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All Studies   Meta Analysis   Recent:  
0 0.5 1 1.5 2+ Symp. case, severe 92% Improvement Relative Risk Symp. case, moderate/.. 85% Symp. case, all 48% HCQ  Nasri et al.  Prophylaxis  RCT Is pre-exposure prophylaxis with HCQ beneficial for COVID-19? RCT 143 patients in Iran (August - November 2020) Fewer symptomatic cases with HCQ (p=0.028) c19hcq.org Nasri et al., Advanced Biomedical Rese.., Jan 2023 Favors HCQ Favors control

Efficacy of hydroxychloroquine in pre-exposure severe acute respiratory syndrome coronavirus 2 prophylaxis among high-risk healthcare workers: A multicenter study

Nasri et al., Advanced Biomedical Research, doi:10.4103/abr.abr_104_21, IRCT20200414047076N1
Jan 2023  
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RCT 143 healthcare workers in Iran, showing lower cases with HCQ prophylaxis, statistically significant only for moderate/severe cases. Baseline details are not provided.
risk of symptomatic case, 92.2% lower, RR 0.08, p = 0.03, treatment 0 of 70 (0.0%), control 6 of 73 (8.2%), NNT 12, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), severe cases.
risk of symptomatic case, 85.1% lower, RR 0.15, p = 0.003, treatment 2 of 70 (2.9%), control 14 of 73 (19.2%), NNT 6.1, moderate or severe cases.
risk of symptomatic case, 47.9% lower, RR 0.52, p = 0.16, treatment 7 of 70 (10.0%), control 14 of 73 (19.2%), NNT 11, all cases.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Nasri et al., 27 Jan 2023, Randomized Controlled Trial, Iran, peer-reviewed, mean age 29.7, 11 authors, study period 11 August, 2020 - 11 November, 2020, trial IRCT20200414047076N1.
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Efficacy of hydroxychloroquine in pre-exposure severe acute respiratory syndrome coronavirus 2 prophylaxis among high-risk healthcare workers: A multicenter study
Dr Afsane Vaezi, Elahe Nasri, Hamed Fakhim, Mehrdad Salahi, Safiyeh Ghafel, Samane Pourajam, Ali Darakhshandeh, Nazila Kassaian, Somayeh Sadeghi, Behrooz Ataei, Shaghayeghhaghjooy Javanmard
Advanced Biomedical Research, doi:10.4103/abr.abr_104_21
The novel coronavirus disease 2019 (COVID-19) is a highly contagious infection associated with significant mortality and morbidity among risk groups and a devastating local economic burden around the world. [1, 2] During the pandemic,
Ethical conduct of research Conflicts of interest There are no conflicts of interest.
References
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Chang, Park, Kim, Park, Risk factors for disease progression in COVID-19 patients, BMC Infect Dis
Chang, Sun, Repositioning chloroquine as ideal antiviral prophylactic against COVID-19-time is now, Drug Discov Today
Cheng, Group, A multicenter, randomized, open-label, controlled trial to evaluate the efficacy and tolerability of hydroxychloroquine and a retrospective study in adult patients with mild to moderate coronavirus disease 2019 (COVID-19), PLoS One
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Huang, Wang, Li, Ren, Zhao et al., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China, Lancet
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Liu, Cao, Xu, Wang, Zhang et al., Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro, Cell Discov
Marmor, Carr, Easterbrook, Farjo, Mieler et al., Recommendations on screening for chloroquine and hydroxychloroquine retinopathy: A report by the American Academy of Ophthalmology, Ophthalmology
Mohammadi, Pourzamani, Karimi, Mohammadi, Mohammadi et al., Artificial neural network and logistic regression modelling to characterize COVID-19 infected patients in local areas of Iran, Biomed J
Parhizgar, Tahghighi, Introducing new antimalarial analogues of chloroquine and amodiaquine: A narrative review, Iran J Med Sci
Pereira, Challenges and cares to promote rational use of chloroquine and hydroxychloroquine in the management of coronavirus disease 2019 (COVID-19) pandemic: A timely review, J Toxicol Environ Health B Crit Rev
Rajasingham, Bangdiwala, Nicol, Skipper, Pastick et al., Hydroxychloroquine as pre-exposure prophylaxis for COVID-19 in healthcare workers: A randomized trial, medRxiv
Rosenberg, Dufort, Udo, Wilberschied, Kumar et al., Association of treatment with hydroxychloroquine or azithromycin with in-hospital mortality in patients with COVID-19 in New York State, JAMA
Sahu, Amrithanand, Mathew, Aggarwal, Nayer et al., COVID-19 in health care workers -A systematic review and metaanalysis, Am J Emerg Med
Wang, Cao, Zhang, Yang, Liu et al., Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro, Cell Res
Winzeler, Malaria research in the post-genomic era, Nature
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