Analgesics
Antiandrogens
Antihistamines
Azvudine
Bromhexine
Budesonide
Colchicine
Conv. Plasma
Curcumin
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Ivermectin
Lifestyle
Melatonin
Metformin
Minerals
Molnupiravir
Monoclonals
Naso/orophar..
Nigella Sativa
Nitazoxanide
PPIs
Paxlovid
Quercetin
Remdesivir
Thermotherapy
Vitamins
More

Other
Feedback
Home
Top
Results
Abstract
All HCQ studies
Meta analysis
 
Feedback
Home
next
study
previous
study
c19hcq.org COVID-19 treatment researchHCQHCQ (more..)
Melatonin Meta
Metformin Meta
Antihistamines Meta
Azvudine Meta Molnupiravir Meta
Bromhexine Meta
Budesonide Meta
Colchicine Meta Nigella Sativa Meta
Conv. Plasma Meta Nitazoxanide Meta
Curcumin Meta PPIs Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   Meta Analysis       

French Multicentre Observational Study on SARS-CoV-2 infections Intensive care initial management: the FRENCH CORONA Study

Roger et al., Anaesthesia Critical Care & Pain Medicine, doi:10.1016/j.accpm.2021.100931
Jul 2021  
  Post
  Facebook
Share
  Source   PDF   All Studies   Meta AnalysisMeta
Mortality 0% Improvement Relative Risk HCQ for COVID-19  Roger et al.  ICU PATIENTS Is very late treatment with HCQ beneficial for COVID-19? Prospective study of 966 patients in France No significant difference in mortality c19hcq.org Roger et al., Anaesthesia Critical Car.., Jul 2021 FavorsHCQ Favorscontrol 0 0.5 1 1.5 2+
HCQ for COVID-19
1st treatment shown to reduce risk in March 2020, now with p < 0.00000000001 from 419 studies, recognized in 46 countries.
No treatment is 100% effective. Protocols combine treatments.
5,100+ studies for 109 treatments. c19hcq.org
Prospective study of 966 ICU patients in France, 289 treated with HCQ, showing no significant difference with treatment. Time based confounding is likely because HCQ became increasingly controversial and less used over the time covered, while overall treatment protocols during this period improved dramatically, i.e., more control patients likely come later in the period when treatment protocols were greatly improved.
This study is excluded in the after exclusion results of meta analysis: substantial confounding by time likely due to declining usage over the early stages of the pandemic when overall treatment protocols improved dramatically.
risk of death, no change, RR 1.00, p = 0.94, treatment 53 of 289 (18.3%), control 120 of 677 (17.7%), odds ratio converted to relative risk.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Roger et al., 10 Jul 2021, prospective, France, peer-reviewed, 34 authors, average treatment delay 8.0 days.
This PaperHCQAll
Abstract: Anaesth Crit Care Pain Med 40 (2021) 100931 Contents lists available at ScienceDirect Anaesthesia Critical Care & Pain Medicine journal homepage: www.elsevier.com Original Article French multicentre observational study on SARS-CoV-2 infections intensive care initial management: the FRENCH CORONA study Claire Roger a,b,*, Olivier Collange c, Myriam Mezzarobba d, Osama Abou-Arab e, Lauranne Teule f, Marc Garnier g, Clément Hoffmann h, Laurent Muller a,b, Jean-Yves Lefrant a,b, Pierre Grégoire Guinot i, Emmanuel Novy j, Paul Abraham k, Thomas Clavier l, Jérémy Bourenne m, Guillaume Besch n, Laurent Favier o, Michel Fiani p, Alexandre Ouattara q, Olivier Joannes-Boyau q, Marc-Olivier Fischer r, Marc Leone s, Younes Ait Tamlihat t, Julien Pottecher u, Pierre-Yves Cordier v, Philippe Aussant w, Mouhamed Djahoum Moussa x, Etienne Hautin y, Marine Bouex z, Jean-Michel Julia aa, Julien Cady bb, Marc Danguy