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0 0.5 1 1.5 2+ Mortality 33% Improvement Relative Risk ARDS 68% HCQ for COVID-19  Ouedraogo et al.  LATE TREATMENT Is late treatment with HCQ beneficial for COVID-19? Retrospective 456 patients in Burkina Faso Lower severe cases with HCQ (p=0.001) c19hcq.org Ouedraogo et al., Revue des Maladies R.., Feb 2021 Favors HCQ Favors control

Factors associated with the occurrence of acute respiratory distress and death in patients with COVID-19 in Burkina Faso

Ouedraogo et al., Revue des Maladies Respiratoires, doi:10.1016/j.rmr.2021.02.001
Feb 2021  
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HCQ for COVID-19
1st treatment shown to reduce risk in March 2020
 
*, now known with p < 0.00000000001 from 422 studies, recognized in 42 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,100+ studies for 60+ treatments. c19hcq.org
Retrospective 456 patients in Burkina Faso showing lower risk of ARDS (p=0.001) and mortality (p=0.38) with HCQ.
risk of death, 33.0% lower, HR 0.67, p = 0.38, treatment 397, control 59, multivariate.
risk of ARDS, 68.0% lower, OR 0.32, p = 0.001, treatment 397, control 59, multivariate, RR approximated with OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Ouedraogo et al., 5 Feb 2021, retrospective, Burkina Faso, peer-reviewed, 14 authors.
This PaperHCQAll
Facteurs associés à la survenue de la détresse respiratoire aiguë et au décès chez des patients atteints de COVID-19 au Burkina Faso
A R Ouédraogo, G Bougma, A Baguiya, A Sawadogo, P R Kaboré, C J Minougou, A Diendéré, S Maiga, C R Agbaholou, A Hema, A Sondo, G Ouédraogo, A Sanou, M Ouedraogo
Revue des Maladies Respiratoires, doi:10.1016/j.rmr.2021.02.001
MOTS CLÉS COVID 19 ; Détresse respiratoire aiguë ; Décès ; Burkina Faso Résumé Introduction. -L'apparition d'un syndrome de détresse respiratoire aiguë constitue une des formes graves de la COVID-19. Bien qu'il y ait eu plusieurs études sur les facteurs pronostiques de sa forme sévère, aucune étude de ce type n'a été menée au Burkina Faso. Méthodes. -Il s'agit d'une étude de cohorte rétrospective conduite du 09 mars au 09 juin 2020 à Ouagadougou, Burkina Faso et qui a concerné 456 patients atteints de COVID-19. Résultats. -Près d'un quart des patients (23,2 %) avaient présenté une détresse respiratoire aiguë et 44,3 % d'entre eux en sont décédés. Un âge supérieur à 65 ans (HR :2,7 ; IC95 % : 1,5-5,1) et avoir une HTA (HR :1,9 ; IC95 % : 1-3,5) étaient indépendamment associés au risque de mortalité. Cependant, après ajustement, seul l'âge supérieur à 65 ans (HR :2,3 ; IC95 % : 1,2-4,3) était un facteur de risque de décès. Le taux de survie des patients de plus de 65 ans était à 7 jours de 38,5 % et 30,3 % à 15 jours. Conclusion. -La détresse respiratoire aiguë conduisant au décès est essentiellement retrouvée chez des sujets d'âge avancé atteints de la COVID-19. Une surveillance étroite de ces patients à haut risque peut permettre de réduire la létalité.
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Late treatment
is less effective
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