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All Studies   Meta Analysis    Recent:   

Early versus late acute kidney injury among patients with COVID-19—a multicenter study from Wuhan, China

Peng et al., Nephrology Dialysis Transplantation, doi:10.1093/ndt/gfaa288
Dec 2020  
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Progression 11% Improvement Relative Risk HCQ for COVID-19  Peng et al.  LATE TREATMENT Is late treatment with HCQ beneficial for COVID-19? Retrospective 4,020 patients in China No significant difference in progression c19hcq.org Peng et al., Nephrology Dialysis Trans.., Dec 2020 FavorsHCQ Favorscontrol 0 0.5 1 1.5 2+
HCQ for COVID-19
1st treatment shown to reduce risk in March 2020
 
*, now with p < 0.00000000001 from 411 studies, recognized in 46 countries.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,300+ studies for 75 treatments. c19hcq.org
Retrospective 4020 hospitalized patients in China showing non-statistically significant lower risk of acute kidney injury with HCQ.
risk of progression, 10.8% lower, RR 0.89, p = 0.63, treatment 29 of 453 (6.4%), control 256 of 3,567 (7.2%), NNT 129, CQ/HCQ risk of AKI.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Peng et al., 4 Dec 2020, retrospective, China, peer-reviewed, 21 authors.
This PaperHCQAll
Early versus late acute kidney injury among patients with COVID-19—a multicenter study from Wuhan, China
Suyuan Peng, Huai-Yu Wang, Xiaoyu Sun, Pengfei Li, Zhanghui Ye, Qing Li, Jinwei Wang, Xuanyu Shi, Liu Liu, Ying Yao, Rui Zeng, Fan He, Junhua Li, Shuwang Ge, Xianjun Ke, Zhibin Zhou, Erdan Dong, Haibo Wang, Gang Xu, Luxia Zhang, Ming-Hui Zhao
Nephrology Dialysis Transplantation, doi:10.1093/ndt/gfaa288
Background. Acute kidney injury (AKI) is an important complication of coronavirus disease 2019 , which could be caused by both systematic responses from multi-organ dysfunction and direct virus infection. While advanced evidence is needed regarding its clinical features and mechanisms. We aimed to describe two phenotypes of AKI as well as their risk factors and the association with mortality. Methods. Consecutive hospitalized patients with COVID-19 in tertiary hospitals in Wuhan, China from 1 January 2020 to 23 March 2020 were included. Patients with AKI were classified as AKI-early and AKI-late according to the sequence of organ dysfunction (kidney as the first dysfunctional organ or not). Demographic and clinical features were compared between two AKI groups. Their risk factors and the associations with inhospital mortality were analyzed. Results. A total of 4020 cases with laboratory-confirmed COVID-19 were included and 285 (7.09%) of them were identified as AKI. Compared with patients with AKI-early, patients with AKI-late had significantly higher levels of systemic inflammatory markers. Both AKIs were associated with an increased risk of in-hospital mortality, with similar fully adjusted hazard ratios of 2.46 [95% confidence interval (CI) 1.35-4.49] for AKIearly and 3.09 (95% CI 2.17-4.40) for AKI-late. Only hypertension was independently associated with the risk of AKI-early. While age, history of chronic kidney disease and the levels of inflammatory biomarkers were associated with the risk of AKIlate. Conclusions. AKI among patients with COVID-19 has two clinical phenotypes, which could be due to different mechanisms. Considering the increased risk for mortality for both phenotypes, monitoring for AKI should be emphasized during COVID-19.
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While advanced evidence is needed ' 'regarding its clinical features and mechanisms. We aimed to describe two phenotypes of AKI as ' 'well as their risk factors and the association with mortality.</jats:p>\n' ' </jats:sec>\n' ' <jats:sec>\n' ' <jats:title>Methods</jats:title>\n' ' <jats:p>Consecutive hospitalized patients with COVID-19 in tertiary ' 'hospitals in Wuhan, China from 1 January 2020 to 23 March 2020 were included. Patients with ' 'AKI were classified as AKI-early and AKI-late according to the sequence of organ dysfunction ' '(kidney as the first dysfunctional organ or not). Demographic and clinical features were ' 'compared between two AKI groups. Their risk factors and the associations with in-hospital ' 'mortality were analyzed.</jats:p>\n' ' </jats:sec>\n' ' <jats:sec>\n' ' <jats:title>Results</jats:title>\n' ' <jats:p>A total of 4020 cases with laboratory-confirmed COVID-19 were ' 'included and 285 (7.09%) of them were identified as AKI. Compared with patients with ' 'AKI-early, patients with AKI-late had significantly higher levels of systemic inflammatory ' 'markers. Both AKIs were associated with an increased risk of in-hospital mortality, with ' 'similar fully adjusted hazard ratios of 2.46 [95% confidence interval (CI) 1.35–4.49] for ' 'AKI-early and 3.09 (95% CI 2.17–4.40) for AKI-late. Only hypertension was independently ' 'associated with the risk of AKI-early. While age, history of chronic kidney disease and the ' 'levels of inflammatory biomarkers were associated with the risk of AKI-late.</jats:p>\n' ' </jats:sec>\n' ' <jats:sec>\n' ' <jats:title>Conclusions</jats:title>\n' ' <jats:p>AKI among patients with COVID-19 has two clinical phenotypes, which ' 'could be due to different mechanisms. 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Late treatment
is less effective
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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