Des Déserts cc, Nicolas Mayeur dd, Thibault Mura d, Bernard Allaouchiche ee, for the AZUREA group a Service des Réanimations, Pôle Anesthésie Réanimation Douleur Urgence, CHU Nıˆmes, Nı̂mes, France UR UM103 IMAGINE, Faculté de Médecine, Univ Montpellier, Montpellier, France c Service d’Anesthésie-Réanimation, Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg, 67000 Strasbourg, France d Department of Biostatistics, Clinical Epidemiology, Public Health, and Innovation in Methodology, CHU Nıˆmes, University Montpellier, Nıˆmes, France e Department of Anaesthesiology and Critical Care Medicine, Amiens Picardie University Hospital, 1 rue du Professeur Christian Cabrol, 80054 Amiens, France f Medical and Surgical Intensive Care Unit, Centre Hospitalier de Perpignan, Perpignan, France g Sorbonne University, GRC29, AP-HP, DMU DREAM, Department of Anaesthesiology and Critical Care Medicine, St Antoine Hospital, Paris, France h Percy Military Teaching Hospital, Burn Centre, France i Anaesthesiology and Critical Care Department, Dijon Bourgogne University Hospital, 2 Bd Maréchal de Lattre de Tassigny, 21000, Dijon, France j Department of Anaesthesiology and Critical Care Medicine, Institut Lorrain du Coeur et des Vaisseaux, University Hospital of Nancy-Brabois, Vandoeuvre-LèsNancy, France k Department of Anaesthesiology and Intensive Care Medicine, Edouard Herriot Hospital, Hospices Civils de Lyon, Lyon, France l Department of Anaesthesiology and Critical Care, Rouen University Hospital, Rouen, France; Normandie Univ, UNIROUEN, Inserm U1096, 76000 Rouen, France m Department of Emergency and Intensive Care Medicine, University Hospital of Marseille, Hôpital de la Timone, Aix Marseille University, Marseille, France n Department of Anaesthesiology and Intensive Care Medicine, University Hospital of Besançon, Besançon, France; University of Franche-Comte, EA3920, Besançon, France o Service de Réanimation Polyvalente, Centre Hospitalier de Béziers, France p Service de Réanimation, CH Château Thierry, France q Service d’Anesthésie-Réanimation Sud, Centre Médico-Chirurgical Magellan, Centre Hospitalier Universitaire (CHU) de Bordeaux, 33000 Bordeaux, France r Department of Anaesthesiology and Critical Care, Normandie Université, UNICAEN, CHU de Caen Normandie, 14000 Caen, France s Department of Anaesthesiology and Intensive Care Medicine, Hôpital Nord, Assistance Publique Hôpitaux de Marseille, Aix Marseille University, 13015, Marseille, France t Service de Réanimation, CH Saintonge, France u Service..
{ 'indexed': {'date-parts': [[2024, 2, 27]], 'date-time': '2024-02-27T10:01:23Z', 'timestamp': 1709028083860}, 'reference-count': 32, 'publisher': 'Elsevier BV', 'issue': '4', 'license': [ { 'start': { 'date-parts': [[2021, 8, 1]], 'date-time': '2021-08-01T00:00:00Z', 'timestamp': 1627776000000}, 'content-version': 'tdm', 'delay-in-days': 0, 'URL': 'https://www.elsevier.com/tdm/userlicense/1.0/'}, { 'start': { 'date-parts': [[2022, 7, 24]], 'date-time': '2022-07-24T00:00:00Z', 'timestamp': 1658620800000}, 'content-version': 'am', 'delay-in-days': 357, 'URL': 'http://www.elsevier.com/open-access/userlicense/1.0/'}], 'funder': [ { 'DOI': '10.13039/501100014262', 'name': 'Société Française d’Anesthésie et de Réanimation', 'doi-asserted-by': 'publisher'}], 'content-domain': { 'domain': [ 'clinicalkey.fr', 'clinicalkey.jp', 'clinicalkey.com.au', 'clinicalkey.es', 'clinicalkey.com', 'elsevier.com', 'sciencedirect.com'], 'crossmark-restriction': True}, 'published-print': {'date-parts': [[2021, 8]]}, 