Hydroxychloroquine and Mortality in SARS-Cov-2 Infection; The HOPE- Covid-19 Registry.

{ 'indexed': {'date-parts': [[2022, 5, 16]], 'date-time': '2022-05-16T07:11:10Z', 'timestamp': 1652685070928}, 'reference-count': 0, 'publisher': 'Bentham Science Publishers Ltd.', 'content-domain': {'domain': [], 'crossmark-restriction': False}, 'published-print': {'date-parts': [[2022, 5, 14]]}, 'abstract': '<jats:sec>\n' '<jats:title>Background:</jats:title>\n' '<jats:p>Hydroxychloroquine (HCQ) may be an effective, safe, and affordable treatment for ' 'Covid-19 that can be used in selected patients. However, more evidence on its association, ' 'when it is used in different stages of the disease, with clinical outcomes, is required. This ' 'observational study investigates the association between treatment with HCQ and mortality, in ' 'patients with Covid-19.</jats:p>\n' '</jats:sec>\n' '<jats:sec>\n' '<jats:title>Methods:</jats:title>\n' '<jats:p>The data from 6217 patients who died or were discharged from 24 Spanish hospitals, ' 'were analyzed. Propensity matching scores (PMS) were used.</jats:p>\n' '</jats:sec>\n' '<jats:sec>\n' '<jats:title>Results:</jats:title>\n' '<jats:p>5094 patients received HCQ. Death was recorded for 17.5% of those who had HCQ and ' '34.1% of those who did not have it. Mortality was lower for those who had HCQ, OR=0.41 (95% ' 'CI=0.34-0.48). The PMS analysis also showed that mortality was lower for those receiving ' 'HCQ, OR=0.47 (95%CI=0.36-0.62). PMS analysis for categories revealed an association between ' 'HCQ and lowered mortality for patients over 65 years of age, with a past medical history of ' 'hypertension, for those who were diagnosed during admission with sepsis related organ ' 'failure, or pneumonia, and for those with lymphocytopenia, raised troponin, LDH, ferritin and ' 'D-dimer. No increase in mortality associated with HCQ was observed in any category of any of ' 'the variables investigated.</jats:p>\n' '</jats:sec>\n' '<jats:sec>\n' '<jats:title>Conclusions:</jats:title>\n' '<jats:p>HCQ could be associated with lower mortality for older patients, those with more ' 'severe disease and raised inflammatory markers. Further RCTs, observational studies, and ' 'summaries of both types of evidence on this topic, are necessary to select the precise ' 'profile of patients that may benefit from HCQ.</jats:p>\n' '</jats:sec>', 'DOI': '10.2174/2211352520666220514112951', 'type': 'journal-article', 'created': {'date-parts': [[2022, 5, 16]], 'date-time': '2022-05-16T06:53:58Z', 'timestamp': 1652684038000}, 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'Hydroxychloroquine and Mortality in SARS-Cov-2 Infection; The HOPE- Covid-19 Registry.', 'prefix': '10.2174', 'volume': '20', 'author': [ { 'given': 'Iván J.', 'family': 'Núñez-Gil', 'sequence': 'first', 'affiliation': [ { 'name': 'Hospital Clínico San Carlos. Universidad Complutense de Madrid, ' 'Instituto de Investigación Sanitaria del Hospital Clínico San ' 'Carlos (IdISSC]. Madrid, Spain.'}]}, { 'given': 'Luis', 'family': 'Ayerbe', 'sequence': 'additional', 'affiliation': [ { 'name': 'Centre of Primary Care and Public Health. Queen Mary University ' 'of London. UK | Carnarvon Medical Centre. Southend on Sea. UK'}]}, { 'given': 'Cristina', 'family': 'Fernandez-Pérez', 'sequence': 'additional', 'affiliation': [ { 'name': 'Hospital Universitario de Santiago de Compostela, Spain and ' 'Fundación IMAS. Madrid. Spain.'