Abstract: ORIGINAL ARTICLE Clinical Characteristics and Risk Factors for Death of Hospitalized Patients With COVID19 in a Community Hospital: A Retrospective Cohort Study Guillermo Rodriguez-Nava, MD; Maria Adriana Yanez-Bello, MD; Daniela Patricia Trelles-Garcia, MD; Chul Won Chung, MD; Sana Chaudry, MD; Aimen S. Khan, MD; Harvey J. Friedman, MD, FACP; and David W. Hines, MD Abstract Objective: To describe the clinical characteristics, outcomes, and risk factors for death of patients with coronavirus disease 2019 (COVID-19) in a community hospital setting. Patients and Methods: This single-center retrospective cohort study included 313 adult patients with laboratory-confirmed COVID-19 admitted to a community hospital in Cook County, Illinois, from March 1, 2020, to May 25, 2020. Demographics, medical history, underlying comorbidities, symptoms, signs, laboratory findings, imaging studies, management, and progression to discharge or death data were collected and analyzed. Results: Of 313 patients, the median age was 68 years (interquartile range, 59.0-78.5 years; range, 19-98 years), 182 (58.1%) were male, 119 (38%) were white, and 194 (62%) were admitted from a long-term care facility (LTCF). As of May 25, 2020, there were 212 (67.7%) survivors identified, whereas 101 (32.3%) nonsurvivors were identified. Multivariable Cox regression analysis showed increasing hazards of inpatient death associated with older age (hazard ratio [HR] 1.02; 95% CI, 1.01-1.04), LTCF residence (HR, 3.23; 95% CI, 1.68-6.20), and quick Sequential Organ Failure Assessment scores (HR, 2.59; 95% CI, 1.78-3.76). Conclusion: In this single-center retrospective cohort study of 313 adult patients hospitalized with COVID-19 illness in a community hospital in Cook County, Illinois, older patients, LTCF residents, and patients with high quick Sequential Organ Failure Assessment scores were found to have worse clinical outcomes and increased risk of death. ª 2020 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/) n Mayo Clin Proc Inn Qual Out 2021;5(1):1-10 O n December 31, 2019, the World Health Organization received a report of a cluster of cases of pneumonia of unknown etiology detected in Wuhan City, Hubei Province of China.1 The pathogen was identified as a novel enveloped RNA betacoronavirus, different from both Middle East respiratory syndrome coronavirus and severe acute respiratory syndrome coronavirus, later designated severe acute respiratory syndrome coronavirus 2.2 The disease that it causes was later named coronavirus disease 2019 (COVID-19).3 This new disease rapidly spread globally, prompting the World Health Organization to declare it a pandemic on March 11, 2020. The United States has been, to date, the country with the highest incidence of the disease. As of June 2, 2020, there had been a total of 1,802,470 cases reported in the United States; in Cook County, Illinois, there had been 78,495 confirmed cases.4,5 After the emergence of this novel pathogen, several cohort and case series studies have described COVID-19 in populations overseas and large US academic centers.6-17 Ecologic studies have found significant differences within the US territory regarding mortality patterns as a function of geographic location and population composition.18 Also, detailed data on demographic characteristics, comorbidities, risk factors, and..