'DOI': '10.1016/j.accpm.2021.100931', 'type': 'journal-article', 'created': {'date-parts': [[2021, 7, 10]], 'date-time': '2021-07-10T15:16:27Z', 'timestamp': 1625930187000}, 'page': '100931', 'update-policy': 'http://dx.doi.org/10.1016/elsevier_cm_policy', 'source': 'Crossref', 'is-referenced-by-count': 18, 'title': 'French multicentre observational study on SARS-CoV-2 infections intensive care initial ' 'management: the FRENCH CORONA study', 'prefix': '10.1016', 'volume': '40', 'author': [ {'given': 'Claire', 'family': 'Roger', 'sequence': 'first', 'affiliation': []}, {'given': 'Olivier', 'family': 'Collange', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0001-5281-6704', 'authenticated-orcid': False, 'given': 'Myriam', 'family': 'Mezzarobba', 'sequence': 'additional', 'affiliation': []}, {'given': 'Osama', 'family': 'Abou-Arab', 'sequence': 'additional', 'affiliation': []}, {'given': 'Lauranne', 'family': 'Teule', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0002-5716-4239', 'authenticated-orcid': False, 'given': 'Marc', 'family': 'Garnier', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0002-3862-7680', 'authenticated-orcid': False, 'given': 'Clément', 'family': 'Hoffmann', 'sequence': 'additional', 'affiliation': []}, {'given': 'Laurent', 'family': 'Muller', 'sequence': 'additional', 'affiliation': []}, {'given': 'Jean-Yves', 'family': 'Lefrant', 'sequence': 'additional', 'affiliation': []}, {'given': 'Pierre Grégoire', 'family': 'Guinot', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0002-4099-8106', 'authenticated-orcid': False, 'given': 'Emmanuel', 'family': 'Novy', 'sequence': 'additional', 'affiliation': []}, {'given': 'Paul', 'family': 'Abraham', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0001-8630-7537', 'authenticated-orcid': False, 'given': 'Thomas', 'family': 'Clavier', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0003-3558-8935', 'authenticated-orcid': False, 'given': 'Jérémy', 'family': 'Bourenne', 'sequence': 'additional', 'affiliation': []}, {'given': 'Guillaume', 'family': 'Besch', 'sequence': 'additional', 'affiliation': []}, {'given': 'Laurent', 'family': 'Favier', 'sequence': 'additional', 'affiliation': []}, {'given': 'Michel', 'family': 'Fiani', 'sequence': 'additional', 'affiliation': []}, {'given': 'Alexandre', 'family': 'Ouattara', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0003-4320-898X', 'authenticated-orcid': False, 'given': 'Olivier', 'family': 'Joannes-Boyau', 'sequence': 'additional', 'affiliation': []}, {'given': 'Marc-Olivier', 'family': 'Fischer', 'sequence': 'additional', 'affiliation': []}, {'given': 'Marc', 'family': 'Leone', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0002-2791-3868', 'authenticated-orcid': False, 'given': 'Younes', 'family': 'Ait Tamlihat', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0001-6073-4354', 'authenticated-orcid': False, 'given': 'Julien', 'family': 'Pottecher', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0002-8756-9667', 'authenticated-orcid': False, 'given': 'Pierre-Yves', 'family': 'Cordier', 'sequence': 'additional', 'affiliation': []}, {'given': 'Philippe', 'family': 'Aussant', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0003-3189-8119', 'authenticated-orcid': False, 'given': 'Mouhamed Djahoum', 'family': 'Moussa', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0002-7133-3529', 'authenticated-orcid': False, 'given': 'Etienne', 'family': 'Hautin', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0003-4626-8582', 