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0 0.5 1 1.5 2+ Case, vs. other csDMARD 41% Improvement Relative Risk Case, vs. methotrexate 21% Case, vs. TNF inhibitor 55% HCQ for COVID-19  Patel et al.  Prophylaxis Is pre-exposure prophylaxis with HCQ beneficial for COVID-19? Retrospective study in the USA Fewer cases with HCQ (p=0.02) c19hcq.org Patel et al., Seminars in Arthritis an.., Oct 2022 Favors HCQ Favors control

Factors Associated with COVID-19 Breakthrough Infection Among Vaccinated Patients with Rheumatic Diseases: A Cohort Study

Patel et al., Seminars in Arthritis and Rheumatism, doi:10.1016/j.semarthrit.2022.152108
Oct 2022  
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HCQ for COVID-19
1st treatment shown to reduce risk in March 2020
 
*, now known with p < 0.00000000001 from 422 studies, recognized in 42 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,000+ studies for 60+ treatments. c19hcq.org
Retrospective 11,468 vaccinated rheumatic disease patients, showing lower risk of COVID-19 cases with HCQ/CQ (antimalarial) treatment compared with all other treatments, statistically significant for 6 treatments.
This study is excluded in meta analysis: authors only provide multiple results comparing with specific other treatments.
risk of case, 41.2% lower, HR 0.59, p = 0.02, adjusted per study, inverted to make HR<1 favor treatment, HCQ/CQ vs. other csDMARD, multivariable, Cox proportional hazards.
risk of case, 21.3% lower, HR 0.79, p = 0.34, adjusted per study, inverted to make HR<1 favor treatment, HCQ/CQ vs. methotrexate, multivariable, Cox proportional hazards.
risk of case, 54.8% lower, HR 0.45, p = 0.003, adjusted per study, inverted to make HR<1 favor treatment, HCQ/CQ vs. TNF inhibitor, multivariable, Cox proportional hazards.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Patel et al., 26 Oct 2022, retrospective, USA, peer-reviewed, mean age 60.0, 12 authors. Contact: zswallace@mgh.harvard.edu.
This PaperHCQAll
Factors associated with COVID-19 breakthrough infection among vaccinated patients with rheumatic diseases: A cohort study
Naomi J Patel, Xiaosong Wang, Xiaoqing Fu, Yumeko Kawano, Claire Cook, Kathleen M M Vanni, Grace Qian, Emily Banasiak, Emily Kowalski, Yuqing Zhang, Jeffrey A Sparks, Zachary S Wallace
Seminars in Arthritis and Rheumatism, doi:10.1016/j.semarthrit.2022.152108
This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
References
Ahmed, Mehta, Paul, Postvaccination antibody titres predict protection against COVID-19 in patients with autoimmune diseases: survival analysis in a prospective cohort, Ann Rheum Dis
Apostolidis, Kakara, Painter, Cellular and humoral immune responses following SARS-CoV-2 mRNA vaccination in patients with multiple sclerosis on anti-CD20 therapy, Nat Med
Avouac, Drumez, Hachulla, COVID-19 outcomes in patients with inflammatory rheumatic and musculoskeletal diseases treated with rituximab: a cohort study, Lancet Rheumatol
Bajema, Dahl, Evener, Comparative Effectiveness and Antibody Responses to Moderna and Pfizer-BioNTech COVID-19 Vaccines among Hospitalized Veterans -Five Veterans Affairs Medical Centers, United States, February 1, MMWR Morb Mortal Wkly Rep
Boekel, Stalman, Wieske, Breakthrough SARS-CoV-2 infections with the delta (B.1.617.2) variant in vaccinated patients with immune-mediated inflammatory diseases using immunosuppressants: a substudy of two prospective cohort studies, Lancet Rheumatol
Brosh-Nissimov, Orenbuch-Harroch, Chowers, BNT162b2 vaccine breakthrough: clinical characteristics of 152 fully vaccinated hospitalized COVID-19 patients in Israel, Clin Microbiol Infect
Charlson, Pompei, Ales, Mackenzie, A new method of classifying prognostic comorbidity in longitudinal studies: Development and validation, J Chron Dis
Cook, Patel, Silva, Clinical characteristics and outcomes of COVID-19 breakthrough infections among vaccinated patients with systemic autoimmune rheumatic diseases, Ann Rheum Dis
