Abstract: Markedly Lower Rates of Coronavirus Infection and Fatality in Malaria-Endemic Regions – A Clue to Treatment? Abstract This comparative analysis of coronavirus infection and death among 2.4 billion persons around the world demonstrates a wide (two orders of magnitude or one hundred-fold) disparity in coronavirus fatality rates between well-developed and less-developed countries. The difference is backward or counterintuitive. The current data demonstrates the surprising fact that those in more affluent countries are about one hundred times more likely to become infected with coronavirus infection and die. This effect is most apparent when these countries are compared to countries with the highest rates of endemic malaria. It is known that the novel coronavirus, also known as COVID-19, originated in Wuhan China and is transmitted from one country to another by travelers from a coronavirus-infested area. It is also known that travelers to malaria-endemic countries are likely to be taking antimalarial prophylaxis. There is also evidence that antimalarials, notably hydroxychloroquine, may have some efficacy in the treatment of coronavirus. In light of these facts, the mortality data presented here is highly probative for the hypothesis that prophylactic antimalarial use by its incoming visitors markedly attenuates a country’s coronavirus fatality rate. Keywords coronavirus, COVID-19, mortality, antimalarial, decrease, Africa, death, disparity, protective, treatment, malaria, SARS-CoV-2, epidemiology, statistics, migration, pharmacology