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French Multicentre Observational Study on SARS-CoV-2 infections Intensive care initial management: the FRENCH CORONA Study

Roger et al., Anaesthesia Critical Care & Pain Medicine, doi:10.1016/j.accpm.2021.100931
Jul 2021  
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Mortality 0% Improvement Relative Risk HCQ for COVID-19  Roger et al.  ICU PATIENTS Is very late treatment with HCQ beneficial for COVID-19? Prospective study of 966 patients in France No significant difference in mortality Roger et al., Anaesthesia Critical Car.., Jul 2021 FavorsHCQ Favorscontrol 0 0.5 1 1.5 2+
HCQ for COVID-19
1st treatment shown to reduce risk in March 2020
*, now with p < 0.00000000001 from 411 studies, recognized in 46 countries.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,300+ studies for 75 treatments.
Prospective study of 966 ICU patients in France, 289 treated with HCQ, showing no significant difference with treatment. Time based confounding is likely because HCQ became increasingly controversial and less used over the time covered, while overall treatment protocols during this period improved dramatically, i.e., more control patients likely come later in the period when treatment protocols were greatly improved.
This study is excluded in the after exclusion results of meta analysis: substantial confounding by time likely due to declining usage over the early stages of the pandemic when overall treatment protocols improved dramatically.
risk of death, no change, RR 1.00, p = 0.94, treatment 53 of 289 (18.3%), control 120 of 677 (17.7%), odds ratio converted to relative risk.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Roger et al., 10 Jul 2021, prospective, France, peer-reviewed, 34 authors, average treatment delay 8.0 days.
This PaperHCQAll
Abstract: Anaesth Crit Care Pain Med 40 (2021) 100931 Contents lists available at ScienceDirect Anaesthesia Critical Care & Pain Medicine journal homepage: Original Article French multicentre observational study on SARS-CoV-2 infections intensive care initial management: the FRENCH CORONA study Claire Roger a,b,*, Olivier Collange c, Myriam Mezzarobba d, Osama Abou-Arab e, Lauranne Teule f, Marc Garnier g, Clément Hoffmann h, Laurent Muller a,b, Jean-Yves Lefrant a,b, Pierre Grégoire Guinot i, Emmanuel Novy j, Paul Abraham k, Thomas Clavier l, Jérémy Bourenne m, Guillaume Besch n, Laurent Favier o, Michel Fiani p, Alexandre Ouattara q, Olivier Joannes-Boyau q, Marc-Olivier Fischer r, Marc Leone s, Younes Ait Tamlihat t, Julien Pottecher u, Pierre-Yves Cordier v, Philippe Aussant w, Mouhamed Djahoum Moussa x, Etienne Hautin y, Marine Bouex z, Jean-Michel Julia aa, Julien Cady bb, Marc Danguy Des Déserts cc, Nicolas Mayeur dd, Thibault Mura d, Bernard Allaouchiche ee, for the AZUREA group a Service des Réanimations, Pôle Anesthésie Réanimation Douleur Urgence, CHU Nıˆmes, Nı̂mes, France UR UM103 IMAGINE, Faculté de Médecine, Univ Montpellier, Montpellier, France c Service d’Anesthésie-Réanimation, Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg, 67000 Strasbourg, France d Department of Biostatistics, Clinical Epidemiology, Public Health, and Innovation in Methodology, CHU Nıˆmes, University Montpellier, Nıˆmes, France e Department of Anaesthesiology and Critical Care Medicine, Amiens Picardie University Hospital, 1 rue du Professeur Christian Cabrol, 80054 Amiens, France f Medical and Surgical Intensive Care Unit, Centre Hospitalier de Perpignan, Perpignan, France g Sorbonne University, GRC29, AP-HP, DMU DREAM, Department of Anaesthesiology and Critical Care Medicine, St Antoine Hospital, Paris, France h Percy Military Teaching Hospital, Burn Centre, France i Anaesthesiology and Critical Care Department, Dijon Bourgogne University Hospital, 2 Bd Maréchal de Lattre de Tassigny, 21000, Dijon, France j Department of Anaesthesiology and Critical Care Medicine, Institut Lorrain du Coeur et des Vaisseaux, University Hospital of Nancy-Brabois, Vandoeuvre-LèsNancy, France k Department of Anaesthesiology and Intensive Care Medicine, Edouard Herriot Hospital, Hospices Civils de Lyon, Lyon, France l Department of Anaesthesiology and Critical Care, Rouen University Hospital, Rouen, France; Normandie Univ, UNIROUEN, Inserm U1096, 76000 Rouen, France m Department of Emergency and Intensive Care Medicine, University Hospital of Marseille, Hôpital de la Timone, Aix Marseille University, Marseille, France n Department of Anaesthesiology and Intensive Care Medicine, University Hospital of Besançon, Besançon, France; University of Franche-Comte, EA3920, Besançon, France o Service de Réanimation Polyvalente, Centre Hospitalier de Béziers, France p Service de Réanimation, CH Château Thierry, France q Service d’Anesthésie-Réanimation Sud, Centre Médico-Chirurgical Magellan, Centre Hospitalier Universitaire (CHU) de Bordeaux, 33000 Bordeaux, France r Department of Anaesthesiology and Critical Care, Normandie Université, UNICAEN, CHU de Caen Normandie, 14000 Caen, France s Department of Anaesthesiology and Intensive Care Medicine, Hôpital Nord, Assistance Publique Hôpitaux de Marseille, Aix Marseille University, 13015, Marseille, France t Service de Réanimation, CH Saintonge, France u Service..
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Late treatment
is less effective
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