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All Studies   Meta Analysis    Recent:   
0 0.5 1 1.5 2+ Mortality 73% Improvement Relative Risk HCQ for COVID-19  Rathod et al.  EARLY TREATMENT Is early treatment with HCQ + AZ beneficial for COVID-19? Retrospective 565 patients in India (March - June 2020) Lower mortality with HCQ + AZ (p=0.02) c19hcq.org Rathod et al., The J. the Association .., Jun 2023 Favors HCQ Favors control

Risk Factors associated with COVID-19 Patients in India: A Single Center Retrospective Cohort Study

Rathod et al., The Journal of the Association of Physicians of India, doi:10.5005/japi-11001-0263
Jun 2023  
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HCQ for COVID-19
1st treatment shown to reduce risk in March 2020
 
*, now known with p < 0.00000000001 from 422 studies, recognized in 42 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,000+ studies for 60+ treatments. c19hcq.org
Retrospective 565 COVID-19 patients in India, showing lower mortality with HCQ+AZ treatment. Most patients (66%) had mild disease at baseline.
risk of death, 73.0% lower, HR 0.27, p = 0.02, treatment 513, control 52, Cox proportional hazards.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Rathod et al., 1 Jun 2023, retrospective, India, peer-reviewed, 6 authors, study period 28 March, 2020 - 3 June, 2020, average treatment delay 5.0 days, dosage not specified, this trial uses multiple treatments in the treatment arm (combined with AZ) - results of individual treatments may vary.
This PaperHCQAll
Risk Factors associated with COVID-19 Patients in India: A Single Center Retrospective Cohort Study
Darshana Rathod, Ketan Kargirwar, Mayur Patel, Vivek Kumar, Kavita Shalia, Pratibha Singhal
doi:10.5005/japi-11001-0263
Background and objectives: The coronavirus disease 2019 (COVID-19) outbreak has caused a worldwide pandemic, resulting in >3.8 million deaths. Our aim is to identify the risk factors associated with in-hospital mortality using survival analysis considering the characteristics and outcomes of COVID-19 patients admitted to a dedicated tertiary-care hospital in Mumbai, India. Materials and methods: In a retrospective cohort study, 565 patients admitted from 28th March 2020 to 30th June 2020 were enrolled, and a follow-up was conducted till August 2020. To investigate the impact of COVID-19, survival analysis was performed using the Kaplan-Meier method. Potential risk factors associated with mortality were analyzed using logistic regression models for multivariate analysis and the Cox proportional hazards model for estimating hazard ratios (HRs). Results: From the 565 positive COVID-19 cases, 49 patients died (8.7%) and 516 (91.3%) were discharged. Overall, 119 patients (20%) required intensive care unit (ICU) admission, of which 70 (58%) patients survived. The Kaplan-Meier survival curve showed a significant association of COVID-19 infection with age (≥60; p = 0.008), hypertension (p = 0.03), dialysis (p = 0.0001), lung commodities (p = 0.01), breathlessness (p = 0.0001), severe disease upon high-resolution computed tomography (HRCT) analysis (p = 0.0001), ICU admission (p = 0.0001), and low lymphocyte count at admission (p = 0.0001). Additionally, patients receiving tocilizumab (p = 0.0001) and deprived of hydroxychloroquine (HCQ) + azithromycin (azee) (p = 0.0001) were estimated at a high risk of mortality. Interpretation and conclusion: Coronavirus disease 2019 (COVID-19) increased the risk of mortality in patients with increased age, comorbidities, and severe symptoms upon treatment with an immunosuppressant (tocilizumab). However, patients treated with HCQ + azee showed favorable results due to their antiviral effects in vitro.
Ethics Committee approval: Institutional Review Board approved the study with the IEC protocol number HNH/IEC/2021/ OCS/CCM/55. Informed consent: The requirement for written informed consent was waived by the IEC.
References
Banerjee, Raju, Gendered mobility: women migrants and work in urban India, Econ Polit Wkly
Choudhuri, Duggal, Ahuja, The efficacy and safety of hydroxychloroquine (HCQ) in treatment of COVID19 -a systematic review and meta-analysis, Indian J Med Microbiol
Costa, Rosário, Farias, Metabolic syndrome and COVID-19: an update on the associated comorbidities and proposed therapies, Diabetes Metab Syndr
Covid-19, Treatment Guidelines Panel. Coronavirus disease 2019(COVID-19) Treatment Guidelines, National Institutes of Health. Available
Guzik, Mohiddin, Dimarco, COVID-19 and the cardiovascular system: Implications for risk assessment, diagnosis, and treatment options, Cardiovasc Res
Har Tley, Perencevich, Public health interventions for COVID-19: emerging evidence and implications for an evolving public health crisis, JAMA
Heo, Park, Han, COVID-19 outcome prediction and monitoring solution for military hospitals in South Korea: development and evaluation of an application, J Med Internet Res
Koya, Ebrahim, Bhat, COVID-19 and comorbidities: audit of 2,000 COVID-19 deaths in india, J Epidemiol Glob Health
Kraemer, Yang, Gutierrez, The effect of human mobility and control measures on the COVID 19 epidemic in China, Science
Leung, Ejupi, Van Schooten, Association between sedentary behaviour and physical, cognitive, and psychosocial status among older adults in assisted living, BioMed Res Int
Matsushita, Ding, Kou, The relationship of COVID-19 severity with cardiovascular disease and its traditional risk factors: a systematic review and meta-analysis, Glob Heart
Mehra, Desai, Kuy, Cardiovascular disease, drug therapy, and mortality in COVID-19, N Engl J Med
Mishra, Burma, Das, COVID-19-hospitalized patients in Karnataka: sur vival and stay characteristics, Indian J Public Health
Mishra, Mulani, Corticosteroids for COVID-19: the search for an optimum duration of therapy, Lancet Respir Med
Nih, Antithrombotic Therapy in Patients with COVID -19. Updated December 17
Ravaghi, Alidoost, Mannion, Models and methods for determining the optimal number of beds in hospitals and regions: a systematic scoping review, BMC Health Serv Res
Salama, Han, Yau, Tocilizumab in patients hospitalized with COVID-19 pneumonia, N Engl J Med
Shang, Wang, Zhang, The relationship between diabetes mellitus and COVID-19 prognosis: a retrospective cohort study in Wuhan, China, Am J Med
Tapnikar, Patil, Nyse, Interpreting Kaplan MEIER'S survival curve in COVID-19 patients: a systematic review, Int J Community Med Public Health
Thiruvengadam, Lakshmi, Ramanujam, A study of factors affecting the length of hospital stay of COVID-19 patients by cox-proportional hazard model in a South Indian tertiary care hospital, J Prim Care Community Health
Tobaiqy, Qashqary, Al-Dahery, Therapeutic management of patients with COVID-19: a systematic review, Infect Prev Pract
Wei, Xiao, Wang, Sex differences in severity and mortality among patients with COVID-19: evidence from pooled literature analysis and insights from integrated bioinformatic analysis
Who, Physical inactivity a leading cause of disease and disability warns WHO
Williamson, Walker, Bhaskaran, Factors associated with COVID-19-related death using OpenSAFELY, Nature
Yan, Yang, Wang, Clinical characteristics and outcomes of patients with severe COVID 19 with diabetes, BMJ Open Diabetes Res Care
Zheng, Ma, Zhang, COVID-19 and the cardiovascular system, Nat Rev Cardiol
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