}]}, { 'given': 'Vicente', 'family': 'Estrada', 'sequence': 'additional', 'affiliation': [ { 'name': 'Hospital Clínico San Carlos. Universidad Complutense de Madrid, ' 'Instituto de Investigación Sanitaria del Hospital Clínico San ' 'Carlos (IdISSC]. Madrid, Spain.'}]}, { 'given': 'Charbel Maroun', 'family': 'Eid', 'sequence': 'additional', 'affiliation': [ { 'name': 'Hospital Universitario La Paz, Instituto de Investigación ' 'Hospital Universitario La Paz (IdiPAZ], Madrid, Spain.'}]}, { 'given': 'Ramón', 'family': 'Arroyo-Espliguero', 'sequence': 'additional', 'affiliation': [{'name': 'Hospital Universitario Guadalajara, Guadalajara, Spain.'}]}, { 'given': 'Rodolfo', 'family': 'Romero', 'sequence': 'additional', 'affiliation': [ { 'name': 'Hospital Universitario Getafe, Madrid, Spain. Universidad ' 'Europea de Madrid. Spain.'}]}, { 'given': 'Víctor Manuel', 'family': 'Becerra-Muñoz', 'sequence': 'additional', 'affiliation': [ { 'name': 'Unidad de Gestión Clínica Área del Corazón, Instituto de ' 'Investigación Biomédica de Málaga'}]}, { 'given': 'Aitor', 'family': 'Uribarri', 'sequence': 'additional', 'affiliation': [ { 'name': 'Hospital Clínico Universitario de Valladolid, Valladolid, Spain. ' 'CIBER-CV.'}]}, { 'given': 'Gisela', 'family': 'Feltes', 'sequence': 'additional', 'affiliation': [{'name': 'Hospital Nuestra Señora de América, Madrid, Spain.'}]}, { 'given': 'Daniela', 'family': 'Trabattoni', 'sequence': 'additional', 'affiliation': [{'name': "The Second People\\'s Hospital of Shenzhen, Shenzhen, China"}]}, { 'given': 'María', 'family': 'Molina', 'sequence': 'additional', 'affiliation': [{'name': 'Hospital Severo Ochoa, Leganés, Spain.'}]}, { 'given': 'Marcos García', 'family': 'Aguado', 'sequence': 'additional', 'affiliation': [{'name': 'Hospital Puerta de Hierro, Madrid, Spain.'}]}, { 'given': 'Martino', 'family': 'Pepe', 'sequence': 'additional', 'affiliation': [ { 'name': 'Azienda ospedaliero-universitaria consorziale policlinico di ' 'Bari. Bari, Italy.'}]}, { 'given': 'Enrico', 'family': 'Cerrato', 'sequence': 'additional', 'affiliation': [{'name': 'San Luigi Gonzaga University Hospital, Rivoli, Turin. Italy.'}]}, { 'given': 'Jia', 'family': 'Huang', 'sequence': 'additional', 'affiliation': [{'name': "The Second People\\'s Hospital of Shenzhen, Shenzhen, China"}]}, { 'given': 'Thamar Capel', 'family': 'Astrua', 'sequence': 'additional', 'affiliation': [{'name': 'Hospital Virgen del Mar, Madrid, Spain.'}]}, { 'given': 'Emilio', 'family': 'Alfonso', 'sequence': 'additional', 'affiliation': [ { 'name': 'Instituto de Cardiología y Cirugía Cardiovascular; Havana, ' 'Cuba.'}]}, { 'given': 'Alex F.', 'family': 'Castro-Mejía', 'sequence': 'additional', 'affiliation': [ { 'name': 'Hospital General del norte de Guayaquil IESS Los Ceibos. ' 'Guayaquil, Ecuador.'}]}, { 'given': 'Sergio', 'family': 'Raposeiras-Roubin', 'sequence': 'additional', 'affiliation': [ { 'name': 'Hospital Universitario Álvaro Cunqueiro, Instituto de ' 'Investigación Sanitaria Galicia Sur. Vigo, Spain.'}]}, { 'given': 'Luis', 'family': 'Buzón', 'sequence': 'additional', 'affiliation': [{'name': 'Hospital Universitario de Burgos, Spain.'