaun Sabico b, Rashed M. Albakr c, Anmar A. Sultan c, Khalaf S. Alghamdi c, Khaled Al Madani d, Hadil A. Alotair e, Nasser M. Al-Daghri b,* a Diabetes Care Center, King Salman Bin Abdulaziz Hospital, Riyadh 12769, Saudi Arabia Biochemistry Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia c King Salman Bin Abdulaziz Hospital, Riyadh 12769, Saudi Arabia d Family Medicine Department, College of Medicine, King Abdulaziz Medical City, Riyadh, Saudi Arabia e Department of Medicine, King Saud University Medical City, Riyadh, Saudi Arabia b A R T I C L E I N F O A B S T R A C T Article history: This retrospective study aimed to characterize comorbidities and associated with mortality Received 1 September 2020 among hospitalized adults with Covid-19 managed as per the Saudi Ministry of Health pro- Received in revised form tocol in a specialized tertiary hospital in Riyadh, Saudi Arabia. Medical records of 300 adult 21 October 2020 patients with PCR-confirmed SARS-CoV2 infection and admitted in King Salman Hospital Accepted 30 October 2020 (KSH) from May 1 to July 31, 2020 were included. Medical history, management and out- Available online 13 November 2020 comes were noted. Males significantly outnumber females (259 versus 41). South Asians comprise 41% of all admitted patients. Mortality rate was 10% and highest among Saudi Keywords: Type 2 Diabetes Mellitus Covid-19 Saudi Arabia South Asians males (28.9%). Type 2 diabetes mellitus (T2DM) was the most common comorbidity (45.7%). Almost all patients (99%) had pneumonia. Patients > 50 years were three times more likely to die (confidence interval, CI 1.3–6.9; p = 0.01) from Covid-19. Congestive heart failure (odds ratio OR 19.4, CI-1.5–260.0; p = 0.02) and acute kidney injury (OR 11.7, CI-4.7– 28.6; p < 0.001) were significantly associated with higher mortality. Dexamethasone use significantly improved the final outcome based on net reclassification improvement (NRI) and integrated discrimination improvement (IDI) (p < 0.05). In this single-center study, T2DM was very common among hospitalized Covid-19 patients. Patients > 50 years, those with congestive heart failure and acute kidney injury are at higher risk for worse Covid-19 outcome. Ó 2020 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). * Corresponding author at: Biochemistry Department, College of Science, King, Saud University, PO, Box, 2455, Riyadh 11451, Saudi Arabia. E-mail address: ndaghri@ksu.edu.sa (N.M. Al-Daghri). https://doi.org/10.1016/j.diabres.2020.108538 0168-8227/Ó 2020 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). 2 1. diabetes research and clinical practice