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0 0.5 1 1.5 2+ Symptomatic case 82% Improvement Relative Risk c19hcq.org Rojas-Serrano et al. NCT04318015 HCQ RCT PrEP Favors HCQ Favors control
Hydroxychloroquine For Prophylaxis Of COVID-19 In Health Workers: A Randomized Clinical Trial
Rojas-Serrano et al., medRxiv, doi:10.1101/2021.05.14.21257059 (Preprint), NCT04318015 (history)
16 May 2021    Source   PDF   Share   Tweet
Early terminated HCQ PrEP RCT with 62 HCQ and 65 placebo patients, showing 82% lower cases with treatment, p = 0.12. NCT04318015 (history).
If the trial is continued and the same event rate is observed, statistical significance will be reached after adding about 16 patients per arm.
risk of symptomatic case, 82.0% lower, RR 0.18, p = 0.12, treatment 1 of 62 (1.6%), control 6 of 65 (9.2%), NNT 13, adjusted per study.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Rojas-Serrano et al., 16 May 2021, Double Blind Randomized Controlled Trial, Mexico, preprint, 8 authors, trial NCT04318015 (history).
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