}]}, { 'given': 'Carolina Espejo', 'family': 'Paeres', 'sequence': 'additional', 'affiliation': [ { 'name': 'Hospital Universitario Príncipe de Asturias, Alcalá de Henares, ' 'Spain'}]}, { 'given': 'Alba', 'family': 'Mulet', 'sequence': 'additional', 'affiliation': [ { 'name': 'Hospital Clínico Universitario, Incliva, Universidad de ' 'Valencia, Valencia, Spain.'}]}, { 'given': 'Nisha', 'family': 'Lal-Trehan', 'sequence': 'additional', 'affiliation': [ { 'name': 'University Hospital Joan XXIII. University Rovira Virgili. ' 'IISPV. Tarragona. Spain.'}]}, { 'given': 'Elisa', 'family': 'Garcia-Vazquez', 'sequence': 'additional', 'affiliation': [ { 'name': 'Hospital Clínico Universitario Virgen de la Arrixaca, ' 'IMIB-Arrixaca, Universidad de Murcia, CIBERCV. Murcia, Spain.'}]}, { 'given': 'Oscar', 'family': 'Fabregat-Andres', 'sequence': 'additional', 'affiliation': [{'name': 'Hospital IMED, Valencia, Spain.'}]}, { 'given': 'Ibrahim', 'family': 'Akin', 'sequence': 'additional', 'affiliation': [{'name': 'University Mannheim, Mannheim, Germany.'}]}, { 'given': 'Fabrizio', 'family': 'D´Ascenzo', 'sequence': 'additional', 'affiliation': [{'name': 'Hospital San Giovanni Battista, Turin. Italy.'}]}, { 'given': 'Paula', 'family': 'Gomez-Rosado', 'sequence': 'additional', 'affiliation': [ { 'name': 'Hospital Universitario Infanta Sofia. San Sebastian de los ' 'Reyes.Madrid, Spain.'}]}, { 'given': 'Fabrizio', 'family': 'Ugo', 'sequence': 'additional', 'affiliation': [{'name': "Sant\\'Andrea Hospital, Vercelli. Italy."}]}, { 'given': 'Antonio', 'family': 'Fernández-Ortiz', 'sequence': 'additional', 'affiliation': [ { 'name': 'Hospital Clínico San Carlos. Universidad Complutense de Madrid, ' 'Instituto de Investigación Sanitaria del Hospital Clínico San ' 'Carlos (IdISSC]. Madrid, Spain. | Hospital Universitario de ' 'Santiago de Compostela, Spain and Fundación IMAS. Madrid. ' 'Spain.'}]}, { 'given': 'Carlos', 'family': 'Macaya', 'sequence': 'additional', 'affiliation': [ { 'name': 'Hospital Clínico San Carlos. Universidad Complutense de Madrid, ' 'Instituto de Investigación Sanitaria del Hospital Clínico San ' 'Carlos (IdISSC]. Madrid, Spain. | Hospital Universitario de ' 'Santiago de Compostela, Spain and Fundación IMAS. Madrid. ' 'Spain.'}]}], 'member': '965', 'container-title': 'Anti-Infective Agents', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://www.eurekaselect.com/article/download?doi=10.2174/2211352520666220514112951', 'content-type': 'application/pdf', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://www.eurekaselect.com/204783/article', 'content-type': 'text/html', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://www.eurekaselect.com/article/download?doi=10.2174/2211352520666220514112951', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2022, 5, 16]], 'date-time': '2022-05-16T06:55:48Z', 'timestamp': 1652684148000}, 'score': 1, 'resource': {'primary': {'URL': 'https://www.eurekaselect.com/204783/article'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2022, 5, 14]]}, 'references-count': 0, 'alternative-id': ['LiveAll1'], 'URL': 'http://dx.doi.org/10.2174/2211352520666220514112951', 'relation': {}, 'ISSN': ['2211-3525'], 'subject': ['Infectious Diseases', 'Pharmacology'], 'container-title-short': 'AIA', 'published': {'date-parts': [[2022, 5, 14]]}}