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0 0.5 1 1.5 2+ Mortality -14% Improvement Relative Risk HCQ for COVID-19  Salehi et al.  ICU PATIENTS Is very late treatment with HCQ beneficial for COVID-19? Retrospective 125 patients in Iran (April - September 2021) No significant difference in mortality c19hcq.org Salehi et al., Research Square, March 2022 Favors HCQ Favors control

Risk factors of death in mechanically ventilated COVID-19 patients: a retrospective multi-center study

Salehi et al., Research Square, doi:10.21203/rs.3.rs-1362678/v1
Mar 2022  
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HCQ for COVID-19
1st treatment shown to reduce risk in March 2020
 
*, now known with p < 0.00000000001 from 421 studies, recognized in 42 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
3,800+ studies for 60+ treatments. c19hcq.org
Retrospective 125 mechanically ventilated ICU patients in Iran, showing no significant difference with HCQ treatment in unadjusted results.
This study is excluded in the after exclusion results of meta analysis: unadjusted results with no group details.
Study covers remdesivir, HCQ, and vitamin C.
risk of death, 14.5% higher, RR 1.14, p = 0.44, treatment 53 of 86 (61.6%), control 21 of 39 (53.8%).
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Salehi et al., 11 Mar 2022, retrospective, Iran, preprint, mean age 62.0, 11 authors, study period April 2021 - September 2021.
This PaperHCQAll
Risk factors of death in mechanically ventilated COVID-19 patients: a retrospective multi- center study
Mohammadreza Salehi, Mohammad-Taghi Beig Mohammadi, Seyed Hamidreza Abtahi, Samrand-Fattah Ghazi, Abolfazl Sobati, Rama Bozorgmehr, Seyed Ali Dehghan Manshadi, Saeed Reza Jamali Siahkali, Mostafa Mohammadi, Banafsheh Moradmand Badie, Ensiyeh Rahimi
doi:10.21203/rs.3.rs-1362678/v1
Introduction: Despite the improvement in COVID-19 therapeutic management the mortality of mechanically ventilated COVID-19 patients remains high. In this study, we determined risk factors of mortality in these cases. Methods: This retrospective study examined clinical and paraclinical data of COVID-19 patients mechanically ventilated at the time of hospitalization to ICU admission until death or discharge from hospital between April and September in 2021 in three COVID-19 referral hospitals. Results: One hundred twenty-ve patients (60% male, mean age 62 ± 15.18, range 17 to 97 years old) were recruited to this study. 51(40%) survived and 74 (60%) didn't survive. At the time of hospital admission, the vital signs were not signi cantly different between the survivors and non-survivors groups, also diarrhea was not reported in non-survivors, but reported in 9.5% of survivors (P = 0.02). The mean age of 74 non-survivors was higher than 51 survivors (65.1 ± 14.17 vs 56.9 ± 15.41, P = 0.003). The intubation time since the patients were admitted to hospitals was not signi cantly different between the two groups (3.38 ± 2.88 days vs 4.16 ± 3.42 days, P = 0.34). The mean LDH and D-dimer at the time of ICU admission were signi cantly higher in the non-survivors group (863 ± 449 vs 613 ± 326, P = 0.01; 4081 ± 3342 vs 542 ± 634, P = 0.009; respectively). However, the mean CRP was not signi cantly different between the two groups (76 ± 66.4, 54 ± 84.3; P = 0.1). Mean APACHE-II score was higher in the non-survivors than the survivors (15 vs 13; P = 0.01). Use of remdesivir, interfrone beta-1a, and low dose corticosteroids were signi cantly higher in the survivors group (P = 0.009, P = 0.001, P = 0.000). Conclusion: Success of weaning and hospital discharge among mechanically ventilated COVID-19 patients are probably higher in younger patients with lower D-dimmer and LDH levels that received low dose corticosteroids during treatment.
The study is retrospective. It was not possible to use written consent. According to the Medical Ethics Committee, patients' information remains con dential. Patients agreed to receive routine treatment upon arrival at the hospital. Then they received the treatment they needed. Finally, they were analyzed based on the treatment received in different groups. Consent for publication: We the authors give our consent for the publication of identi able details within the text to be published in the Journal of Critical Care.