Cook, Patel, Silva, Clinical characteristics and outcomes of COVID-19 breakthrough infections among vaccinated patients with systemic autoimmune rheumatic diseases, Ann Rheum Dis
Cordtz, Kristensen, Westermann, COVID-19 infection and hospitalisation risk according to vaccination status and DMARD treatment in patients with rheumatoid arthritis, Rheumatology
Deepak, Kim, Paley, Glucocorticoids and B Cell Depleting Agents Substantially Impair Immunogenicity of mRNA Vaccines to SARS-CoV-2
Dickerman, Gerlovin, Madenci, Comparative Effectiveness of BNT162b2 and mRNA-1273 Vaccines in U.S. Veterans, N Engl J Med
Fragoulis, Karamanakos, Arida, Clinical outcomes of breakthrough COVID-19 after booster vaccination in patients with systemic rheumatic diseases, RMD Open
Friedman, Curtis, Winthrop, Impact of disease-modifying antirheumatic drugs on vaccine immunogenicity in patients with inflammatory rheumatic and musculoskeletal diseases, Ann Rheum Dis
Furer, Eviatar, Zisman, Immunogenicity and safety of the BNT162b2 mRNA COVID-19 vaccine in adult patients with autoimmune inflammatory rheumatic diseases and in the general population: a multicentre study, Ann Rheum Dis
Fusco, Moran, Cane, Evaluation of COVID-19 vaccine breakthrough infections among immunocompromised patients fully vaccinated with BNT162b2, J Med Econ
Grainger, Kim, Conway, Yazdany, Robinson, COVID-19 in people with rheumatic diseases: risks, outcomes, treatment considerations, Nat Rev Rheumatol
Haberman, Herati, Simon, Methotrexate hampers immunogenicity to BNT162b2 mRNA COVID-19 vaccine in immune-mediated inflammatory disease, Ann Rheum Dis
Kim, Servi, Polinski, Validation of rheumatoid arthritis diagnoses in health care utilization data, Arthritis Res Ther
Lawson-Tovey, Hyrich, Gossec, SARS-CoV-2 infection after vaccination in patients with inflammatory rheumatic and musculoskeletal diseases, Ann Rheum Dis
Liew, Gianfrancesco, Harrison, SARS-CoV-2 Breakthrough Infections Among Vaccinated Individuals with Rheumatic Disease: Results From the COVID-19 Global Rheumatology Alliance Provider Registry, RMD Open
Mrak, Tobudic, Koblischke, SARS-CoV-2 vaccination in rituximab-treated patients: B cells promote humoral immune responses in the presence of T-cell-mediated immunity, Ann Rheum Dis
Nalichowski, Keogh, Chueh, Murphy, Calculating the Benefits of a Research Patient Data Repository, AMIA Annu Symp Proc
Paik, Sparks, Kim, Immunogenicity, breakthrough infection, and underlying disease flare after SARS-CoV-2 vaccination among individuals with systemic autoimmune rheumatic diseases, Curr Opin Pharmacol
Risk, Hayek, Schiopu, COVID-19 vaccine effectiveness against omicron (B.1.1.529) variant infection and hospitalisation in patients taking immunosuppressive medications: a retrospective cohort study, The Lancet Rheumatology
Serling-Boyd, Silva, Hsu, Coronavirus disease 2019 outcomes among patients with rheumatic diseases 6 months into the pandemic, Ann Rheum Dis
Silva, Boyd, Wallwork, Clinical characteristics and outcomes of patients with coronavirus disease 2019 (COVID-19) and rheumatic disease: a comparative cohort study from a US 'hot spot', Ann Rheum Dis
Simon, Tascilar, Schmidt, Humoral and Cellular Immune Responses to SARS-CoV-2 Infection and Vaccination in Autoimmune Disease Patients With B Cell Depletion, Arthritis Rheumatol
Sparks, Wallace, Seet, Associations of baseline use of biologic or targeted synthetic DMARDs with COVID-19 severity in rheumatoid arthritis: Results from the COVID-19 Global Rheumatology Alliance physician registry, Ann Rheum Dis
Sun, Zheng, Madhira, Association Between Immune Dysfunction and COVID-19 Breakthrough Infection After SARS-CoV-2 Vaccination in the US, JAMA Intern Med
Widdifield, Kwong, Chen, Vaccine effectiveness against SARS-CoV-2 infection and severe outcomes among individuals with immune-mediated inflammatory diseases tested between March 1 and Nov 22, 2021, in Ontario, Canada: a population-based analysis, Lancet Rheumatol
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