'authenticated-orcid': False, 'given': 'Marine', 'family': 'Bouex', 'sequence': 'additional', 'affiliation': []}, {'given': 'Jean-Michel', 'family': 'Julia', 'sequence': 'additional', 'affiliation': []}, {'given': 'Julien', 'family': 'Cady', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0002-0185-9955', 'authenticated-orcid': False, 'given': 'Marc', 'family': 'Danguy Des Déserts', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0002-7140-2547', 'authenticated-orcid': False, 'given': 'Nicolas', 'family': 'Mayeur', 'sequence': 'additional', 'affiliation': []}, {'given': 'Thibault', 'family': 'Mura', 'sequence': 'additional', 'affiliation': []}, {'given': 'Bernard', 'family': 'Allaouchiche', 'sequence': 'additional', 'affiliation': []}], 'member': '78', 'reference': [ { 'issue': '7', 'key': '10.1016/j.accpm.2021.100931_bib0005', 'doi-asserted-by': 'crossref', 'first-page': '1303', 'DOI': '10.1007/s00134-020-06092-5', 'article-title': 'Managing ICU surge during the COVID-19 crisis: rapid guidelines', 'volume': '46', 'author': 'Aziz', 'year': '2020', 'journal-title': 'Intensive Care Med'}, { 'issue': '6', 'key': '10.1016/j.accpm.2021.100931_bib0010', 'doi-asserted-by': 'crossref', 'first-page': '1099', 'DOI': '10.1007/s00134-020-06033-2', 'article-title': 'COVID-19 pneumonia: different respiratory treatments for different ' 'phenotypes?', 'volume': '46', 'author': 'Gattinoni', 'year': '2020', 'journal-title': 'Intensive Care Med'}, { 'key': '10.1016/j.accpm.2021.100931_bib0015', 'doi-asserted-by': 'crossref', 'first-page': '2385', 'DOI': '10.1007/s00134-020-06306-w', 'article-title': 'Prone position in ARDS patients: why, when, how and for whom', 'volume': '46', 'author': 'Guerin', 'year': '2020', 'journal-title': 'Intensive Care Med'}, { 'key': '10.1016/j.accpm.2021.100931_bib0020', 'first-page': '693', 'article-title': 'Dexamethasone in hospitalized patients with Covid-19 - preliminary ' 'report', 'volume': '384', 'author': 'Group', 'year': '2020', 'journal-title': 'N Engl J Med'}, { 'issue': '10285', 'key': '10.1016/j.accpm.2021.100931_bib0025', 'doi-asserted-by': 'crossref', 'first-page': '1637', 'DOI': '10.1016/S0140-6736(21)00676-0', 'article-title': 'Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): ' 'a randomised, controlled, open-label, platform trial', 'volume': '397', 'author': 'Group', 'year': '2021', 'journal-title': 'Lancet'}, { 'issue': '13', 'key': '10.1016/j.accpm.2021.100931_bib0030', 'doi-asserted-by': 'crossref', 'first-page': '1330', 'DOI': '10.1001/jama.2020.17023', 'article-title': 'Association between administration of systemic corticosteroids and ' 'mortality among critically Ill patients with COVID-19: a meta-analysis', 'volume': '324', 'author': 'Group WHOREAfC-TW', 'year': '2020', 'journal-title': 'JAMA'}, { 'issue': '10223', 'key': '10.1016/j.accpm.2021.100931_bib0035', 'doi-asserted-by': 'crossref', 'first-page': '497', 'DOI': '10.1016/S0140-6736(20)30183-5', 'article-title': 'Clinical features of patients infected with 2019 novel coronavirus in ' 'Wuhan, China', 'volume': '395', 'author': 'Huang', 'year': '2020', 'journal-title': 'Lancet'}, { 'key': '10.1016/j.accpm.2021.100931_bib0040', 'doi-asserted-by': 'crossref', 'first-page': '2200', 'DOI': '10.1007/s00134-020-06192-2', 'article-title': 'Clinical features, ventilatory management, and outcome of ARDS caused ' 'by COVID-19 are similar to other causes of ARDS', 'volume': '46', 'author': 'Ferrando', 'year': '2020', 'journal-title': 'Intensive Care Med'}, { 'issue': '10', 'key': '10.1016/j.accpm.2021.100931_bib0045', 