DOI record:
{
"DOI": "10.2174/2211352520666220514112951",
"ISSN": [
"2211-3525"
],
"URL": "http://dx.doi.org/10.2174/2211352520666220514112951",
"abstract": "<jats:sec>\n<jats:title>Background:</jats:title>\n<jats:p>Hydroxychloroquine (HCQ) may be an effective, safe, and affordable treatment for Covid-19 that can be used in selected patients. However, more evidence on its association, when it is used in different stages of the disease, with clinical outcomes, is required. This observational study investigates the association between treatment with HCQ and mortality, in patients with Covid-19.</jats:p>\n</jats:sec>\n<jats:sec>\n<jats:title>Methods:</jats:title>\n<jats:p>The data from 6217 patients who died or were discharged from 24 Spanish hospitals, were analyzed. Propensity matching scores (PMS) were used.</jats:p>\n</jats:sec>\n<jats:sec>\n<jats:title>Results:</jats:title>\n<jats:p>5094 patients received HCQ. Death was recorded for 17.5% of those who had HCQ and 34.1% of those who did not have it. Mortality was lower for those who had HCQ, OR=0.41 (95% CI=0.34-0.48). The PMS analysis also showed that mortality was lower for those receiving HCQ, OR=0.47 (95%CI=0.36-0.62). PMS analysis for categories revealed an association between HCQ and lowered mortality for patients over 65 years of age, with a past medical history of hypertension, for those who were diagnosed during admission with sepsis related organ failure, or pneumonia, and for those with lymphocytopenia, raised troponin, LDH, ferritin and D-dimer. No increase in mortality associated with HCQ was observed in any category of any of the variables investigated.</jats:p>\n</jats:sec>\n<jats:sec>\n<jats:title>Conclusions:</jats:title>\n<jats:p>HCQ could be associated with lower mortality for older patients, those with more severe disease and raised inflammatory markers. Further RCTs, observational studies, and summaries of both types of evidence on this topic, are necessary to select the precise profile of patients that may benefit from HCQ.</jats:p>\n</jats:sec>",
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"name": "Hospital Clínico San Carlos. Universidad Complutense de Madrid, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC]. Madrid, Spain."
}
],
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"name": "Centre of Primary Care and Public Health. Queen Mary University of London. UK | Carnarvon Medical Centre. Southend on Sea. UK"
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"name": "Hospital Clínico San Carlos. Universidad Complutense de Madrid, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC]. Madrid, Spain."
}
],
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"name": "Hospital Universitario Getafe, Madrid, Spain. Universidad Europea de Madrid. Spain."
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],
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"given": "Víctor Manuel",
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"name": "Hospital Nuestra Señora de América, Madrid, Spain."
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"affiliation": [
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"name": "The Second People\\'s Hospital of Shenzhen, Shenzhen, China"
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"name": "Hospital Severo Ochoa, Leganés, Spain."
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{
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"name": "Hospital Puerta de Hierro, Madrid, Spain."
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],
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"name": "Azienda ospedaliero-universitaria consorziale policlinico di Bari. Bari, Italy."
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],
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"name": "San Luigi Gonzaga University Hospital, Rivoli, Turin. Italy."
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"name": "The Second People\\'s Hospital of Shenzhen, Shenzhen, China"
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"name": "Instituto de Cardiología y Cirugía Cardiovascular; Havana, Cuba."
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],
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{
"affiliation": [
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"name": "Hospital General del norte de Guayaquil IESS Los Ceibos. Guayaquil, Ecuador."
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"given": "Alex F.",
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"affiliation": [
{
"name": "Hospital Universitario Álvaro Cunqueiro, Instituto de Investigación Sanitaria Galicia Sur. Vigo, Spain."
}
],
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"name": "Hospital Universitario de Burgos, Spain."
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],
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{
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"name": "Hospital Universitario Príncipe de Asturias, Alcalá de Henares, Spain"
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"family": "Paeres",
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"name": "Hospital Clínico Universitario, Incliva, Universidad de Valencia, Valencia, Spain."
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],
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"name": "University Hospital Joan XXIII. University Rovira Virgili. IISPV. Tarragona. Spain."
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{
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"name": "Hospital Clínico Universitario Virgen de la Arrixaca, IMIB-Arrixaca, Universidad de Murcia, CIBERCV. Murcia, Spain."
}
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"affiliation": [
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"name": "Hospital IMED, Valencia, Spain."
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"family": "Fabregat-Andres",
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{
"affiliation": [
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"name": "University Mannheim, Mannheim, Germany."
}
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"family": "Akin",
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"affiliation": [
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"name": "Hospital San Giovanni Battista, Turin. Italy."
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"family": "D´Ascenzo",
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"name": "Hospital Universitario Infanta Sofia. San Sebastian de los Reyes.Madrid, Spain."
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"name": "Sant\\'Andrea Hospital, Vercelli. Italy."
}
],
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{
"affiliation": [
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"name": "Hospital Clínico San Carlos. Universidad Complutense de Madrid, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC]. Madrid, Spain. | Hospital Universitario de Santiago de Compostela, Spain and Fundación IMAS. Madrid. Spain."
}
],
"family": "Fernández-Ortiz",
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"affiliation": [
{
"name": "Hospital Clínico San Carlos. Universidad Complutense de Madrid, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC]. Madrid, Spain. | Hospital Universitario de Santiago de Compostela, Spain and Fundación IMAS. Madrid. Spain."
}
],
"family": "Macaya",
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"subject": [
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"title": "Hydroxychloroquine and Mortality in SARS-Cov-2 Infection; The HOPE- Covid-19 Registry.",
"type": "journal-article",
"volume": "20"
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