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All Studies   Meta Analysis    Recent:   

COVID-19 in hospitalized patients in Spain: a cohort study in Madrid

Rodriguez-Gonzalez et al., International Journal of Antimicrobial Agents, doi:10.1016/j.ijantimicag.2020.106249
Nov 2020  
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Mortality 23% Improvement Relative Risk HCQ  Rodriguez-Gonzalez et al.  LATE TREATMENT Is late treatment with HCQ beneficial for COVID-19? Retrospective 1,208 patients in Spain Lower mortality with HCQ (not stat. sig., p=0.26) c19hcq.org Rodriguez-Gonzalez et al., Int. J. Ant.., Nov 2020 FavorsHCQ Favorscontrol 0 0.5 1 1.5 2+
HCQ for COVID-19
1st treatment shown to reduce risk in March 2020
 
*, now with p < 0.00000000001 from 411 studies, recognized in 46 countries.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,300+ studies for 75 treatments. c19hcq.org
Retrospective 1255 patients in Spain showing lower mortality with HCQ. Subject to confounding by indication.
Although the 23% lower mortality is not statistically significant, it is consistent with the significant 26% lower mortality [22‑30%] from meta analysis of the 249 mortality results to date.
risk of death, 22.8% lower, RR 0.77, p = 0.26, treatment 251 of 1,148 (21.9%), control 17 of 60 (28.3%), NNT 15.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Rodriguez-Gonzalez et al., 28 Nov 2020, retrospective, Spain, peer-reviewed, 20 authors, average treatment delay 6.0 days.
This PaperHCQAll
COVID-19 in hospitalised patients in Spain: a cohort study in Madrid
Carmen Guadalupe Rodriguez-Gonzalez, Esther Chamorro-De-Vega, Maricela Valerio, Miguel Angel Amor-Garcia, Francisco Tejerina, Milagros Sancho-Gonzalez, Alvaro Narrillos-Moraza, Alvaro Gimenez-Manzorro, Silvia Manrique-Rodriguez, Marina Machado, Maria Olmedo, Vicente Escudero-Vilaplana, Cristina Villanueva-Bueno, Beatriz Torroba-Sanz, Alejandra Melgarejo-Ortuño, Juan Vicente-Valor, Ana Herranz, Emilio Bouza, Patricia Muñoz, Maria Sanjurjo
International Journal of Antimicrobial Agents, doi:10.1016/j.ijantimicag.2020.106249
Few large series describe the clinical characteristics, outcomes and costs of COVID-19 in Western countries. This cohort reports the first 1255 adult cases receiving anti-COVID-19 treatment at a Spanish hospital (1-24 March 2020). Treatment costs were calculated. A logistic regression model was used to explore risk factors on admission associated with ARDS. A bivariate Cox proportional hazard ratio (HR) model was employed to determine the HR between individual factors and death. We included 1255 patients (median age 65 years; 57.8% male), of which 92.3% required hospitalisation. The prevalence of hypertension, cardiovascular disease and diabetes mellitus (DM) was 45.1%, 31.4% and 19.9%, respectively. Lymphocytopenia (54.8%), elevated alanine aminotransferase (33.0%) and elevated lactate dehydrogenase (58.5%) were frequent. Overall, 36.7% of patients developed ARDS, 10.0% were admitted to an ICU and 21.3% died. The most frequent antiviral combinations were lopinavir/ritonavir plus hydroxychloroquine (44.2%), followed by triple therapy with interferon beta-1b (32.7%). Corticosteroids and tocilizumab were used in 25.3% and 12.9% of patients, respectively. Total cost of anti-COVID-19 agents was €511 825 ( €408/patient). By multivariate analysis, risk factors associated with ARDS included older age, obesity, DM, severe hypoxaemia, lymphocytopenia, increased creatine kinase and increased C-reactive protein. In multivariate Cox model, older age (HR 1.07, 95% CI 1.06-1.09), cardiovascular disease (HR 1.34, 95% CI 1.01-1.79), DM (HR 1.45, 95% CI 1.09-1.92), severe hypoxaemia (HR 2.01, 95% CI 1.49-2.72), lymphocytopenia (HR 1.62, 95% CI 1.20-2.20) and increased C-reactive protein (HR 1.04, 95% CI 1.02-1.06) were risk factors for mortality.
Supplementary materials Supplementary material associated with this article can be found, in the online version, at doi: 10.1016/j.ijantimicag.2020. 106249 .
References
Armstrong, Kane, Cook, Outcomes from intensive care in patients with COVID-19: a systematic review and meta-analysis of observational studies, Anaesthesia, doi:10.1111/anae.15201
Cao, Wang, Wen, Liu, Wang et al., A trial of lopinavir-ritonavir in adults hospitalized with severe Covid-19, N Engl J Med, doi:10.1056/NEJMoa2001282
Docherty, Harrison, Green, Hardwick, Pius et al., Features of 20 133 UK patients in hospital with COVID-19 using the IS-ARIC WHO Clinical Characterisation Protocol: prospective observational cohort study, BMJ, doi:10.1136/bmj.m1985
Giacomelli, Ridolfo, Milazzo, Oreni, Bernacchia et al., 30-day mortality in patients hospitalized with COVID-19 during the first wave of the Italian epidemic: a prospective cohort study, Pharmacol Res, doi:10.1016/j.phrs.2020.104931
Grasselli, Zangrillo, Zanella, Antonelli, Cabrini et al., Baseline characteristics and outcomes of 1591 patients infected with SARS-CoV-2 admitted to ICUs of the Lombardy Region. Italy, JAMA, doi:10.1001/jama.2020.5394
Guan, Ni, Hu, Liang, Ou et al., Clinical characteristics of coronavirus disease 2019 in China, N Engl J Med, doi:10.1056/NEJMoa2002032
Richardson, Hirsch, Narasimhan, Crawford, Mcginn et al., Presenting characteristics, comorbidities, and outcomes among 5700 patients hospitalized with COVID-19 in the New York City area, JAMA, doi:10.1001/jama.2020.6775
Wu, Chen, Cai, Xia, Zhou et al., Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 pneumonia in Wuhan, China, JAMA Intern Med, doi:10.1001/jamainternmed.2020.0994
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Late treatment
is less effective
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