'doi-asserted-by': 'crossref', 'first-page': '1863', 'DOI': '10.1007/s00134-020-06211-2', 'article-title': 'Clinical characteristics and outcomes of critically ill patients with ' 'novel coronavirus infectious disease (COVID-19) in China: a ' 'retrospective multicenter study', 'volume': '46', 'author': 'Xie', 'year': '2020', 'journal-title': 'Intensive Care Med'}, { 'issue': '10', 'key': '10.1016/j.accpm.2021.100931_bib0050', 'doi-asserted-by': 'crossref', 'first-page': '1345', 'DOI': '10.1001/jamainternmed.2020.3539', 'article-title': 'Risk factors associated with mortality among patients with COVID-19 in ' 'intensive care units in Lombardy, Italy', 'volume': '180', 'author': 'Grasselli', 'year': '2020', 'journal-title': 'JAMA Intern Med'}, { 'issue': '8', 'key': '10.1016/j.accpm.2021.100931_bib0055', 'doi-asserted-by': 'crossref', 'first-page': '782', 'DOI': '10.1001/jama.2020.12839', 'article-title': 'Pathophysiology, transmission, diagnosis, and treatment of coronavirus ' 'disease 2019 (COVID-19): a review', 'volume': '324', 'author': 'Wiersinga', 'year': '2020', 'journal-title': 'JAMA'}, { 'issue': '9596', 'key': '10.1016/j.accpm.2021.100931_bib0060', 'doi-asserted-by': 'crossref', 'first-page': '1453', 'DOI': '10.1016/S0140-6736(07)61602-X', 'article-title': 'The strengthening the Reporting of Observational Studies in ' 'Epidemiology (STROBE) statement: guidelines for reporting observational ' 'studies', 'volume': '370', 'author': 'von Elm', 'year': '2007', 'journal-title': 'Lancet'}, { 'key': '10.1016/j.accpm.2021.100931_bib0065', 'doi-asserted-by': 'crossref', 'first-page': '883', 'DOI': '10.1016/j.accpm.2020.10.012', 'article-title': 'French legal approach to patient consent in clinical research', 'volume': '39', 'author': 'Toulouse', 'year': '2020', 'journal-title': 'Anaesth Crit Care Pain Med'}, { 'issue': '5', 'key': '10.1016/j.accpm.2021.100931_bib0070', 'doi-asserted-by': 'crossref', 'first-page': '373', 'DOI': '10.1016/0021-9681(87)90171-8', 'article-title': 'A new method of classifying prognostic comorbidity in longitudinal ' 'studies: development and validation', 'volume': '40', 'author': 'Charlson', 'year': '1987', 'journal-title': 'J Chronic Dis'}, { 'issue': '24', 'key': '10.1016/j.accpm.2021.100931_bib0075', 'doi-asserted-by': 'crossref', 'first-page': '2957', 'DOI': '10.1001/jama.1993.03510240069035', 'article-title': 'A new simplified acute physiology score (SAPS II) based on a ' 'European/North American multicenter study', 'volume': '270', 'author': 'Le Gall', 'year': '1993', 'journal-title': 'JAMA'}, { 'issue': '21', 'key': '10.1016/j.accpm.2021.100931_bib0080', 'doi-asserted-by': 'crossref', 'first-page': '2323', 'DOI': '10.1001/jama.2009.1754', 'article-title': 'International study of the prevalence and outcomes of infection in ' 'intensive care units', 'volume': '302', 'author': 'Vincent', 'year': '2009', 'journal-title': 'JAMA'}, { 'issue': '1', 'key': '10.1016/j.accpm.2021.100931_bib0085', 'doi-asserted-by': 'crossref', 'first-page': '83', 'DOI': '10.1016/j.accpm.2017.11.006', 'article-title': 'Hospital-acquired pneumonia in ICU', 'volume': '37', 'author': 'Leone', 'year': '2018', 'journal-title': 'Anaesth Crit Care Pain Med'}, { 'issue': '23', 'key': '10.1016/j.accpm.2021.100931_bib0090', 'first-page': '2526', 'article-title': 'Acute respiratory distress syndrome: the Berlin Definition', 'volume': '307', 'author': 'Force', 'year': '2012', 'journal-title': 'JAMA'}, { 'key': '10.1016/j.accpm.2021.100931_bib0095', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.jbi.2019.103208', 