References
Arentz, Yim, Klaff, Lokhandwala, Riedo et al., Characteristics and Outcomes of 21 Critically Ill Patients With COVID-19 in Washington State, JAMA, doi:10.1001/jama.2020.4326
Assiri, Al-Taw Q, Aa, Fa, Al-Hajjar, Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study, Lancet Infect Dis, doi:10.1016/S14733099(13)70204-4
Bauer, Gajic, Nanchal, Kashyap, Martin-Loeches et al., Association between timing of intubation and outcome in critically ill patients: a secondary analysis of the ICON audit, J Crit Care
Bauer, Gajic, Nanchal, Kashyap, Martin-Loeches et al., Association between timing of intubation and outcome in critically ill patients: a secondary analysis of the ICON audit, J Crit Care
Bavishi1, Mylvaganam2, Agrawal3, Avery3, Cuttica4, Early vs Late Intubation in COVID-19 Acute Respiratory Distress Syndrome: A Retrospective Study of Ventilator Mechanics, Computed Tomography Findings, and Outcomes, Am J Respir Crit Care Med
Bavishi1, Mylvaganam2, Agrawal3, Avery3, Cuttica4, Early vs Late Intubation in COVID-19 Acute Respiratory Distress Syndrome: A Retrospective Study of Ventilator Mechanics, Computed Tomography Findings, and Outcomes, Am J Respir Crit Care Med
Beigel, Tomashek, Dodd, Mehta, Zingman et al., Remdesivir for the Treatment of Covid-19 -Final Report, N Engl J Med, doi:10.1056/NEJMoa2007764
Bhargava, Fukushima, Levine, Zhao, Tanveer et al., Predictors for Severe COVID-19 Infection, Clin Infect Dis
Bhargava, Fukushima, Levine, Zhao, Tanveer et al., Predictors for Severe COVID-19 Infection, Clin Infect Dis
Bhatraju, Ghassemieh, Nichols, Kim, Jerome et al., Covid-19 in Critically Ill Patients in the Seattle Region-Case Series, N Engl J Med, doi:10.1056/NEJMoa2004500
Bhatraju, Ghassemieh, Nichols, Kim, Jerome et al., Covid-19 in Critically Ill Patients in the Seattle Region-Case Series, N Engl J Med, doi:10.1056/NEJMoa2004500PMID:32227758
Bhimraj, Morgan, Shumaker, Lavergne, Baden et al., Infectious Diseases Society of America Guidelines on the Treatment and Management of Patients With Coronavirus Disease
Bosi, Bosi, Rovere Querini, Interferon β-1a (IFNβ-1a) in COVID-19 patients (INTERCOP): study protocol for a randomized controlled trial, Trials, doi:10.1186/s13063-020-04864-4
Brewster, Chrimes, Do, Fraser, Groombridge et al., Consensus statement: Safe Airway Society principles of airway management and tracheal intubation speci c to the COVID-19 adult patient group, Med J Aust
Brown, Mosier, Carlson, Gibbs, Pragmatic recommendations for intubating critically ill patients with suspected COVID-19, J Am Coll Emerg Phys Open
Chen, Zhou, Dong, Qu, Gong et al., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study, Lancet
Cheng, Luo, Wang, Zhang, Wang et al., Risk of pneumonia among patients with chronic kidney disease in outpatient and inpatient settings, Kidney Int
Cilloniz, Polverino, Ewig, Aliberti, Gabarrus et al., Impact of age and comorbidity on cause and outcome in community-acquired pneumonia, Chest, doi:10.1378/chest.13-0062
Cook, El-Boghdadly, Mcguire, Mcnarry, Patel et al., Consensus guidelines for managing the airway in patients with COVID-19: Guidelines from the Di cult Airway Society, the Association of Anaesthetists the Intensive Care Society, the Faculty of Intensive Care Medicine and the Royal College of Anaesthetists, Anaesth Blackwell Publ
Edalatifard, Akhtari, Salehi, Intravenous methylprednisolone pulse as a treatment for hospitalised severe COVID-19 patients: results from a randomised controlled clinical trial, Eur Respir J, doi:10.1183/13993003.02808-2020
