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All Studies   Meta Analysis    Recent:   

Factors Associated with COVID-19 Breakthrough Infection Among Vaccinated Patients with Rheumatic Diseases: A Cohort Study

Patel et al., Seminars in Arthritis and Rheumatism, doi:10.1016/j.semarthrit.2022.152108
Oct 2022  
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Case, vs. other csDMARD 41% Improvement Relative Risk Case, vs. methotrexate 21% Case, vs. TNF inhibitor 55% HCQ for COVID-19  Patel et al.  Prophylaxis Is pre-exposure prophylaxis with HCQ beneficial for COVID-19? Retrospective study in the USA Fewer cases with HCQ (p=0.02) c19hcq.org Patel et al., Seminars in Arthritis an.., Oct 2022 FavorsHCQ Favorscontrol 0 0.5 1 1.5 2+
HCQ for COVID-19
1st treatment shown to reduce risk in March 2020
 
*, now with p < 0.00000000001 from 411 studies, recognized in 46 countries.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,500+ studies for 81 treatments. c19hcq.org
Retrospective 11,468 vaccinated rheumatic disease patients, showing lower risk of COVID-19 cases with HCQ/CQ (antimalarial) treatment compared with all other treatments, statistically significant for 6 treatments.
This study is excluded in meta analysis: authors only provide multiple results comparing with specific other treatments.
risk of case, 41.2% lower, HR 0.59, p = 0.02, adjusted per study, inverted to make HR<1 favor treatment, HCQ/CQ vs. other csDMARD, multivariable, Cox proportional hazards.
risk of case, 21.3% lower, HR 0.79, p = 0.34, adjusted per study, inverted to make HR<1 favor treatment, HCQ/CQ vs. methotrexate, multivariable, Cox proportional hazards.
risk of case, 54.8% lower, HR 0.45, p = 0.003, adjusted per study, inverted to make HR<1 favor treatment, HCQ/CQ vs. TNF inhibitor, multivariable, Cox proportional hazards.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Patel et al., 26 Oct 2022, retrospective, USA, peer-reviewed, mean age 60.0, 12 authors. Contact: zswallace@mgh.harvard.edu.
This PaperHCQAll
Factors associated with COVID-19 breakthrough infection among vaccinated patients with rheumatic diseases: A cohort study
Naomi J Patel, Xiaosong Wang, Xiaoqing Fu, Yumeko Kawano, Claire Cook, Kathleen M M Vanni, Grace Qian, Emily Banasiak, Emily Kowalski, Yuqing Zhang, Jeffrey A Sparks, Zachary S Wallace
Seminars in Arthritis and Rheumatism, doi:10.1016/j.semarthrit.2022.152108
This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
References
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'COVID-19 Global Rheumatology Alliance physician registry', 'author': 'Sparks', 'year': '2021', 'journal-title': 'Ann Rheum Dis'}, { 'key': '10.1016/j.semarthrit.2022.152108_bib0031', 'doi-asserted-by': 'crossref', 'first-page': 'e419', 'DOI': '10.1016/S2665-9913(21)00059-X', 'article-title': 'COVID-19 outcomes in patients with inflammatory rheumatic and ' 'musculoskeletal diseases treated with rituximab: a cohort study', 'volume': '3', 'author': 'Avouac', 'year': '2021', 'journal-title': 'Lancet Rheumatol'}, { 'key': '10.1016/j.semarthrit.2022.152108_bib0032', 'doi-asserted-by': 'crossref', 'article-title': 'Postvaccination antibody titres predict protection against COVID-19 in ' 'patients with autoimmune diseases: survival analysis in a prospective ' 'cohort', 'author': 'Ahmed', 'year': '2022', 'journal-title': 'Ann Rheum Dis', 'DOI': '10.1136/annrheumdis-2021-221922'}, { 'key': '10.1016/j.semarthrit.2022.152108_bib0033', 'doi-asserted-by': 'crossref', 'first-page': '191', 'DOI': 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