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0 0.5 1 1.5 2+ Mortality -6% Improvement Relative Risk HCQ  Rodriguez-Nava et al.  LATE TREATMENT Is late treatment with HCQ beneficial for COVID-19? Retrospective 313 patients in the USA No significant difference in mortality Rodriguez-Nava et al., Mayo Clinic Pro.., Nov 2020 Favors HCQ Favors control

Clinical characteristics and risk factors for mortality of hospitalized patients with COVID-19 in a community hospital: A retrospective cohort study

Rodriguez-Nava et al., Mayo Clinic Proceedings: Innovations, Quality & Outcomes
Nov 2020  
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Retrospective 313 patients, mostly critical stage and mostly requiring respiratory support, showing unadjusted RR 1.06, p = 0.77. Confounding by indication likely. This study is excluded in the after exclusion results of meta analysis: substantial unadjusted confounding by indication likely; excessive unadjusted differences between groups; unadjusted results with no group details.
This study includes colchicine and HCQ.
risk of death, 6.3% higher, RR 1.06, p = 0.77, treatment 22 of 65 (33.8%), control 79 of 248 (31.9%), unadjusted.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Rodriguez-Nava et al., 5 Nov 2020, retrospective, USA, peer-reviewed, median age 68.0, 8 authors.
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Clinical Characteristics and Risk Factors for Death of Hospitalized Patients With COVID-19 in a Community Hospital: A Retrospective Cohort Study
MD Guillermo Rodriguez-Nava, MD; Daniela Maria Adriana Yanez-Bello, Daniela Patricia Trelles-Garcia, Chul Won Chung, MD Sana Chaudry, MD Aimen S Khan, MD, FACP Harvey J Friedman, MD David W Hines
Mayo Clinic Proceedings: Innovations, Quality & Outcomes, doi:10.1016/j.mayocpiqo.2020.10.007
Objective: To describe the clinical characteristics, outcomes, and risk factors for death of patients with coronavirus disease 2019 (COVID-19) in a community hospital setting. Patients and Methods: This single-center retrospective cohort study included 313 adult patients with laboratory-confirmed COVID-19 admitted to a community hospital in Cook County, Illinois, from March 1, 2020, to May 25, 2020. Demographics, medical history, underlying comorbidities, symptoms, signs, laboratory findings, imaging studies, management, and progression to discharge or death data were collected and analyzed. Results: Of 313 patients, the median age was 68 years (interquartile range, 59.0-78.5 years; range, 19-98 years), 182 (58.1%) were male, 119 (38%) were white, and 194 (62%) were admitted from a long-term care facility (LTCF). As of May 25, 2020, there were 212 (67.7%) survivors identified, whereas 101 (32.3%) nonsurvivors were identified. Multivariable Cox regression analysis showed increasing hazards of inpatient death associated with older age (hazard ratio [HR] 1.02; 95% CI, 1.01-1.04), LTCF residence (HR, 3.23; 95% CI, 1.68-6.20), and quick Sequential Organ Failure Assessment scores (HR, 2.59; 95% CI, 1.78-3.76). Conclusion: In this single-center retrospective cohort study of 313 adult patients hospitalized with COVID-19 illness in a community hospital in Cook County, Illinois, older patients, LTCF residents, and patients with high quick Sequential Organ Failure Assessment scores were found to have worse clinical outcomes and increased risk of death.
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Late treatment
is less effective
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