Prognostic factors for the severity of SARS-CoV-2 infection

{ 'indexed': {'date-parts': [[2023, 6, 22]], 'date-time': '2023-06-22T04:07:25Z', 'timestamp': 1687406845847}, 'reference-count': 17, 'publisher': 'Walter de Gruyter GmbH', 'issue': '2', 'license': [ { 'start': { 'date-parts': [[2021, 3, 3]], 'date-time': '2021-03-03T00:00:00Z', 'timestamp': 1614729600000}, 'content-version': 'unspecified', 'delay-in-days': 0, 'URL': 'http://creativecommons.org/licenses/by/4.0'}], 'content-domain': {'domain': [], 'crossmark-restriction': False}, 'published-print': {'date-parts': [[2021, 5, 20]]}, 'abstract': '<jats:title>Abstract</jats:title>\n' ' <jats:sec id="j_almed-2021-0017_abs_001">\n' ' <jats:title>Objectives</jats:title>\n' ' <jats:p>Severe acute respiratory syndrome coronavirus (SARS-CoV-2) is a ' 'novel coronavirus that causes COVID-19. This disease is associated with leukocytosis with ' 'lymphopenia, neutrophilia, and elevated levels of <jats:sc>d</jats:sc>-dimer, and C-reactive ' 'protein, ferritin, procalcitonin, and lactate dehydrogenase. The aim of this study was to ' 'describe the clinical and analytical characteristics of hospitalized patients with SARS-CoV-2 ' 'infection and to identify prognostic factors of disease progression.</jats:p>\n' ' </jats:sec>\n' ' <jats:sec id="j_almed-2021-0017_abs_002">\n' ' <jats:title>Methods</jats:title>\n' ' <jats:p>Patients were categorized into two groups based on COVID-19 ' 'severity. Study variables included demographic data, medical history, length of hospital ' 'stay, course of pneumonia, drug therapy, and analytical parameters. A descriptive and ' 'multivariate analysis was performed to identify prognostic factors for disease ' 'severity.</jats:p>\n' ' </jats:sec>\n' ' <jats:sec id="j_almed-2021-0017_abs_003">\n' ' <jats:title>Results</jats:title>\n' ' <jats:p>The study population included 197 patients, of whom 127 had mild ' 'disease and 70 had severe COVID-19. Statistically significant differences were observed in ' 'most analytical parameters. The parameters included in the multivariate analysis were ' 'advanced age and elevated levels of leukocytes, CRP, GGT, and PCT at admission as prognostic ' 'factors for disease severity.</jats:p>\n' ' </jats:sec>\n' ' <jats:sec id="j_almed-2021-0017_abs_004">\n' ' <jats:title>Conclusions</jats:title>\n' ' <jats:p>The prognostic factors for the severity of SARS-CoV-2 infection ' 'identified in this study (age, leukocytes, CRP, GGT, and PCT) will help predict the course of ' 'the disease at an early stage.</jats:p>\n' ' </jats:sec>', 'DOI': '10.1515/almed-2021-0017', 'type': 'journal-article', 'created': {'date-parts': [[2021, 3, 4]], 'date-time': '2021-03-04T12:39:14Z', 'timestamp': 1614861554000}, 'page': '253-258', 'source': 'Crossref', 'is-referenced-by-count': 1, 'title': 'Prognostic factors for the severity of SARS-CoV-2 infection', 'prefix': '10.1515', 'volume': '2', 'author': [ { 'ORCID': 'http://orcid.org/0000-0002-6313-4191', 'authenticated-orcid': False, 'given': 'Ricardo', 'family': 'Rubio-Sánchez', 'sequence': 'first', 'affiliation': [ { 'name': 'Clinical Laboratory , Virgen de Valme University Hospital, South ' 'Health District of Seville , Seville , Spain'}]}, { 'ORCID': 'http://orcid.org/0000-0002-1077-7118', 'authenticated-orcid': False, 'given': 'Esperanza', 'family': 'Lepe-Balsalobre', 'sequence': 'additional', 'affiliation': [ { 'name': 'Clinical Laboratory , Virgen de Valme University Hospital, South ' 'Health District of Seville , Seville , Spain'}]}, { 'given': 'María del Mar', 'family': 'Viloria-Peñas', 'sequence': 'additional', 'affiliation': [ { 'name': 'Clinical Laboratory , Virgen de Valme University Hospital, South ' 'Health District of Seville , Seville , Spain'}]}], 'member': '374', 'published-online': {'date-parts': [[2021, 3, 3]]}, 'reference': [ { 'key': '2023062110051876159_j_almed-2021-0017_ref_001', 'doi-asserted-by': 'crossref', 'unstructured': 'Huang, C, Wang, Y, Li, X, Ren, L, Zhao, J, Hu, Y, et al.. 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