Impact of SARS-CoV-2 infection on patients with systemic lupus erythematosus in England prior to vaccination: a retrospective observational cohort study
Adrian Paul J Rabe, Wei Jie Loke, Rubana N Kalyani, Raj Tummala, Heide A Stirnadel-Farrant, John Were, Kevin L Winthrop
BMJ Open, doi:10.1136/bmjopen-2022-071072
Objectives Determine the prevaccination healthcare impact of COVID-19 in patients with systemic lupus erythematosus (SLE) in England. Design Retrospective cohort study of adult patients with SLE from 1 May to 31 October 2020. Setting Clinical Practice Research Datalink (CPRD) Aurum and Hospital Episode Statistics (HES) databases from general practitioners across England combining primary care and other health-related data. Participants Overall, 6145 adults with confirmed SLE diagnosis ≥1 year prior to 1 May 2020 were included. Most patients were women (91.0%), white (67.1%), and diagnosed with SLE at age <50 (70.8%). Patients were excluded if they had a COVID-19 diagnosis before 1 May 2020. Primary and secondary outcome measures Demographics and clinical characteristics were compared. COVID-19 severity was determined by patient care required and procedure/diagnosis codes. COVID-19 cumulative incidence, hospitalisation rates, lengths of stay and mortality rates were determined and stratified by SLE and COVID-19 severity. Results Of 6145 patients, 3927 had mild, 1288 moderate and 930 severe SLE at baseline. The majority of patients with moderate to severe SLE were on oral corticosteroids and antimalarial treatments. Overall, 54/6145 (0.88%) patients with SLE acquired and were diagnosed with COVID-19, with 45 classified as mild, 6 moderate and 3 severe COVID-19. Cumulative incidence was higher in patients with severe SLE (1.4%) compared with patients classified as mild (0.8%) or moderate (0.8%). Ten COVID-19-specific hospital admissions occurred (n=6 moderate; n=4 severe). Regardless of COVID-19 status, hospital admission rates and length of stay increased with SLE severity. Of 54 patients with SLE diagnosed with COVID-19, 1 (1.9%) COVID-19-related death was recorded in a patient with both severe SLE and severe COVID-19. Conclusions SLE severity did not appear to impact COVID-19 outcomes in this study. The COVID-19 pandemic is evolving and follow-up studies are needed to understand the relationship between COVID-19 and SLE. ⇒ This study provided unique insight into the outcomes of COVID-19 for patients with systemic lupus erythematosus (SLE) before the availability of COVID-19 vaccines. ⇒ Due to the nature of a database study, there were limitations in the data captured in the system. ⇒ The number of diagnosed COVID-19 cases was low in patients with SLE. ⇒ The information about secondary care prescriptions in this population was limited.
Ethics approval This study used data that existed in an anonymised, structured format that contained no personal patient information. The study protocol was reviewed and approved by CPRD's Independent Scientific Advisory Committee (application number 21_000327) on 9 March 2021. Linkage of datasets was performed using anonymised and pseudonymised patient identification codes and was undertaken by NHS Digital, following study protocol approval. The CPRD obtains research ethics approval annually for receiving and supplying patient data for public health research from the UK's Health Research Authority Research Ethics Committee; no additional ethics approval is required for observational studies in public health research using CPRD Aurum data. Provenance and peer review Not commissioned; externally peer reviewed. Data availability statement Data are available upon reasonable request. Data underlying the findings described in this article may be obtained in accordance with AstraZeneca's data sharing policy described at https://astrazenecagrouptrials. pharmacm.com/ST/Submission/Disclosure Supplemental material This content has been supplied by the author(s). It has not been vetted by BMJ Publishing Group Limited (BMJ) and may not have been peer-reviewed. Any opinions or recommendations discussed are solely those of the author(s) and are not endorsed by BMJ. BMJ disclaims all liability and responsibility arising from any reliance placed on the content. Where the content includes any..
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'abstract': '<jats:sec><jats:title>Objectives</jats:title><jats:p>Determine the prevaccination healthcare '
'impact of COVID-19 in patients with systemic lupus erythematosus (SLE) in '
'England.</jats:p></jats:sec><jats:sec><jats:title>Design</jats:title><jats:p>Retrospective '
'cohort study of adult patients with SLE from 1 May to 31 October '
'2020.</jats:p></jats:sec><jats:sec><jats:title>Setting</jats:title><jats:p>Clinical Practice '
'Research Datalink (CPRD) Aurum and Hospital Episode Statistics (HES) databases from general '
'practitioners across England combining primary care and other health-related '
'data.</jats:p></jats:sec><jats:sec><jats:title>Participants</jats:title><jats:p>Overall, 6145 '
'adults with confirmed SLE diagnosis ≥1\u2009year prior to 1 May 2020 were included. Most '
'patients were women (91.0%), white (67.1%), and diagnosed with SLE at age <50 (70.8%). '
'Patients were excluded if they had a COVID-19 diagnosis before 1 May '
'2020.</jats:p></jats:sec><jats:sec><jats:title>Primary and secondary outcome '
'measures</jats:title><jats:p>Demographics and clinical characteristics were compared. '
'COVID-19 severity was determined by patient care required and procedure/diagnosis codes. '
'COVID-19 cumulative incidence, hospitalisation rates, lengths of stay and mortality rates '
'were determined and stratified by SLE and COVID-19 '
'severity.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Of 6145 '
'patients, 3927 had mild, 1288 moderate and 930 severe SLE at baseline. The majority of '
'patients with moderate to severe SLE were on oral corticosteroids and antimalarial '
'treatments. Overall, 54/6145 (0.88%) patients with SLE acquired and were diagnosed with '
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'evolving and follow-up studies are needed to understand the relationship between COVID-19 and '
'SLE.</jats:p></jats:sec>',
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