Flynn, Moloney, Bhattarai, Scott, Breckons et al., COVID-19 pandemic in the United Kingdom, Health Policy Technol
Fu, Wang, Yuan, Chen, Ao et al., Clinical characteristics of coronavirus disease 2019 (COVID-19) in China: A systematic review and meta-analysis, J Infect, doi:10.1016/j.jinf.2020.03.041
Grasselli, Zangrillo, Zanella, Antonelli, Cabrini et al., Baseline characteristics and outcomes of 1591 patients infected with SARS-CoV-2 admitted to ICUs of the Lombardy Region. Italy, JAMA
Guan, Liang, Zhao, Liang, Chen et al., Comorbidity and its impact on 1590 patients with Covid-19 in China: a nationwide analysis, Eur Respir J
Guan, Liang, Zhao, Liang, Chen et al., Comorbidity and its impact on 1590 patients with Covid-19 in China: a nationwide analysis, Eur Respir J
Henry, Aggarwal, Wong, Benoit, Vikse et al., Lactate dehydrogenase levels predict coronavirus disease 2019 (COVID-19) severity and mortality: a pooled analysis, Am J Emerg Med
Henry, Aggarwal, Wong, Benoit, Vikse et al., Lactate dehydrogenase levels predict coronavirus disease 2019 (COVID-19) severity and mortality: a pooled analysis, Am J Emerg Med
Henry, Lippi, Chronic kidney disease is associated with severe coronavirus disease 2019 (COVID-19) infection, Int Urol Nephrol
Horby, Mafham, Linsell, Bell, Staplin et al., Effect of Hydroxychloroquine in Hospitalized Patients with Covid-19, N Engl J Med, doi:10.1056/NEJMoa2022926
Huang, Wang, Li, Ren, Zhao et al., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China, Lancet, doi:10.1016/S0140-6736(20)30183-5
Huang, Wang, Li, Ren, Zhao et al., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China, Lancet, doi:10.1016/S0140-6736(20)30183-5
Kang, Koh, Lim, Huh, Baek et al., Failure of high-ow nasal cannula therapy may delay intubation and increase mortality, Intensive Care
Kang, Koh, Lim, Huh, Baek et al., Failure of high-ow nasal cannula therapy may delay intubation and increase mortality, Intensive Care
Kangelaris, Ware, Wang, Janz, Zhuo et al., Timing of intubation and clinical outcomes in adults with acute respiratory distress syndrome, Crit Care Med
Kangelaris, Ware, Wang, Janz, Zhuo et al., Timing of intubation and clinical outcomes in adults with acute respiratory distress syndrome, Crit Care Med
Karolyi, Pawelka, Mader, Hydroxychloroquine versus lopinavir/ritonavir in severe COVID-19 patients, Wien Klin Wochenschr, doi:10.1007/s00508-020-01720-y
Kato, Fujisawa, Enomoto, Inui, Nakamura et al., Severe respiratory failure associated with in uenza B virus infection, Respirol Case Rep, doi:10.1002/rcr2.107
Kil, Lee, Lee, Rhim, Youn et al., Early corticosteroid treatment for severe pneumonia caused by 2009 H1N1 in uenza virus, Crit Care, doi:10.1186/cc10082
Ladha, Zhao, Quraishi, Kurth, Eikermann et al., The Deyo-Charlson and Elixhauser-van Walraven comorbidity indices as predictors of mortality in critically ill patients, BMJ Open, doi:10.1136/bmjopen-2015-008990
Lee, Hui, Wu, Chan, Cameron et al., A major outbreak of severe acute respiratory syndrome in Hong Kong, N Engl J Med, doi:10.1056/NEJMoa030685
Liu, Tao, Wang, Yuan, Liu et al., Analysis of factors associated with disease outcomes in hospitalized patients with 2019 novel coronavirus disease, Chinese Medical Journal, doi:10.1097/CM9.0000000000000775
Liu, Tao, Wang, Yuan, Liu et al., Analysis of factors associated with disease outcomes in hospitalized patients with 2019 novel coronavirus disease, Chinese Medical Journal, doi:10.1097/CM9.0000000000000775
