Abstract: Clinical Epidemiology and Global Health 11 (2021) 100751 Contents lists available at ScienceDirect Clinical Epidemiology and Global Health journal homepage: www.elsevier.com/locate/cegh Original article Clinical review of COVID-19 patients presenting to a quaternary care private hospital in South India: A retrospective study Prithvi Mohandas *, Sathya Periasamy, Manimaran Marappan, Arun Sampath, Vanaja Kate Garfin Sundaram, Vijit Koshy Cherian MIOT International Hospital, Chennai, Tamil Nadu, 600089, India A R T I C L E I N F O A B S T R A C T Keywords: COVID-19 Epidemiology Risk factors SARS-CoV-2 South India Background: Coronavirus disease 2019 (COVID-19) has been declared a global public-health crisis due to its impact on health, economy, and mental well-being. Here, we evaluated the clinical and epidemiological pa­ rameters associated with COVID-19 in South India. Methods: A retrospective, quaternary care hospital-based study that included COVID-19 positive patients admitted to MIOT International Hospital, Chennai between 8 April–7 August 2020. Cases were identified by reverse transcriptase-polymerase chain reaction. Epidemiological, demographic, clinical, and radiological find­ ings were recorded and analyzed. The primary endpoint was stable discharge from hospital/patient recovery or death. Associations between risk factors and comorbidities were analyzed using Chi-Square/Fisher’s exact test. Results: Of the 5264 cases reviewed, 3345 cases were included. The mean (standard deviation, SD) age of the patients was 47.58 (16.69) years with a median and range hospital stay of 5 (2–41) days. 69.20% of patients were male. The most frequent comorbidities were diabetes (37.10%) and hypertension (29.10%). Contact history was available for 58% of patients. The most common symptoms were cough (36.60%), fever (28.30%), and myalgia (15.40%). Abnormal chest radiography was reported in 16.9% of patients. Phase of admission, age ≥50 years, hypertension, diabetes, coronary artery disease, chronic kidney disease was significantly associated with mor­ tality (p < 0.05). There were 142 (4.2%) deaths in this study. Conclusion: In this single centre hospital-based study, late presentation and more severe form of COVID pneu­ monia lead to higher mortality although it had lower mortality rate for COVID-19 in comparison. Late phase of the pandemic showed better outcomes vs. the early group.