'article-title': 'The REDCap consortium: building an international community of software ' 'platform partners', 'volume': '95', 'author': 'Harris', 'year': '2019', 'journal-title': 'J Biomed Inform'}, { 'issue': '1', 'key': '10.1016/j.accpm.2021.100931_bib0100', 'doi-asserted-by': 'crossref', 'first-page': '60', 'DOI': '10.1007/s00134-020-06294-x', 'article-title': 'Clinical characteristics and day-90 outcomes of 4244 critically ill ' 'adults with COVID-19: a prospective cohort study', 'volume': '47', 'author': 'Network C-IGobotR, the C-ICUI', 'year': '2021', 'journal-title': 'Intensive Care Med'}, { 'issue': '5', 'key': '10.1016/j.accpm.2021.100931_bib0105', 'doi-asserted-by': 'crossref', 'first-page': '854', 'DOI': '10.1007/s00134-020-06022-5', 'article-title': 'Surviving Sepsis Campaign: guidelines on the management of critically ' 'ill adults with coronavirus disease 2019 (COVID-19)', 'volume': '46', 'author': 'Alhazzani', 'year': '2020', 'journal-title': 'Intensive Care Med'}, { 'issue': '6', 'key': '10.1016/j.accpm.2021.100931_bib0110', 'doi-asserted-by': 'crossref', 'first-page': '1092', 'DOI': '10.1097/TA.0000000000002939', 'article-title': 'Timing of invasive mechanic ventilation in critically ill patients with ' 'coronavirus disease 2019', 'volume': '89', 'author': 'Zhang', 'year': '2020', 'journal-title': 'J Trauma Acute Care Surg'}, { 'issue': '1', 'key': '10.1016/j.accpm.2021.100931_bib0115', 'doi-asserted-by': 'crossref', 'first-page': '121', 'DOI': '10.1186/s13054-021-03540-6', 'article-title': 'Effect of timing of intubation on clinical outcomes of critically ill ' 'patients with COVID-19: a systematic review and meta-analysis of ' 'non-randomized cohort studies', 'volume': '25', 'author': 'Papoutsi', 'year': '2021', 'journal-title': 'Crit Care'}, { 'issue': '9', 'key': '10.1016/j.accpm.2021.100931_bib0120', 'doi-asserted-by': 'crossref', 'DOI': '10.3390/jcm9092847', 'article-title': 'Clinical significance of timing of intubation in critically ill ' 'patients with COVID-19: a multi-center retrospective study', 'volume': '9', 'author': 'Lee', 'year': '2020', 'journal-title': 'J Clin Med'}, { 'key': '10.1016/j.accpm.2021.100931_bib0125', 'doi-asserted-by': 'crossref', 'first-page': '538', 'DOI': '10.1007/s00134-021-06388-0', 'article-title': 'Evolving changes in mortality of 13,301 critically ill adult patients ' 'with COVID-19 over 8 months', 'volume': '47', 'author': 'Kurtz', 'year': '2021', 'journal-title': 'Intensive Care Med'}, { 'issue': '2', 'key': '10.1016/j.accpm.2021.100931_bib0130', 'doi-asserted-by': 'crossref', 'first-page': '188', 'DOI': '10.1007/s00134-020-06323-9', 'article-title': 'Relationship between SARS-CoV-2 infection and the incidence of ' 'ventilator-associated lower respiratory tract infections: a European ' 'multicenter cohort study', 'volume': '47', 'author': 'Rouze', 'year': '2021', 'journal-title': 'Intensive Care Med'}, { 'key': '10.1016/j.accpm.2021.100931_bib0135', 'first-page': '60', 'article-title': 'Clinical characteristics and day-90 outcomes of 4244 critically ill ' 'adults with COVID-19: a prospective cohort study', 'volume': '47', 'author': 'Network C-IGobotR, the C-ICUI', 'year': '2020', 'journal-title': 'Intensive Care Med'}, { 'issue': '1', 'key': '10.1016/j.accpm.2021.100931_bib0140', 'doi-asserted-by': 'crossref', 'first-page': '285', 'DOI': '10.1186/s13054-020-03006-1', 'article-title': 'Mortality rates of patients with COVID-19 in the intensive care unit: a ' 'systematic