Myers, Parodi, Escobar, Liu, Characteristics of Hospitalized Adults With COVID-19 in an Integrated Health Care System in California, JAMA, doi:10.1001/jama.2020.7202
Nina Farzan A, Vahabi B, Yaser Foroghi Ghomi A, Shirvani A, Shima Sadat Hashemi Madani C et al., Evaluation of invasive ventilation (intubation) prognosis in patients with Covid-19 Symptoms, International Journal of Surgery Open
Organization, Coronavirus disease
Pan, Peto, Karim, Alejandria, Repurposed antiviral drugs for COVID-19-interim WHO SOLIDARITY trial results, doi:10.1101/2020.10
Pandya, Ariyana Kaur, Sacher, Criner, Ventilatory Mechanics in Early vs Late Intubation in a Cohort of Coronavirus Disease 2019 Patients With ARDS, CRITICAL CARE: RESEARCH LETTERS| VOLUME, doi:10.1016/j.chest.2020.08.2084
Papoutsi, Giannakoulis, Xourgia, Ch, Kotanidou et al., Effect of timing of intubation on clinical outcomes of critically ill patients with COVID-19: a systematic review and meta-analysis of non-randomized cohort studies, doi:10.1186/s13054-021-03540-6
Papoutsi1, Vassilis, Giannakoulis1, Xourgia1, Kotanidou1 et al., Effect of timing of intubation on clinical outcomes of critically ill patients with COVID-19: a systematic review and meta-analysis of non-randomized cohort studies. Papoutsi et al, Crit Care, doi:10.1186/s13054-021-03540-6
Rahimzadeh, Faiz, Farahmandrad, Hassanlouei, Habibi et al., Clinical Features and Prognosis of Invasive Ventilation in Hospitalized Patients with COVID-19: A Retrospective Study, Anesth Pain Med, doi:10.5812/aapm.108773
Rahimzadeh, Faiz, Farahmandrad, Hassanlouei, Habibi et al., Clinical Features and Prognosis of Invasive Ventilation in Hospitalized Patients with COVID-19: A Retrospective Study, Anesth Pain Med, doi:10.5812/aapm.108773
Rahimzadeh, Faiz, Farahmandrad, Hassanlouei, Habibi et al., Clinical Features and Prognosis of Invasive Ventilation in Hospitalized Patients with COVID-19: A Retrospective Study, Anesth Pain Med, doi:10.5812/aapm.108773
Rahimzadeh, Faiz, Farahmandrad, Hassanlouei, Habibi et al., Clinical Features and Prognosis of Invasive Ventilation in Hospitalized Patients with COVID-19: A Retrospective Study, Anesth Pain Med, doi:10.5812/aapm.108773
Rahmani, Davoudi-Monfared, Nourian, Khalili, Hajizadeh et al., Interferon β-1b in treatment of severe COVID-19: A randomized clinical trial, Int Immunopharmacol, doi:10.1016/j.intimp.2020.106903
Sardu, Gambardella, Morelli, Wang, Marfella et al., Hypertension, thrombosis, kidney failure, and diabetes: Is COVID-19 an endothelial disease? A comprehensive evaluation of clinical and basic evidence, J Clin Med
Scully, Haver Eld, Ursin, Tannenbaum, Klein, Considering how biological sex impacts immune responses and COVID-19 outcomes, Nat Rev Immunol
Sharifpour, Rangaraju, Liu, Alabyad, Nahab et al., C-Reactive protein as a prognostic indicator in hospitalized patients with COVID-19, PLoS ONE, doi:10.1371/journal
Sharifpour, Rangaraju, Liu, Alabyad, Nahab et al., C-Reactive protein as a prognostic indicator in hospitalized patients with COVID-19, PLoS ONE, doi:10.1371/journal
Soy, Keser, Atagündüz, Tabak, Atagündüz et al., Cytokine storm in COVID-19: pathogenesis and overview of anti-in ammatory agents used in treatment, Clin Rheumatol
Tehrania, Killandera, Åstranda, Jakobssonb, Gille-Johnsona, Risk factors for death in adult COVID-19 patients: Frailty predicts fatal outcome in older patients, International Journal of Infectious Diseases, doi:10.1016/j.ijid.2020.10.071
