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0 0.5 1 1.5 2+ Symp. case, severe 92% Improvement Relative Risk Symp. case, moderate/se.. 85% Symp. case, all 48% HCQ  Nasri et al.  Prophylaxis  RCT Is pre-exposure prophylaxis with HCQ beneficial for COVID-19? RCT 143 patients in Iran (August - November 2020) Fewer symptomatic cases with HCQ (p=0.028) Nasri et al., Advanced Biomedical Rese.., Jan 2023 Favors HCQ Favors control

Efficacy of hydroxychloroquine in pre-exposure severe acute respiratory syndrome coronavirus 2 prophylaxis among high-risk healthcare workers: A multicenter study

Nasri et al., Advanced Biomedical Research, doi:10.4103/abr.abr_104_21, IRCT20200414047076N1
Jan 2023  
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HCQ for COVID-19
1st treatment shown to reduce risk in March 2020
*, now known with p < 0.00000000001 from 421 studies, recognized in 42 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
3,800+ studies for 60+ treatments.
RCT 143 healthcare workers in Iran, showing lower cases with HCQ prophylaxis, statistically significant only for moderate/severe cases. Baseline details are not provided.
risk of symptomatic case, 92.2% lower, RR 0.08, p = 0.03, treatment 0 of 70 (0.0%), control 6 of 73 (8.2%), NNT 12, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), severe cases.
risk of symptomatic case, 85.1% lower, RR 0.15, p = 0.003, treatment 2 of 70 (2.9%), control 14 of 73 (19.2%), NNT 6.1, moderate or severe cases.
risk of symptomatic case, 47.9% lower, RR 0.52, p = 0.16, treatment 7 of 70 (10.0%), control 14 of 73 (19.2%), NNT 11, all cases.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Nasri et al., 27 Jan 2023, Randomized Controlled Trial, Iran, peer-reviewed, mean age 29.7, 11 authors, study period 11 August, 2020 - 11 November, 2020, trial IRCT20200414047076N1.
This PaperHCQAll
Efficacy of hydroxychloroquine in pre-exposure severe acute respiratory syndrome coronavirus 2 prophylaxis among high-risk healthcare workers: A multicenter study
Dr Afsane Vaezi, Elahe Nasri, Hamed Fakhim, Mehrdad Salahi, Safiyeh Ghafel, Samane Pourajam, Ali Darakhshandeh, Nazila Kassaian, Somayeh Sadeghi, Behrooz Ataei, Shaghayeghhaghjooy Javanmard
Advanced Biomedical Research, doi:10.4103/abr.abr_104_21
The novel coronavirus disease 2019 (COVID-19) is a highly contagious infection associated with significant mortality and morbidity among risk groups and a devastating local economic burden around the world. [1, 2] During the pandemic,
Ethical conduct of research Conflicts of interest There are no conflicts of interest.
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