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0 0.5 1 1.5 2+ Symp. case 19% Improvement Relative Risk Case -6% Case (b) -22% HCQ for COVID-19  Shabani et al.  Prophylaxis Is post-exposure prophylaxis with HCQ beneficial for COVID-19? Prospective study of 113 patients in Iran Study underpowered to detect differences Shabani et al., Pulmonary Pharmacology.., Aug 2021 Favors HCQ Favors control

Evaluation of the Prophylactic Effect of Hydroxychloroquine on People in Close-Contact with Patients with Covid-19

Shabani et al., Pulmonary Pharmacology & Therapeutics, doi:10.1016/j.pupt.2021.102069
Aug 2021  
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Small PEP trial with 51 HCQ patients, not showing a significant difference in cases. IRCT20130917014693N10.
risk of symptomatic case, 19.0% lower, RR 0.81, p = 1.00, treatment 2 of 51 (3.9%), control 3 of 62 (4.8%), NNT 109, day 7.
risk of case, 6.4% higher, RR 1.06, p = 1.00, treatment 7 of 51 (13.7%), control 8 of 62 (12.9%), day 7, PCR+ and symptomatic.
risk of case, 21.6% higher, RR 1.22, p = 0.78, treatment 7 of 51 (13.7%), control 7 of 62 (11.3%), day 7, PCR+ only.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Shabani et al., 10 Aug 2021, prospective, Iran, peer-reviewed, 16 authors.
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This PaperHCQAll
Evaluation of the prophylactic effect of hydroxychloroquine on people in close-contact with patients with COVID-19
Minoosh Shabani, Mehdi Totonchi, Omidvar Rezaeimirghaed, Latif Gachkar, Mohammadreza Hajiesmaeili, Ali Khoshkar, Mahdi Amirdosara, Ali Saffaei, Shervin Shokouhi, Masoud Mardani, Ilad Alavi Darazam, Alireza Karami, Milad Sharifi, Mana Zaman, Elham Abedheydari, Dr Zahra Sahraei
Pulmonary Pharmacology & Therapeutics, doi:10.1016/j.pupt.2021.102069
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Shabani Barzegar ; Zhou, Yang, Wang, Hu, Zhang et al., Conceptualization, Methodology, Investigation, Data Curation, Writing -Original Draft, Writing -Review & Editing, Project administration Mehdi Totonchi: Conceptualization, Data Curation, Formal analysis Writing -Review & Editing Omidvar Rezaeimirghaed: Conceptualization, Data Curation, Writing -Review & Editing Latif Gachkar: Conceptualization, Data Curation, Writing -Review & Editing Mohammadreza Hajiesmaeili: Conceptualization, Data Curation, Writing -Review & Editing Ali Khoshkar: Conceptualization, Data Curation, Writing -Review & Editing Mahdi Amirdosara: Conceptualization, Data Curation, Writing -Review & Editing Ali Saffaei: Conceptualization, Data Curation, Formal analysis, Writing -Review & Editing Shervin Shokouhi: Conceptualization, Data Curation, Writing -Review & Editing Masoud Mardani: Conceptualization, Data Curation, Writing -Review & Editing Ilad Alavi Darazam: Conceptualization, Data Curation, Writing
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