Tehrania, Killandera, Åstranda, Jakobssonb, Gille-Johnsona, Risk factors for death in adult COVID-19 patients: Frailty predicts fatal outcome in older patients, International Journal of Infectious Diseases, doi:10.1016/j.ijid.2020.10.071
Ticinesi, Nouvenne, Folesani, Prati, Morelli et al., An investigation of multimorbidity measures as risk factors for pneumonia in elderly frail patients admitted to hospital, Eur J Intern Med, doi:10.1016/j.ejim.2015.11.021
Torres, Sibila, Ferrer, Polverino, Menendez et al., Effect of corticosteroids on treatment failure among hospitalized patients with severe community-acquired pneumonia and high in ammatory response: a randomized clinical trial, JAMA, doi:10.1001/jama.2015.88
Vita A, Scottia, Cammarotab, Raccac, Pissaiad et al., Predictors of intubation in COVID-19 patients treated with out-of-ICU continuous positive airway pressure, doi:10.1016/j.pulmoe.2020.12.010
Vita, Scotti, Cammarota, Raccac, Pissaiad et al., Predictors of intubation in COVID-19 patients treated with out-of-ICU continuous positive airway pressure, PULMOE, doi:10.1016/j.pulmoe.2020.12.010
Vita, Scotti, Cammarota, Raccac, Pissaiad et al., Predictors of intubation in COVID-19 patients treated with out-of-ICU continuous positive airway pressure, PULMOE, doi:10.1016/j.pulmoe.2020.12.010
Wang, C-reactive protein levels in the early stage of COVID-19, Médecine et maladies infectieuses, doi:10.1016/j.medmal.2020.03.007
Wang, Shu, Ran, Xie, Zhang, Critically Ill Patients with Coronavirus Disease 2019 in a Designated ICU: Clinical Features and Predictors for Mortality, Risk Management and Healthcare Policy
Wang, Shu, Ran, Xie, Zhang, Critically Ill Patients with Coronavirus Disease 2019 in a Designated ICU: Clinical Features and Predictors for Mortality, Risk Management and Healthcare Policy
Wang, Zhang, Du, Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial, Lancet
Wu, Chen, Cai, Xia, Zhou et al., Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China, JAMA Intern Med, doi:10.1001/jamainternmed.2020.0994
Wu, Mcgoogan, Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72314 Cases From the Chinese Center for Disease Control and Prevention, JAMA, doi:10.1001/jama.2020.2648
Wu, Mcgoogan, Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: Summary of a report of 72 314 cases from the Chinese center for disease control and prevention, JAMA
Wynants, Van Calster, Collins, Prediction models for diagnosis and prognosis of covid-19 infection: Systematic review and critical appraisal, BMJ
Xie, Tong, Guan, Du, Qiu et al., Critical care crisis and some recommendations during the COVID-19 epidemic in China, Intensive Care Med
Yang, Yu, Xu, Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: A single centered, retrospective, observational study, Lancet Respir Med, doi:10.1016/S2213-2600(20)30079-5
Zhou, Yu, Du, Fan, Liu et al., Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study, Lancet
Zhou, Yu, Du, Fan, Liu et al., Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study, Lancet
Zou, Li, Fang, Hu, Bian et al., Acute Physiology and Chronic Health Evaluation II Score as a Predictor of Hospital Mortality in Patients of Coronavirus Disease, Med, doi:10.1097/CCM
Zuo, Huang, Ma, Xue, Zhang et al., Expert recommendations for tracheal intubation in critically iii patients with noval coronavirus disease 2019, Chin Med Sci J
Late treatment
is less effective
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