review of the emerging literature', 'volume': '24', 'author': 'Quah', 'year': '2020', 'journal-title': 'Crit Care'}, { 'issue': '8', 'key': '10.1016/j.accpm.2021.100931_bib0145', 'doi-asserted-by': 'crossref', 'first-page': '693', 'DOI': '10.1056/NEJMoa2021436', 'article-title': 'Dexamethasone in hospitalized patients with Covid-19', 'volume': '384', 'author': 'Group', 'year': '2021', 'journal-title': 'N Engl J Med'}, { 'issue': '5', 'key': '10.1016/j.accpm.2021.100931_bib0150', 'doi-asserted-by': 'crossref', 'DOI': '10.1183/13993003.01112-2020', 'article-title': 'Association between age and clinical characteristics and outcomes of ' 'COVID-19', 'volume': '55', 'author': 'Liu', 'year': '2020', 'journal-title': 'Eur Respir J'}, { 'key': '10.1016/j.accpm.2021.100931_bib0155', 'doi-asserted-by': 'crossref', 'first-page': '710', 'DOI': '10.1007/s00134-021-06399-x', 'article-title': 'Long-term mortality of elderly patients after intensive care unit ' 'admission for COVID-19', 'volume': '47', 'author': 'Guillon', 'year': '2021', 'journal-title': 'Intensive Care Med'}, { 'issue': '2', 'key': '10.1016/j.accpm.2021.100931_bib0160', 'doi-asserted-by': 'crossref', 'first-page': 'R31', 'DOI': '10.1186/cc5713', 'article-title': 'Acute Kidney Injury Network: report of an initiative to improve ' 'outcomes in acute kidney injury', 'volume': '11', 'author': 'Mehta', 'year': '2007', 'journal-title': 'Crit Care'}], 'container-title': 'Anaesthesia Critical Care &amp; Pain Medicine', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://api.elsevier.com/content/article/PII:S2352556821001351?httpAccept=text/xml', 'content-type': 'text/xml', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://api.elsevier.com/content/article/PII:S2352556821001351?httpAccept=text/plain', 'content-type': 'text/plain', 'content-version': 'vor', 'intended-application': 'text-mining'}], 'deposited': { 'date-parts': [[2022, 7, 22]], 'date-time': '2022-07-22T23:27:27Z', 'timestamp': 1658532447000}, 'score': 1, 'resource': {'primary': {'URL': 'https://linkinghub.elsevier.com/retrieve/pii/S2352556821001351'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2021, 8]]}, 'references-count': 32, 'journal-issue': {'issue': '4', 'published-print': {'date-parts': [[2021, 8]]}}, 'alternative-id': ['S2352556821001351'], 'URL': 'http://dx.doi.org/10.1016/j.accpm.2021.100931', 'relation': {}, 'ISSN': ['2352-5568'], 'subject': [ 'Anesthesiology and Pain Medicine', 'Critical Care and Intensive Care Medicine', 'General Medicine'], 'container-title-short': 'Anaesthesia Critical Care &amp; Pain Medicine', 'published': {'date-parts': [[2021, 8]]}, 'assertion': [ {'value': 'Elsevier', 'name': 'publisher', 'label': 'This article is maintained by'}, { 'value': 'French multicentre observational study on SARS-CoV-2 infections intensive care ' 'initial management: the FRENCH CORONA study', 'name': 'articletitle', 'label': 'Article Title'}, { 'value': 'Anaesthesia Critical Care & Pain Medicine', 'name': 'journaltitle', 'label': 'Journal Title'}, { 'value': 'https://doi.org/10.1016/j.accpm.2021.100931', 'name': 'articlelink', 'label': 'CrossRef DOI link to publisher maintained version'}, {'value': 'article', 'name': 'content_type', 'label': 'Content Type'}, { 'value': "© 2021 Société française d'anesthésie et de réanimation (Sfar). Published by " 'Elsevier Masson SAS. All rights reserved.', 'name': 'copyright', 'label': 'Copyright'}], 'article-number': '100931'}
Late treatment
is less effective
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit