Severe infection due to the SARS-CoV-2 coronavirus: Experience of a tertiary hospital with COVID-19 patients during the 2020 pandemic ଝ
Objective: To describe the clinical and respiratory characteristics of a cohort of 43 patients with COVID-19 after an evolutive period of 28 days. Design: A prospective, single-center observational study was carried out. Setting: Intensive care. Patients: Patients admitted due to COVID-19 and respiratory failure. Interventions: None. Variables: Automatic recording was made of demographic variables, severity parameters, laboratory data, assisted ventilation (HFO: high-flow oxygen therapy and IMV: invasive mechanical ventilation), oxygenation (PaO2, PaO2/FiO2) and complications. The patients were divided into three groups: survivors (G1), deceased (G2) and patients remaining under admission (G3). The chi-squared test or Fisher exact test (categorical variables) was used, along with the Mann-Whitney U-test or Wilcoxon test for analyzing the differences between medians. Statistical significance was considered for p < 0.05.
Authorship Study conception and design: AR, MB, LC, GM, RC, and ST. Data acquisition and analysis: AR, MB, JG, GM, RC, EPP, ST, CBB, RSP, LC and XT. Data interpretation: AR, MB, LC, GM, RC, ESP, LC, ESP and EPP. Important intellectual contribution to the contents of the study: AR, MB, GM, RC, ESP, LC, and LC. Drafting of the manuscript: AR, MB, GM, and RC. Critical review of the contents of the article: JG, EPP, CBB, RSP, ST and XT. All the authors approved the final manuscript submitted for evaluation and possible publication.
Conflicts of interest The authors declare that they have no conflicts of interest in relation to the present article. AR has received a research grant from Gilead Science for the study of nebulized antibiotics, and has received fees for teaching conferences from Biomerieux, Astellas, Pfizer, Thermo Fisher, MSD, Gilead, Shionogi and BRHAMS. There are no conflicts of interest in relation to the present study, however. The rest of the authors have no conflicts of interest.
Appendix A. List of research members of the HJ23-COVID-19 Working Group
Clinical laboratory Natalia Bastón-Paz, Carolina Sarvisé-Buil, Frederic Gómez-Bertomeu, Gemma Recio-Comi, Carla Martin-Grau, Silvia Montolio-Breva, Victoria Rivera-Moreno, Modest Sabaté-Piñol, Carmen Molina-Clavero, Nuria Serrat-Orús, Maria Teresa Sans-Mateu and Cristina Gutiérrez-Fornes. Epidemiology and prevention of nosocomial infections M. Montserrat Olona-Cabases.
ICU Nursing Department Xavier Teixidó,..
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