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All Studies   Meta Analysis    Recent:   

Electrocardiographic safety of daily Hydroxychloroquine 400mg plus Azithromycin 250mg as an ambulatory treatment for COVID-19 patients in Cameroon

Mfeukeu-Kuate et al.
Jun 2020  
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HCQ for COVID-19
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No life-threatening modifications of the QT interval was observed in non-severe COVID-19 patients treated ambulatory with HCQ+AZ. 51 relatively young patients 39 +/- 11.
Mfeukeu-Kuate et al., 29 Jun 2020, preprint, 29 authors.
This PaperHCQAll
Electrocardiographic safety of daily Hydroxychloroquine 400mg plus Azithromycin 250mg as an ambulatory treatment for COVID-19 patients in Cameroon
Liliane Mfeukeu-Kuate, MD; William Ngatchou, Mazou Ngou Temgoua, MD Charles Kouanfack, PhD Daniel Lemogoum, Joel Noutakdie Tochie, MD Armel Zemsi, MD Lauriane Fomete, MD; Skinner Skinner Lekelem, MD; Sylvain Sylvain Zemsi, BSc Joelle Sobngwi, PhD Thierry Ntandzi, Christian Ngongang Ouankou, MD Yves Wasnyo, MD, MPH Antoinette Ntsama Assiga, Jan René Nkeck, Ahmadou Musa Jingi, MD Magellan Guewo, Eric Walter Pefura Yone, Charlotte Moussi Omgba, MD, MPH Paul Owono Etoundi, Jean Cyr Yombi, MD Alain Menanga, MD Samuel Kingue, Jacqueline Ze Minkande, MD; Jean Claude Mbanya, PhD Pierre Ongolo Zogo, Pierre Joseph Fouda, MD Eugène Sobngwi
doi:10.1101/2020.06.24.20139386
Objective : To determine the early electrocardiographic changes in a cohort of ambulatory cameroonian COVID-19 patients treated with hydroxychloroquine and Azithromycin. Design : Prospective study. Setting : Treatment centres of the city of Yaounde, Cameroon, from May 7th to 24th 2020. Participants : We enrolled 51 consecutive confirmed COVID-19 on RT-PCR who having mild forms of COVID-19 and treated by hydroxychloroquine 200mg twice daily during seven days plus Azithromycin 500 mg the first day and 250 mg the remaining 4 days as per national standard. Main outcomes measures : The primary end-point was the change in QTc interval between day 0 (D0), day 3 (D3) and day 7 (D7). Secondary endpoints were changes in all other cardiac electrical conductivity patterns and the occurrence of clinical arrhythmic events during the course of treatment. Results: The population (29 men and 22 women) was aged 39 ± 11 years (range 17 to 61 years). Mean Tisdale score was 3.35±0.48. No significant change from baseline (D0) of QTc was observed at D7 (429±27 ms at D0 versus 396±26 ms at D7; p=0.27). A reduction of heart rate was observed between the D0 and D7 (75±13 bpm versus 70±13 bpm, p = 0.02) with increased QRS duration between D0 and D7 (95±10 ms versus 102±17 ms, p = 0.004). No symptomatic arrhythmic events occurred during the treatment course. Conclusions: No life-threatening modifications of the QT interval was observed in nonsevere COVID-19 patients treated ambulatory with hydroxychloroquine and azithromycin. Studies are needed in critical-ill and older patients.
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