Shabani: Evaluation of the Prophylactic Effect of Hydroxychloroquine on People in Close-Contact with Patients with Covid-19 [HCQ]

Evaluation of the Prophylactic Effect of Hydroxychloroquine on People in Close-Contact with Patients with Covid-19

Shabani et al., Pulmonary Pharmacology & Therapeutics, doi:10.1016/j.pupt.2021.102069

Shabani et al., Evaluation of the Prophylactic Effect of Hydroxychloroquine on People in Close-Contact with Patients with.., Pulmonary Pharmacology & Therapeutics, doi:10.1016/j.pupt.2021.102069

Aug 2021 Source PDF

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Small PEP trial with 51 HCQ patients, not showing a significant difference in cases. IRCT20130917014693N10.

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risk of symptomatic case, 19.0% lower, RR 0.81, p = 1.00, treatment 2 of 51 (3.9%), control 3 of 62 (4.8%), NNT 109, day 7.

risk of case, 6.4% higher, RR 1.06, p = 1.00, treatment 7 of 51 (13.7%), control 8 of 62 (12.9%), day 7, PCR+ and symptomatic.

risk of case, 21.6% higher, RR 1.22, p = 0.78, treatment 7 of 51 (13.7%), control 7 of 62 (11.3%), day 7, PCR+ only.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates

Shabani et al., 10 Aug 2021, prospective, Iran, peer-reviewed, 16 authors.

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Abstract: Journal Pre-proof Evaluation of the Prophylactic Effect of Hydroxychloroquine on People in CloseContact with Patients with Covid-19 Minoosh Shabani, Mehdi Totonchi, Omidvar Rezaeimirghaed, Latif Gachkar, Mohammadreza Hajiesmaeili, Ali Khoshkar, Mahdi Amirdosara, Ali Saffaei, Shervin Shokouhi, Masoud Mardani, Ilad Alavi Darazam, Alireza Karami, Milad Sharifi, Mana Zaman, Elham Abedheydari, Zahra Sahraei PII: S1094-5539(21)00081-X DOI: https://doi.org/10.1016/j.pupt.2021.102069 Reference: YPUPT 102069 To appear in: Pulmonary Pharmacology & Therapeutics Received Date: 9 February 2021 Revised Date: 4 August 2021 Accepted Date: 7 August 2021 Please cite this article as: Shabani M, Totonchi M, Rezaeimirghaed O, Gachkar L, Hajiesmaeili M, Khoshkar A, Amirdosara M, Saffaei A, Shokouhi S, Mardani M, Darazam IA, Karami A, Sharifi M, Zaman M, Abedheydari E, Sahraei Z, Evaluation of the Prophylactic Effect of Hydroxychloroquine on People in Close-Contact with Patients with Covid-19, Pulmonary Pharmacology & Therapeutics, https:// doi.org/10.1016/j.pupt.2021.102069. This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. © 2021 Published by Elsevier Ltd. Minoosh Shabani Barzegar: Conceptualization, Methodology, Investigation, Data Curation, Writing - Original Draft, Writing - Review & Editing, Project administration Mehdi Totonchi: Conceptualization, Data Curation, Formal analysis Writing - Review & Editing Omidvar Rezaeimirghaed: Conceptualization, Data Curation, Writing - Review & Editing Latif Gachkar: Conceptualization, Data Curation, Writing - Review & Editing Mohammadreza Hajiesmaeili: Conceptualization, Data Curation, Writing - Review & Editing Ali Khoshkar: Conceptualization, Data Curation, Writing - Review & Editing oo f Mahdi Amirdosara: Conceptualization, Data Curation, Writing - Review & Editing Ali Saffaei: Conceptualization, Data Curation, Formal analysis, Writing - Review & Editing re -p r Shervin Shokouhi: Conceptualization, Data Curation, Writing - Review & Editing Masoud Mardani: Conceptualization, Data Curation, Writing - Review & Editing lP Ilad Alavi Darazam: Conceptualization, Data Curation, Writing - Review & Editing Alireza Karami: Conceptualization, Data Curation, Writing - Review & Editing ur na Milad Sharifi: Conceptualization, Data Curation, Writing - Review & Editing Mana Zaman: Conceptualization, Data Curation, Writing - Review & Editing Jo Elham Abedheydari: Conceptualization, Data Curation, Writing - Review & Editing Zahra Sahraei: Conceptualization, Methodology, Investigation, Data Curation, Writing Original Draft, Writing - Review & Editing, Supervision Evaluation of the Prophylactic Effect of Hydroxychloroquine on People in Close-Contact with Patients with Covid-19 Minoosh Shabani a,b,§, Mehdi Totonchic,d,§ , Omidvar Rezaeimirghaed e , Latif Gachkar a,b, Mohammadreza Hajiesmaeili f , Ali Khoshkar g , Mahdi Amirdosara f , Ali Saffaei h , Shervin Shokouhi a,b, Masoud Mardani a,b , Ilad..

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