Prevalence of Diabetes, Management and Outcomes among Covid-19 Adult Patients Admitted in a Specialized Tertiary Hospital in Riyadh, Saudi Arabia
Sheshah et al.
, Prevalence of Diabetes, Management and Outcomes among Covid-19 Adult Patients Admitted in a Specialized..
, Diabetes Research and Clinical Practice, doi:10.1016/j.diabres.2020.108538
Retrospective 300 hospitalized patients in Saudi Arabia showing HCQ adjusted odds ratio aOR 0.12, p < 0.001.
risk of death, 80.0% lower, RR 0.20, p < 0.001, treatment 267, control 33, odds ratio converted to relative risk.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Sheshah et al., 13 Nov 2020, retrospective, Saudi Arabia, peer-reviewed, 8 authors.
Abstract: diabetes research and clinical practice
172 (2021) 108538
Contents available at ScienceDirect
and Clinical Practice
journal homepage: www.elsevier.com/locat e/dia bre s
Prevalence of diabetes, management and outcomes
among Covid-19 adult patients admitted in a
specialized tertiary hospital in Riyadh, Saudi
Eman Sheshah a, Shaun Sabico b, Rashed M. Albakr c, Anmar A. Sultan c,
Khalaf S. Alghamdi c, Khaled Al Madani d, Hadil A. Alotair e, Nasser M. Al-Daghri b,*
Diabetes Care Center, King Salman Bin Abdulaziz Hospital, Riyadh 12769, Saudi Arabia
Biochemistry Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia
King Salman Bin Abdulaziz Hospital, Riyadh 12769, Saudi Arabia
Family Medicine Department, College of Medicine, King Abdulaziz Medical City, Riyadh, Saudi Arabia
Department of Medicine, King Saud University Medical City, Riyadh, Saudi Arabia
A R T I C L E I N F O
A B S T R A C T
This retrospective study aimed to characterize comorbidities and associated with mortality
Received 1 September 2020
among hospitalized adults with Covid-19 managed as per the Saudi Ministry of Health pro-
Received in revised form
tocol in a specialized tertiary hospital in Riyadh, Saudi Arabia. Medical records of 300 adult
21 October 2020
patients with PCR-confirmed SARS-CoV2 infection and admitted in King Salman Hospital
Accepted 30 October 2020
(KSH) from May 1 to July 31, 2020 were included. Medical history, management and out-
Available online 13 November 2020
comes were noted. Males significantly outnumber females (259 versus 41). South Asians
comprise 41% of all admitted patients. Mortality rate was 10% and highest among Saudi
Type 2 Diabetes Mellitus
males (28.9%). Type 2 diabetes mellitus (T2DM) was the most common comorbidity
(45.7%). Almost all patients (99%) had pneumonia. Patients > 50 years were three times
more likely to die (confidence interval, CI 1.3–6.9; p = 0.01) from Covid-19. Congestive heart
failure (odds ratio OR 19.4, CI-1.5–260.0; p = 0.02) and acute kidney injury (OR 11.7, CI-4.7–
28.6; p < 0.001) were significantly associated with higher mortality. Dexamethasone use significantly improved the final outcome based on net reclassification improvement (NRI) and
integrated discrimination improvement (IDI) (p < 0.05). In this single-center study, T2DM
was very common among hospitalized Covid-19 patients. Patients > 50 years, those with
congestive heart failure and acute kidney injury are at higher risk for worse Covid-19
Ó 2020 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
* Corresponding author at: Biochemistry Department, College of Science, King, Saud University, PO, Box, 2455, Riyadh 11451, Saudi
E-mail address: firstname.lastname@example.org (N.M. Al-Daghri).
0168-8227/Ó 2020 The Author(s). Published by Elsevier B.V.
This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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